CAS Number2392-39-4
SynonymsTurbinaire; Dexamethasone 21-Phosphate Disodium Salt Hydrate; Oradexon; UNII-AI9376Y64P; Hexadrol; Solu-Decadron; Dalalone; Wymesone; DEXAMETHASONE DISODIUM PHOSPHATE; Dexamethasone Sodium Phosphate; Disodium (11β,16α)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl phosphate; Dexamethasone 21-phosphate disodium salt; MFCD00079105; EINECS 219-243-0; DEXAMETHASONE 21-(DISODIUM PHOSPHATE); Dezone; Soldesam; Dexamethasone phosphate disodium
Molecular FormulaC22H28FNa2O8P
Molecular Weight516.40
Purity≥98%
Density1.32g/cm3
Boiling Point669.6ºC at 760 mmHg
Melting Point233-235 °C
Appearancepowder
EINECS219-243-0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2392-39-4 |
| Catalog No. | 2A-9010072 |
| Chinese Name | 地塞米松磷酸钠 |
| Synonyms | Turbinaire; Dexamethasone 21-Phosphate Disodium Salt Hydrate; Oradexon; UNII-AI9376Y64P; Hexadrol; Solu-Decadron; Dalalone; Wymesone; DEXAMETHASONE DISODIUM PHOSPHATE; Dexamethasone Sodium Phosphate; Disodium (11β,16α)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl phosphate; Dexamethasone 21-phosphate disodium salt; MFCD00079105; EINECS 219-243-0; DEXAMETHASONE 21-(DISODIUM PHOSPHATE); Dezone; Soldesam; Dexamethasone phosphate disodium |
| Molecular Formula | C22H28FNa2O8P |
| Molecular Weight | 516.40 |
| Purity | ≥98 |
| Density | 1.32g/cm3 |
| Boiling Point | 669.6ºC at 760 mmHg |
| Melting Point | 233-235 °C |
| Appearance | powder |
| Water Solubility | H2O: 50 mg/mL, clear, faintly yellow |
| Storage Condition | Storage temperature 2-8° |
| EINECS | 219-243-0 |
| HTC | 2937290090 |
| PubChem ID | 24893369 |
| MDL Number | MFCD00079105 |
| SMILES | [Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O |
| InChI | 1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1 |
| InChI Key | PLCQGRYPOISRTQ-FCJDYXGNSA-L |
| Beilstein/REAXYS | 6473066 |
| NACRES Code | NA.25 |
| UNSPSC | 51422340 |
| Hazard Symbols | Transport |
| MSDS | msds/10072_1_2392_39_4.pdf |
| Bioactivity | Dexamethasone phosphate disodium is a glucocorticoid receptor agonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology Target Glucocorticoid receptor[1] In Vitro Dexamethasone regulates several transcription factors, including activator protein-1, nuclear factor-AT, and nuclear factor-kB, leading to the activation and repression of key genes involved in the inflammatory response[1]. Dexamethasone potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with EC50 of 2.2 nM. Dexamethasone (EC50=36 nM) induces transcription of the β2-receptor is found to correlate with glucocorticoid receptor (GR) DNA binding and occurred at 10-100 fold higher concentrations than the inhibition of GM-CSF release. Dexamethasone (IC50=0.5 nM) inhibits a 3×κB (NF-κB, IκBα, and I-κBβ), which is associated with inhibition of GM-CSF release[2]. In Vivo Treatment with Dexamethasone at a dose of 2×5 mg/kg efficiently inhibits lipopolysaccharide (LPS)-induced inflammation. In our experimental system, treatment with a single dose of Dexamethasone 10 mg/kg (i.p.) significantly decreases recruitment of granulocytes as well as spontaneous production of oxygen radicals compared with animals expose to LPS and injected with solvent alone (saline). The effects are statistically significant when administered both 1 h before and 1 h after inhalation of LPS. The number of granulocytes in BALF decreased to levels comparable to healthy animals (given an aerosol of water)[3]. Rats treated with Dexamethasone consume less food and weighed less than control rats. Treated rats also weigh less than pair-fed animals though their food intake is similar. Five days of Dexamethasone injection result in a significant increase in both the liver mass (+42%) and the liver to body weight ratio (+65%). The wet weight of gastrocnemius muscle decreases 20% after 5 days of treatment, but it remains unaffected relative to body weight (g/100 g body weight), indicating that muscle weight loss paralleled body weight loss[4]. Animal Admin Rats: Male Sprague-Dawley rats are used. Dexamethasone-treated rats are injected intraperitoneally once daily with Dexamethasone (1.5 mg/kg body weight) for 5 days and are allowed to feed ad libitum. Control rats receive no treatment and are fed ad libitum. In order to take into account the decrease in food intake induced by Dexamethasone treatment, a third group of pair-fed rats are used. These rats are provided with the same amount of food as Dexamethasone-injected rats and are treated with a daily isovolumic intraperitoneal injection of NaCl (0.9%) for 5 days. After the final injection of Dexamethasone or NaCl, the animals are fasted overnight prior to being killed by decapitation[4]. Mice: Female C57Bl/6JBom mice (age 10-12 weeks) are used in all experiments. Dexamethasone is administered as a single injection of 1 or 10 mg/kg. Dexamethasone is dissolved in saline and 400 μL are injected intraperitoneally, either 1 h before or 1 h after LPS exposure. In one experiment, N-acetylcysteine (NAC) (100 and 500 mg/kg) is injected successively every 4-5 h, starting 1 h before challenge (five injections in total). A control group of LPS-exposed animals are injected intraperitoneally with solvent alone (saline). Intratracheal administration is performed by instillation of 100 μL NAC (50, 100 or 500 mg/kg) or Dexamethasone (10 mg/kg) into the lungs of mice anaesthetized with 15 mg/kg Rapinovet (i.v.)[3]. References [1]. LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22. [2]. Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11. [3]. Rocksén D, et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122(2):249-56. [4]. Roussel D, et al. Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett. 2003 Apr 24;541(1-3):75-9. Chemical & Physical Properties Density 1.32g/cm3 Boiling Point 669.6ºC at 760 mmHg Melting Point 233-235 °C Molecular Formula C22H28FNa2O8P Molecular Weight 516.405 Flash Point 358.7ºC Exact Mass 516.130127 PSA 156.83000 LogP 2.88910 Vapour Pressure 2.81E-15mmHg at 25°C Index of Refraction 1.591 InChIKey PLCQGRYPOISRTQ-FCJDYXGNSA-L SMILES CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)COP(=O)([O-])[O-].[Na+].[Na+] Storage condition 2-8°C Water Solubility H2O: 50 mg/mL, clear, faintly yellow |
| Use of | Dexamethasone phosphate disodium is a glucocorticoid receptor agonist. Properties Articles54 Name dexamethasone sodium phosphate Synonym More Synonyms Dexamethasone 21-phosphate disodium salt Biological Activity Description Dexamethasone phosphate disodium is a glucocorticoid receptor agonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology Glucocorticoid receptor[1] References [1]. LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22. [2]. Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11. [3]. Rocksén D, et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122(2):249-56. [4]. Roussel D, et al. Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett. 2003 Apr 24;541(1-3):75-9. Chemical & Physical Properties Molecular Formula C22H28FNa2O8P Exact Mass 516.130127 PSA 156.83000 LogP 2.88910 Index of Refraction 1.591 InChIKey PLCQGRYPOISRTQ-FCJDYXGNSA-L |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Imported food hygiene supervision and inspection S. Export food hygiene supervision and inspection M. Imported commodity inspection N. Exported commodity inspection |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip. |
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