CAS Number103420-77-5
SynonymsN-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide; Devazepida; DEVAZEPIDE; Devazepidum; MK-329
Molecular FormulaC25H20N4O2
Molecular Weight408.45
Purity≥98 (HPLC)%
Density1.31g/cm3
Boiling Point758.6ºC at 760mmHg
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 103420-77-5 |
| Catalog No. | 2A-9010069 |
| Chinese Name | 地伐西匹 |
| Synonyms | N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide; Devazepida; DEVAZEPIDE; Devazepidum; MK-329 |
| Molecular Formula | C25H20N4O2 |
| Molecular Weight | 408.45 |
| Purity | ≥98 (HPLC) |
| Density | 1.31g/cm3 |
| Boiling Point | 758.6ºC at 760mmHg |
| Appearance | powder |
| Storage Condition | The warehouse is ventilated and dried at low tempe |
| Application | Devazepide (L-364,718) is a potent, competitive, selective, orally available, non-peptide cholecystokinin (CCK) receptor antagonist with IC50 values of 81 pM, 45 pM and 245 nM for rat pancreas, bovi |
| PubChem ID | 329798778 |
| MDL Number | MFCD00864500 |
| SMILES | CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c4ccccc4)c5ccccc15 |
| InChI | 1S/C25H20N4O2/c1-29-21-14-8-6-12-18(21)22(16-9-3-2-4-10-16)27-23(25(29)31)28-24(30)20-15-17-11-5-7-13-19(17)26-20/h2-15,23,26H,1H3,(H,28,30)/t23-/m1/s1 |
| InChI Key | NFHRQQKPEBFUJK-HSZRJFAPSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/10069_1_103420_77_5.pdf |
| Bioactivity | Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders[1]. Related Catalog Research Areas >> Endocrinology Research Areas >> Others Target IC50: 45 pM (Rat pancreatic CCK receptor), 81 pM (Bovine gallbladder CCK receptor), 245 nM (Guinea pig brain CCK receptor)[1] References [1]. Chang RS, et al. Biochemical and pharmacological characterization of an extremely potent and selective nonpeptide cholecystokinin antagonist. Proc Natl Acad Sci U S A. 1986 Jul;83(13):4923-6. Chemical & Physical Properties Density 1.31g/cm3 Boiling Point 758.6ºC at 760mmHg Molecular Formula C25H20N4O2 Molecular Weight 408.45200 Flash Point 412.6ºC Exact Mass 408.15900 PSA 77.56000 LogP 3.62930 Vapour Pressure 6.56E-23mmHg at 25°C Index of Refraction 1.696 InChIKey NFHRQQKPEBFUJK-HSZRJFAPSA-N SMILES CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 |
| Use of | Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders[1]. Properties Articles25 Name devazepide Synonym More Synonyms Devazepide Biological Activity Description Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders[1]. Related Catalog Research Areas >> Endocrinology Research Areas >> Others IC50: 45 pM (Rat pancreatic CCK receptor), 81 pM (Bovine gallbladder CCK receptor), 245 nM (Guinea pig brain CCK receptor)[1] References [1]. Chang RS, et al. Biochemical and pharmacological characterization of an extremely potent and selective nonpeptide cholecystokinin antagonist. Proc Natl Acad Sci U S A. 1986 Jul;83(13):4923-6. Chemical & Physical Properties Molecular Formula C25H20N4O2 Exact Mass 408.15900 PSA 77.56000 LogP 3.62930 Index of Refraction 1.696 InChIKey NFHRQQKPEBFUJK-HSZRJFAPSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Devazepide) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Devazepide) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Devazepide) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: I International Dangerous Regulations for sea transport: I International Dangerous Regulations for air transport: I 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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