| Chemical & Physical Properties | |
|---|---|
| CAS Number | 201530-41-8 |
| Catalog No. | 2A-9010027 |
| Chinese Name | 地拉罗司 |
| Synonyms | ICL-670; Exjade; Deferasirox |
| Molecular Formula | C21H15N3O4 |
| Molecular Weight | 373.36 |
| Purity | ≥98 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 672.1±65.0 °C at 760 mmHg |
| Melting Point | 260-262ºC |
| Appearance | powder |
| Storage Condition | -20°C Freezer |
| Application | Deferasirox (ICL 670) is an orally active chelating agent used to treat iron excess. |
| HTC | 2933990090 |
| MDL Number | MFCD09951804 |
| SMILES | N2(N\C(=C4\C=CC=CC\4=O)\N\C\2=C3\C=CC=CC\3=O)c1ccc(cc1)C(=O)O |
| InChI | 1S/C21H15N3O4/c25-17-7-3-1-5-15(17)19-22-20(16-6-2-4-8-18(16)26)24(23-19)14-11-9-13(10-12-14)21(27)28/h1-12,22-23H,(H,27,28)/b19-15-,20-16+ |
| InChI Key | FMSOAWSKCWYLBB-VBGLAJCLSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/10027_1_201530_41_8.pdf |
| Use of | Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload. Properties Name deferasirox Synonym More Synonyms Deferasirox Biological Activity Description Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others In Vivo The tumor is significantly smaller in the SIO mice treated with deferasirox compared with control. Mice treated with DFX showed longer survival than the other groups. Deferasirox has a survival benefit for SIO leukemia murine model in terms of iron chelation and antileukemic therapy[3]. References [1]. Sobbe A, et al. Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox. J Gastroenterol Hepatol. 2015 Mar;30(3):638-45. [2]. Kim JL, et al. The oral iron chelator deferasirox induces apoptosis in myeloid leukemia cells by targetingcaspase. Acta Haematol. 2011;126(4):241-5. [3]. Lee DH, et al. Deferasirox shows in vitro and in vivo antileukemic effects on murine leukemic cell lines regardless of iron status. Exp Hematol. 2013 Jun;41(6):539-46. Chemical & Physical Properties Molecular Formula C21H15N3O4 Exact Mass 373.106262 PSA 107.95000 Index of Refraction 1.699 InChIKey BOFQWVMAQOTZIW-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2933990090 Synthetic Route 4,6-bis(2-((tri... 1311284-26-0 Ethyl 4-hydrazi... 14685-90-6 Deferasirox 201530-41-8 4-Hydrazinylben... 2-(2-Hydroxyphe... Deferasirox 201530-41-8 Disalicylimide 4-Hydrazinylben... Deferasirox 201530-41-8 Precursor & DownStream Precursor 8 CAS#:1311284-26-0 4,6-bis(2-((tri... CAS#:14685-90-6 Ethyl 4-hydrazi... CAS#:619-67-0 4-Hydrazinylben... CAS#:1218-69-5 2-(2-Hydroxyphe... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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