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Cyclopentolate hydrochloride structure, CAS 5870-29-1

Cyclopentolate hydrochloride

CAS Number5870-29-1

Synonyms2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate,hydrochloride

Molecular FormulaC17H26ClNO3

Molecular Weight327.85

Purity98%

Density

Boiling Point409.7ºC at 760mmHg

Melting Point137-141°

Flash Point

Appearance

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Cat. No.: 2A-9009952 Purity: 98%
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Quality Control of [ 5870-29-1 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number5870-29-1
Catalog No.2A-9009952
Chinese Name盐酸环喷托酯
Synonyms2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate,hydrochloride
Molecular FormulaC17H26ClNO3
Molecular Weight327.85
Purity98
Boiling Point409.7ºC at 760mmHg
Melting Point137-141°
Water SolubilityVery soluble in water, freely soluble in ethanol (
Storage Condition−20°C
ApplicationCyclopentolate (DL-Cyclopentolate) hydrochloride is a commonly used antimuscarinic drug in ophthalmology. Cyclopentolate hydrochloride is an atropine-like muscarinic receptor antagonist with a pKB of
HTC2922509090
PubChem ID329749486
MDL NumberMFCD00079048
SMILESCl.CN(C)CCOC(=O)C(c1ccccc1)C2(O)CCCC2
InChI1S/C17H25NO3.ClH/c1-18(2)12-13-21-16(19)15(14-8-4-3-5-9-14)17(20)10-6-7-11-17;/h3-5,8-9,15,20H,6-7,10-13H2,1-2H3;1H
InChI KeyRHKZVMUBMXGOLL-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/9952_1_5870_29_1.pdf
Use ofCyclopentolate (DL-Cyclopentolate) hydrochloride is an anti-muscarinic agent commonly used in the ophthalmologic practice. Cyclopentolate hydrochloride is an Atropine-like muscarinic receptors antagonist with a pKB value of 7.8 (on the circular ciliary muscle)[1][2]. Properties Name Cyclopentolate Hydrochloride Synonym More Synonyms Cyclopentolate Hydrochloride Biological Activity Description Cyclopentolate (DL-Cyclopentolate) hydrochloride is an anti-muscarinic agent commonly used in the ophthalmologic practice. Cyclopentolate hydrochloride is an Atropine-like muscarinic receptors antagonist with a pKB value of 7.8 (on the circular ciliary muscle)[1][2]. Related Catalog Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease References [1]. Öner V, Bulut A, Öter K. The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults. Eye (Lond). 2016;30(7):925‐928. [2]. Ishikawa H, DeSantis L, Patil PN. Selectivity of muscarinic agonists including (±)-aceclidine and antimuscarinics on the human intraocular muscles. J Ocul Pharmacol Ther. 1998;14(4):363‐373. [3]. Öner V, Bulut A, Öter K. The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults. Eye (Lond). 2016;30(7):925‐928. Chemical & Physical Properties Exact Mass 327.16000 PSA 49.77000 LogP 2.98210 Water Solubility Very soluble in water, freely soluble in ethanol (96 per cent). It shows polymorphism (5.9). Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Cyclopentaneacetic acid, 1-hydroxy-alpha-phenyl-, 2-(dimethylamino)ethyl ester, hydrochloride CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : L5TJ AYR&VO2N1&1 AQ &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Human - child DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.64- 1960- Volume(issue)/page/year: 87,634,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - child DOSE/DURATION : 50 ug/kg/I TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Behavioral - toxic psychosis REFERENCE : AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 105,91,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,314,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,444,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,314,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,444,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,516,1995 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2737 No. of Facilities: 112 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 3472 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2737 No. of Facilities: 131 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 2009 (estimated) No. of Female Employees: 1464 (estimated) Safety Information Hazard Codes Xi RIDADR NONH for all modes of transport WGK Germany 2 RTECS GY2450000 HS Code 2922509090
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