CAS Number1131-64-2
Synonyms3,4-Dihydroisoquinoline-2(1H)-carboxiMidaMide; EINECS 214-470-1; 3,4-Dihydro-2(1H)-isochinolin-carboxamidin; 3,4-dihydro-1H-isoquinoline-2-carboximidic acid amide; 3,4-Dihydro-2(1H)-isoquinolinecarboximidamide; Debrisoquin; Debrisochin; 1,2,3,4-Tetrahydroisochinolin-N-carboxamidin; 3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXAMIDINE; Isocaramidine; 3,4-Dihydro-2(1H)-isoquinolinecarbimidamide; 3,4-dihydro-1H-isoquinoline-2-carboximidamide
Molecular FormulaC20H26N6 · H2SO4
Molecular Weight448.54
Purity98.00%
Density1.24g/cm3
Boiling Point309.8ºC at 760mmHg
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1131-64-2 |
| Catalog No. | 2A-9010019 |
| Chinese Name | 异喹胍 |
| Synonyms | 3,4-Dihydroisoquinoline-2(1H)-carboxiMidaMide; EINECS 214-470-1; 3,4-Dihydro-2(1H)-isochinolin-carboxamidin; 3,4-dihydro-1H-isoquinoline-2-carboximidic acid amide; 3,4-Dihydro-2(1H)-isoquinolinecarboximidamide; Debrisoquin; Debrisochin; 1,2,3,4-Tetrahydroisochinolin-N-carboxamidin; 3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXAMIDINE; Isocaramidine; 3,4-Dihydro-2(1H)-isoquinolinecarbimidamide; 3,4-dihydro-1H-isoquinoline-2-carboximidamide |
| Molecular Formula | C20H26N6 · H2SO4 |
| Molecular Weight | 448.54 |
| Purity | 98.00 |
| Density | 1.24g/cm3 |
| Boiling Point | 309.8ºC at 760mmHg |
| Appearance | solid |
| Application | Norisopropamidine is a TMPRSS2 inhibitor that inhibits the entry of severe acute respiratory syndrome coronavirus 2 into human lung cell lines in a TMPRSS2-dependent manner, with an IC50 of 22 μM. Nor |
| HTC | 2933499090 |
| MDL Number | MFCD00153791 |
| SMILES | OS(O)(=O)=O.NC(=N)N1CCc2ccccc2C1.NC(=N)N3CCc4ccccc4C3 |
| InChI | 1S/2C10H13N3.H2O4S/c2*11-10(12)13-6-5-8-3-1-2-4-9(8)7-13;1-5(2,3)4/h2*1-4H,5-7H2,(H3,11,12);(H2,1,2,3,4) |
| InChI Key | CAYGYVYWRIHZCQ-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/10019_1_1131_64_2.pdf |
| Use of | Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin can be used for antiviral research[1]. Properties Name debrisoquin Synonym More Synonyms Biological Activity Description Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin can be used for antiviral research[1]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV Human Endogenous Metabolite References [1]. Amanda L. Peiffer, et.al.TMPRSS2 Inhibitor Discovery Facilitated through an In Silico and Biochemical Screening Platform.ACS Medicinal Chemistry Letters 2023 14 (6), 860-866. Chemical & Physical Properties Molecular Formula C10H13N3 Exact Mass 175.11100 PSA 53.11000 LogP 1.67610 Index of Refraction 1.649 InChIKey JWPGJSVJDAJRLW-UHFFFAOYSA-N Safety Information HS Code 2933499090 Synthetic Route Total: 1 Page CAS#:25934-17-2 3,4-DIHYDROISOQ... CAS#:1131-64-2 Literature: Gruenewald, Sanja; Wahl, Bettina; Bittner, Florian; Hungeling, Helen; Kanzow, Stephanie; Kotthaus, Joscha; Schwering, Ulrike; Mendel, Ralf R.; Clement, Bernd Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 8173 - 8177 1,2,3,4-Tetrahy... CAS#:91-21-4 Aminoiminometha... CAS#:1184-90-3 3,4-DIHYDROISOQ... CAS#:1131-64-2 Literature: McNeilab, Inc. Patent: US4656291 A1, 1987 ; Precursor & DownStream Precursor 2 CAS#:91-21-4 1,2,3,4-Tetrahy... CAS#:1184-90-3 Aminoiminometha... DownStream 1 CAS#:59333-79-8 (±)-3-BENZYLO... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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