CAS Number638-94-8
SynonymsPrednacinolone; 16a,17a-Isopropylidenedioxyprednisolone; Desowen; Locapred; Desonide; Sterax; 16a-Hydroxy-D1-hydrocortisone-16a,17a-acetonide; 16a-Hydroxyprednisolone-16a,17-acetonide; Steroderm; 16a-Hydroxyprednisolone Acetonide; TRIDESILON; desonidum [INN_la]; MFCD00866151; 11b,21-Dihydroxy-16a,17-isopropylidenedioxy-1,4-pregnadiene-3,20-dione; d-2083; EINECS 211-351-6; 11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
Molecular FormulaC24H32O6
Molecular Weight416.51
Purity98%
Density1.3±0.1 g/cm3
Boiling Point580.1±50.0 °C at 760 mmHg
Melting Point274 - 275ºC
AppearanceSolid;White to Almost white powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 638-94-8 |
| Catalog No. | 2A-9010059 |
| Chinese Name | 地索奈德 |
| Synonyms | Prednacinolone; 16a,17a-Isopropylidenedioxyprednisolone; Desowen; Locapred; Desonide; Sterax; 16a-Hydroxy-D1-hydrocortisone-16a,17a-acetonide; 16a-Hydroxyprednisolone-16a,17-acetonide; Steroderm; 16a-Hydroxyprednisolone Acetonide; TRIDESILON; desonidum [INN_la]; MFCD00866151; 11b,21-Dihydroxy-16a,17-isopropylidenedioxy-1,4-pregnadiene-3,20-dione; d-2083; EINECS 211-351-6; 11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione |
| Molecular Formula | C24H32O6 |
| Molecular Weight | 416.51 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 580.1±50.0 °C at 760 mmHg |
| Melting Point | 274 - 275ºC |
| Appearance | Solid;White to Almost white powder to crystal |
| Storage Condition | Refrigerator |
| Application | Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on glucocorticoid receptors. |
| HTC | 2937210000 |
| MDL Number | MFCD00866151 |
| SMILES | CC1(C)OC2CC3C4CCC5=CC(=O)C=CC5(C)C4C(O)CC3(C)C2(C(=O)CO)O1 |
| InChI | InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15?,16-,17?,19+,20+,22?,23?,24+/m0/s1 |
| InChI Key | WBGKWQHBNHJJPZ-LECWWXJVSA-N |
| MSDS | msds/10059_1_638_94_8.pdf |
| Use of | Desonide is a nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses.Target: Glucocorticoid ReceptorDesonide is a low-potency topical corticosteroid that has been used for decades in the treatment of steroid-responsive dermatoses [1]. Desonide induced significant colorimetric improvement compared with placebo. A good to excellent response was achieved in 30% for desonide, and 6% for placebo. Decreased pigmentation in the desonide-treated axillae was associated with recovery of disruption at the basal membrane. Desonide showed depigmenting properties in women with axillary hyperpigmentation [2]. Given the favorable safety profile of all other desonide preparations and their utility as a low potency corticosteroid, desonide foam promises to be a useful addition to the armamentarium, when other desonide vehicles might be less acceptable [3]. Properties Name desonide Synonym More Synonyms Desonide Biological Activity Description Desonide is a nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses.Target: Glucocorticoid ReceptorDesonide is a low-potency topical corticosteroid that has been used for decades in the treatment of steroid-responsive dermatoses [1]. Desonide induced significant colorimetric improvement compared with placebo. A good to excellent response was achieved in 30% for desonide, and 6% for placebo. Decreased pigmentation in the desonide-treated axillae was associated with recovery of disruption at the basal membrane. Desonide showed depigmenting properties in women with axillary hyperpigmentation [2]. Given the favorable safety profile of all other desonide preparations and their utility as a low potency corticosteroid, desonide foam promises to be a useful addition to the armamentarium, when other desonide vehicles might be less acceptable [3]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology References [1]. Kahanek, N., C. Gelbard, and A. Hebert, Desonide: a review of formulations, efficacy and safety. Expert Opin Investig Drugs, 2008. 17(7): p. 1097-104. [2]. Castanedo-Cazares, J.P., et al., Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study. Clin Cosmet Investig Dermatol, 2013. 6: p. 29-36. [3]. Parish, D. and N. Scheinfeld, Desonide foam: a review. Drugs Today (Barc), 2008. 44(1): p. 55-62. Chemical & Physical Properties Molecular Formula C24H32O6 Exact Mass 416.219879 PSA 93.06000 Index of Refraction 1.598 InChIKey WBGKWQHBNHJJPZ-LECWWXJVSA-N Storage condition Refrigerator Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Prednisolone-16,17-acetonide, 16-alpha-hydroxy- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C24-H32-O6 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 20,522,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,111,1970 Safety Information Hazard Codes Xn RIDADR NONH for all modes of transport HS Code 2937210000 Synthetic Route Total: 1 Page 16α-Hydroxypred... CAS#:13951-70-7 CAS#:638-94-8 Literature: Journal of the American Chemical Society, , vol. 81, p. 4573 Precursor & DownStream Precursor 1 CAS#:13951-70-7 16α-Hydroxypred... DownStream 2 CAS#:51372-29-3 Budesonide CAS#:161115-59-9 Desisobutyryl-c... |
| Transport Info | Product Name: Disonide |
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