CAS Number90038-01-0
Synonyms1H-Imidazole, 5-[(2,3-dimethylphenyl)methyl]-, hydrochloride (1:1); 5-[(2,3-dimethylphenyl)methyl]-1H-imidazole,hydrochloride; 4-(2,3-Dimethylbenzyl)-1H-imidazole hydrochloride (1:1)
Molecular FormulaC12H15ClN2
Molecular Weight222.71
Purity98.00%
Boiling Point386.5ºC at 760mmHg
Melting Point160ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 90038-01-0 |
| Catalog No. | 2A-9010064 |
| Chinese Name | 盐酸地托咪定 |
| Synonyms | 1H-Imidazole, 5-[(2,3-dimethylphenyl)methyl]-, hydrochloride (1:1); 5-[(2,3-dimethylphenyl)methyl]-1H-imidazole,hydrochloride; 4-(2,3-Dimethylbenzyl)-1H-imidazole hydrochloride (1:1) |
| Molecular Formula | C12H15ClN2 |
| Molecular Weight | 222.71 |
| Purity | 98.00 |
| Boiling Point | 386.5ºC at 760mmHg |
| Melting Point | 160ºC |
| Storage Condition | Room temperature, dry |
| Application | Detomidine is an α2-adrenergic agonist. |
| HTC | 2933290090 |
| SMILES | [Cl-].[nH]1cncc1Cc2c(c(ccc2)C)C.[H+] |
| InChI | 1S/C12H14N2.ClH/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12;/h3-5,7-8H,6H2,1-2H3,(H,13,14);1H |
| InChI Key | OIWRDXKNDCJZSM-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/10064_1_90038_01_0.pdf |
| Bioactivity | Detomidine hydrochloride produce dose-dependent sedative and analgesic effects, is a nonnarcotic, synthetic α2-adrenergic agonistTarget: α2-adrenergic agonistDetomidine is an imidazole derivative and α2-adrenergic agonist, used as a large animal sedative, primarily used in horses. It is usually available as the salt detomidine hydrochloride. It is a prescription medication available to veterinarians sold under the trade name Dormosedan. Currently, detomidine is only licenced for use in horses.Detomidine is a sedative with analgesic properties. α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease References [1]. Virtanen R, et al. Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic. J Vet Pharmacol Ther. 1985 Mar;8(1):30-7. Chemical & Physical Properties Boiling Point 386.5ºC at 760mmHg Melting Point 160ºC Molecular Formula C12H15ClN2 Molecular Weight 222.714 Flash Point 200.6ºC Exact Mass 222.092377 PSA 28.68000 LogP 3.41930 InChIKey OIWRDXKNDCJZSM-UHFFFAOYSA-N SMILES Cc1cccc(Cc2cnc[nH]2)c1C.Cl |
| Use of | Properties Articles25 Name Detomidine Hydrochloride Synonym More Synonyms Detomidine hydrochloride Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease References [1]. Virtanen R, et al. Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic. J Vet Pharmacol Ther. 1985 Mar;8(1):30-7. Chemical & Physical Properties Exact Mass 222.092377 PSA 28.68000 LogP 3.41930 InChIKey OIWRDXKNDCJZSM-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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