CAS Number3733-63-9
SynonymsHydroxydiethylphenamine; Decloxizini hydrochloride; 1-(Diphenylmethyl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine; 1-Benzhydryl-4-[2-(2-hydroxyethoxy)ethyl]piperazine; 2-[2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy]ethanol; Decloxizini; Decloxizine [INN]; 1-Benzhydryl-4-(2-(2-hydroxyethoxy)ethyl)piperazine; Decloxizina [INN-Spanish]; 2-{2-[4-(Diphenylmethyl)-1-piperazinyl]ethoxy}ethanol; 2-[2-(4-Benzhydryl-piperazino)-aethoxy]-aethanol; 2-[2-(4-benzhydryl-piperazino)-ethoxy]-ethanol; 2-(2-(4-Benzhydrylpiperazin-1-yl)ethoxy)ethanol; UCB 1402; 2-[2-(4-diphenylmethyl-piperazin-1-yl)-ethoxy]-ethanol; 4-(diphenylmethyl)-1-[2-(2-hydroxyethoxy)ethyl]piperazine; Decloxizine; 2-{2-[4-(Diphenylmethyl)piperazin-1-yl]ethoxy}ethanol; Decloxizinum [INN-Latin]; DecloxizineHydrochloride
Molecular FormulaC21H28N2O2
Molecular Weight340.46
Purity98%
Density1.1±0.1 g/cm3
Boiling Point472.4±40.0 °C at 760 mmHg
AppearanceWhite or similar to white powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 3733-63-9 |
| Catalog No. | 2A-9010023 |
| Chinese Name | 去氯羟嗪 |
| Synonyms | Hydroxydiethylphenamine; Decloxizini hydrochloride; 1-(Diphenylmethyl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine; 1-Benzhydryl-4-[2-(2-hydroxyethoxy)ethyl]piperazine; 2-[2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy]ethanol; Decloxizini; Decloxizine [INN]; 1-Benzhydryl-4-(2-(2-hydroxyethoxy)ethyl)piperazine; Decloxizina [INN-Spanish]; 2-{2-[4-(Diphenylmethyl)-1-piperazinyl]ethoxy}ethanol; 2-[2-(4-Benzhydryl-piperazino)-aethoxy]-aethanol; 2-[2-(4-benzhydryl-piperazino)-ethoxy]-ethanol; 2-(2-(4-Benzhydrylpiperazin-1-yl)ethoxy)ethanol; UCB 1402; 2-[2-(4-diphenylmethyl-piperazin-1-yl)-ethoxy]-ethanol; 4-(diphenylmethyl)-1-[2-(2-hydroxyethoxy)ethyl]piperazine; Decloxizine; 2-{2-[4-(Diphenylmethyl)piperazin-1-yl]ethoxy}ethanol; Decloxizinum [INN-Latin]; DecloxizineHydrochloride |
| Molecular Formula | C21H28N2O2 |
| Molecular Weight | 340.46 |
| Purity | 98 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 472.4±40.0 °C at 760 mmHg |
| Appearance | White or similar to white powder |
| Storage Condition | Ventilated, low-temperature drying, stored separat |
| Application | Decloxizine (UCB-1402; NSC289116) is a histamine receptor H1 antagonist. |
| HTC | 2933599090 |
| MDL Number | MFCD00869150 |
| SMILES | OCCOCCN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1 |
| InChI | 1S/C21H28N2O2/c24-16-18-25-17-15-22-11-13-23(14-12-22)21(19-7-3-1-4-8-19)20-9-5-2-6-10-20/h1-10,21,24H,11-18H2 |
| InChI Key | OXBBIHZWNDPBMQ-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/10023_1_3733_63_9.pdf |
| Use of | Decloxizine(UCB-1402; NSC289116) is a histamine 1 receptor antagonist. Properties Name 2-[2-(4-benzhydrylpiperazin-1-yl)ethoxy]ethanol Synonym More Synonyms Decloxizine Biological Activity Description Decloxizine(UCB-1402; NSC289116) is a histamine 1 receptor antagonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Chemical & Physical Properties Molecular Formula C21H28N2O2 Exact Mass 340.215088 PSA 35.94000 Index of Refraction 1.576 InChIKey OXBBIHZWNDPBMQ-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Ethanol, 2-(2-(4-(diphenylmethyl)-1-piperazinyl)ethoxy)- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C21-H28-N2-O2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T6N DNTJ AYR&R& D2O2Q HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 8-15 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 9,134,1968 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 8-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 9,134,1968 Safety Information HS Code 2933599090 Synthetic Route Total: 1 Page N-Benzhydrylpip... CAS#:841-77-0 2-(2-Chloroetho... CAS#:628-89-7 Decloxizine CAS#:3733-63-9 Literature: Takeda Chemical Industries, Ltd. Patent: US6248740 B1, 2001 ; N-Benzhydrylpip... CAS#:841-77-0 Decloxizine CAS#:3733-63-9 Literature: Takeda Chemical Industries, Ltd. Patent: EP1243271 A1, 2002 ; Precursor & DownStream Precursor 2 CAS#:841-77-0 N-Benzhydrylpip... CAS#:628-89-7 2-(2-Chloroetho... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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