CAS Number477-30-5
SynonymsDemecolcine; (7S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one; demecolcinum; Colcemid; EINECS 207-514-6; demecolcina; N-Deacetyl-N-methylcolchicine; MFCD00075459
Molecular FormulaC21H25NO5
Molecular Weight371.43
Purity≥98 (HPLC)%
Density1.2±0.1 g/cm3
Boiling Point625.5±55.0 °C at 760 mmHg
Melting Point73-75ºC
Appearancecrystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 477-30-5 |
| Catalog No. | 2A-9010043 |
| Chinese Name | 秋水仙胺 |
| Synonyms | Demecolcine; (7S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one; demecolcinum; Colcemid; EINECS 207-514-6; demecolcina; N-Deacetyl-N-methylcolchicine; MFCD00075459 |
| Molecular Formula | C21H25NO5 |
| Molecular Weight | 371.43 |
| Purity | ≥98 (HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 625.5±55.0 °C at 760 mmHg |
| Melting Point | 73-75ºC |
| Appearance | crystalline powder |
| Storage Condition | Store in a sealed container in a ventilated and dr |
| Packaging | II |
| Application | Colchicine is a derivative of colchicine and is an effective mitosis inhibitor [1][2]. Colchicine binds to the protein tubulin and arrests cells in metaphase for karyotyping. Colchicine can induce apo |
| MDL Number | MFCD00075459 |
| SMILES | N(C1CCc2c(c(c(c(c2)OC)OC)OC)C3=CC=C(C(=O)C=C31)OC)C |
| InChI | 1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3 |
| InChI Key | NNJPGOLRFBJNIW-UHFFFAOYSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(a) |
| MSDS | msds/10043_1_477_30_5.pdf |
| Bioactivity | Colcemid (Demecolcine), a derivative of colchicine, is a potent mitotic inhibitor[1][2]. Colcemid binds to the protein tubulin and arrest cells in metaphase for karyotyping assays. Colcemid incuces cell apoptosis and can be used for cancer research[2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Research Areas >> Inflammation/Immunology Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin References [1]. T Tsuchida, et al. Colcemid-induced apoptosis of cultured human glioma: electron microscopic and confocal laser microscopic observation of cells sorted in different phases of cell cycle. Cytometry. 1998 Apr 1;31(4):295-9. [2]. Ashley M Rozario, et al. Ultra-Low Colcemid Doses Induce Microtubule Dysfunction as Revealed by Super-Resolution Microscopy. Bioexiv. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 625.5±55.0 °C at 760 mmHg Melting Point 73-75ºC Molecular Formula C21H25NO5 Molecular Weight 371.427 Flash Point 332.1±31.5 °C Exact Mass 371.173279 PSA 66.02000 LogP 1.52 Vapour Pressure 0.0±1.8 mmHg at 25°C Index of Refraction 1.582 InChIKey NNJPGOLRFBJNIW-HNNXBMFYSA-N SMILES CNC1CCc2cc(OC)c(OC)c(OC)c2-c2ccc(OC)c(=O)cc21 |
| Use of | Colcemid (Demecolcine), a derivative of colchicine, is a potent mitotic inhibitor[1][2]. Colcemid binds to the protein tubulin and arrest cells in metaphase for karyotyping assays. Colcemid incuces cell apoptosis and can be used for cancer research[2]. Properties Articles57 Name (-)-demecolcine Synonym More Synonyms (-)-Demecolcine Biological Activity Description Colcemid (Demecolcine), a derivative of colchicine, is a potent mitotic inhibitor[1][2]. Colcemid binds to the protein tubulin and arrest cells in metaphase for karyotyping assays. Colcemid incuces cell apoptosis and can be used for cancer research[2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Research Areas >> Inflammation/Immunology Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin References [1]. T Tsuchida, et al. Colcemid-induced apoptosis of cultured human glioma: electron microscopic and confocal laser microscopic observation of cells sorted in different phases of cell cycle. Cytometry. 1998 Apr 1;31(4):295-9. [2]. Ashley M Rozario, et al. Ultra-Low Colcemid Doses Induce Microtubule Dysfunction as Revealed by Super-Resolution Microscopy. Bioexiv. Chemical & Physical Properties Molecular Formula C21H25NO5 Exact Mass 371.173279 PSA 66.02000 Index of Refraction 1.582 InChIKey NNJPGOLRFBJNIW-HNNXBMFYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Demecolcine) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (Demecolcine) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Demecolcine) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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