CAS Number357-70-0
SynonymsMFCD00867189; 3,4-Dihydrogalanthamine; Galantamine; Nivalin; Lycoremine; Galantamine Hydrobromide; (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol; Galanthamine
Molecular FormulaC17H21O3N1
Molecular Weight287.36
Purity95%
Density1.3±0.1 g/cm3
Boiling Point439.3±45.0 °C at 760 mmHg
Melting Point119-121ºC
Appearanceoff-white solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 357-70-0 |
| Catalog No. | 2A-9010679 |
| Chinese Name | 加兰他敏 |
| Synonyms | MFCD00867189; 3,4-Dihydrogalanthamine; Galantamine; Nivalin; Lycoremine; Galantamine Hydrobromide; (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol; Galanthamine |
| Molecular Formula | C17H21O3N1 |
| Molecular Weight | 287.36 |
| Purity | 95 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 439.3±45.0 °C at 760 mmHg |
| Melting Point | 119-121ºC |
| Appearance | off-white solid |
| Storage Condition | -20°C Freezer |
| Application | Galanthamine is a potent inhibitor of acetylcholinesterase (AChE) with an IC50 of 500 nM. |
| HTC | 2942000000 |
| UN(IATA) | 3077 |
| MDL Number | MFCD00867189 |
| SMILES | COc1ccc2c3c1OC1CC(O)C=CC31CCN(C)C2 |
| InChI | InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1 |
| InChI Key | ASUTZQLVASHGKV-JDFRZJQESA-N |
| MSDS | msds/10679_1_357_70_0.pdf |
| Use of | Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM. Properties Name galanthamine Synonym More Synonyms Galantamine Biological Activity Description Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM. Related Catalog Signaling Pathways >> Neuronal Signaling >> AChE Research Areas >> Neurological Disease Natural Products >> Others IC50: 0.5 μM (AChE)[1] References [1]. Melanie-Jayne R. Howes, et al. Acetylcholinesterase inhibitors of natural origin. International Journal of Research in Pharmaceutical and Biomedical Sciences 3(SI 1):67-86. [2]. Kuryatov A, et al. Roles of accessory subunits in alpha4beta2(*) nicotinic receptors. Mol Pharmacol. 2008 Jul;74(1):132-43. [3]. Kita Y, et al. Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice. Psychopharmacology (Berl). 2013 Feb;225(3):543-51. Chemical & Physical Properties Molecular Formula C17H21NO3 Exact Mass 287.152130 PSA 41.93000 Index of Refraction 1.636 InChIKey ASUTZQLVASHGKV-JDFRZJQESA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Galanthamine CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C17-H21-N-O3 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5177082 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 37,689,1994 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4550113 Safety Information Hazard Codes Xi HS Code 2942000000 Synthetic Route Galanthaminone Galantamine Literature: Shieh; Carlson Journal of Organic Chemistry, 1994 , vol. 59, # 18 p. 5463 - 5465 N-formyl-N-norg... 109606-37-3 Galantamine Literature: Node, Manabu; Kodama, Sumiaki; Hamashima, Yoshio; Katoh, Takahiro; Nishide, Kiyoharu; Kajimoto, Tetsuya Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 12 p. 1662 - 1679 (-)-isogalantha... 313047-12-0 Galantamine Literature: Trost; Toste Journal of the American Chemical Society, 2000 , vol. 122, # 45 p. 11262 - 11263 Precursor & DownStream Precursor 10 CAS#:510-77-0 Galanthaminone CAS#:109606-37-3 N-formyl-N-norg... CAS#:313047-12-0 (-)-isogalanthamine CAS#:869369-22-2 (4aR,6S,8aR)-4a... DownStream 7 CAS#:60755-80-8 O-Desmethyl gal... CAS#:41303-74-6 N-Desmethyl Gal... CAS#:357-70-0 Galantamine CAS#:510-77-0 Galanthaminone |
| Transport Info | Product name: Galanthamine |
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