CAS Number119356-77-3
Synonyms(1S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenyl-1-propanamine; Priligy; Dapoxetina; (1S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine; Dapoxetine; (1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine; (+)-N,N-Dimethyl-a-(2-(1-naphthalenyloxy)ethyl)benzenemethanamine; (S)-N,N-Dimethyl-a-(2-(1-naphthalenyloxy)ethyl)benzenemethanamine; (1s)-n,n-dimethyl-3-(1-naphthyloxy)-1-phenylpropan-1-amine; MFCD00865355; (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine; Dapoxetinum
Molecular FormulaC21H23O1N1
Molecular Weight305.42
Purity99%
Density1.1±0.1 g/cm3
Boiling Point454.4±38.0 °C at 760 mmHg
AppearanceWhite to off-white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 119356-77-3 |
| Catalog No. | 2A-9010005 |
| Chinese Name | 达泊西汀 |
| Synonyms | (1S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenyl-1-propanamine; Priligy; Dapoxetina; (1S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine; Dapoxetine; (1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine; (+)-N,N-Dimethyl-a-(2-(1-naphthalenyloxy)ethyl)benzenemethanamine; (S)-N,N-Dimethyl-a-(2-(1-naphthalenyloxy)ethyl)benzenemethanamine; (1s)-n,n-dimethyl-3-(1-naphthyloxy)-1-phenylpropan-1-amine; MFCD00865355; (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine; Dapoxetinum |
| Molecular Formula | C21H23O1N1 |
| Molecular Weight | 305.42 |
| Purity | 99 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 454.4±38.0 °C at 760 mmHg |
| Appearance | White to off-white crystalline powder |
| Storage Condition | 2-8°C |
| Application | Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used in research on premature ejaculation [1]. |
| HTC | 2922199090 |
| MDL Number | MFCD00865355 |
| SMILES | CN(C)C(CCOc1cccc2ccccc12)c1ccccc1 |
| InChI | InChI=1S/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21;/h3-14,20H,15-16H2,1-2H3;1H/t20-;/m0./s1 |
| InChI Key | USRHYDPUVLEVMC-FQEVSTJZSA-N |
| MSDS | msds/10005_1_119356_77_3.pdf |
| Use of | Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE)[1]. Properties Name Dapoxetine Synonym More Synonyms Dapoxetine Biological Activity Description Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE)[1]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter In Vitro Dapoxetine binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine≫dopamine. Dapoxetine inhibits the uptake of [3H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [3H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [3H]dopamine by the dopamine reuptake transporter with IC50 values of 202 nM and 1720 nM, respectively.[1] References [1]. Muammer Kendirci, et al. Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation. Ther Clin Risk Manag. 2007 Jun;3(2):277-89. [2]. Rabab H Sayed, et al. Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins. Toxicol Appl Pharmacol. 2016 Nov 15;311:52-60. Chemical & Physical Properties Molecular Formula C21H23NO Exact Mass 305.177979 PSA 12.47000 Index of Refraction 1.607 InChIKey USRHYDPUVLEVMC-FQEVSTJZSA-N Safety Information HS Code 2922199090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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