CAS Number50-04-4
SynonymsMFCD00003609; 17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate; 21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione; 4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate; Cortisone, 21-acetate; EINECS 200-006-5; 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate; Cortisone Acetate; 4-Pregnene-3,11,20-trione, 17α,21-dihydroxy-, 21-acetate; Cortisone (acetate)
Molecular FormulaC23H30O6
Molecular Weight402.48
Purity98%
Density1.3±0.1 g/cm3
Boiling Point577.3±50.0 °C at 760 mmHg
Melting Point237-240 °C (lit.)
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 50-04-4 |
| Catalog No. | 2A-9009916 |
| Chinese Name | 醋酸可的松 |
| Synonyms | MFCD00003609; 17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate; 21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione; 4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate; Cortisone, 21-acetate; EINECS 200-006-5; 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate; Cortisone Acetate; 4-Pregnene-3,11,20-trione, 17α,21-dihydroxy-, 21-acetate; Cortisone (acetate) |
| Molecular Formula | C23H30O6 |
| Molecular Weight | 402.48 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 577.3±50.0 °C at 760 mmHg |
| Melting Point | 237-240 °C (lit.) |
| Appearance | solid |
| Storage Condition | Shield from light and store in a sealed container. |
| Packaging | 25g/foil bag |
| Application | Cortisone (17-hydroxy-11-dehydrocorticosterone) acetate is a hormone secreted by the adrenal glands in response to stress. |
| PubChem ID | 329749456 |
| MDL Number | MFCD00003609 |
| SMILES | [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])C(=O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O |
| InChI | 1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1 |
| InChI Key | ITRJWOMZKQRYTA-RFZYENFJSA-N |
| Beilstein/REAXYS | 2067543 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/9916_1_50_04_4.pdf |
| Bioactivity | Cortisone acetate (17-hydroxy-11-dehydrocorticosterone), a 21-carbon steroid hormone, is one of the main hormones released by the adrenal gland in response to stress.IC50 Value: Target: Glucocorticoid Receptorin vitro: Cortisone suppressed this apoptosis at a concentration range of 1-10,000 ng/ml (2.8-28,000 nM) dose-dependently. Suppression of cortisol-induced apoptosis by cortisonewas consistently observed in PBMCs derived from 16 healthy subjects. Examination for inhibitory activities of the steroids against [3H]dexamethasone binding to PBMCs suggested that cortisone can bind cellular GC-receptors (GC-Rs), but the affinity of cortisone to GCRs is 1/30 or less than that of cortisol [1]. Apoptosis was also readily induced in primary cultures of third trimester decidual cells when treated with cortisol, cortisone, or dexamethasone (all 100 nM for 24 h) [2]. in vivo: The effects of a single dose of cortisone acetate (5 or 10 mg/100 g body weight) on B cells were examined in young chickens. A dose-dependent increase in numbers of circulating B lymphocytes and a change in their Ig-class distribution were followed by parallel increase in splenic plasma cells and serum immunoglobulins. The higher dose of cortisone produced changes in Bmu and Bgamma cells, whereas the lower dose primarily affected Bmu cells [3]. Adult female CD-1 mice received daily injections of cortisone acetate (0--50 mg/kg subcutaneously) and/or amphotericin B (0--12.5 mg/kg intraperitoneally) in a checkerboard combination dosage pattern for 30 days. Dosages of amphotericin B and cortisone acetate that produced little or no mortality individually produced significant (P less than 0.005) mortality in combination [4].Toxicity: Oral use of cortisone has a number of potential systemic side-effects: hyperglycemia, insulin resistance, diabetes mellitus, osteoporosis, anxiety, depression, amenorrhoea, cataracts and glaucoma, among other problems. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Cancer References [1]. Hirano T, et al. Cortisone counteracts apoptosis-inducing effect of cortisol in human peripheral-blood mononuclear cells. Int Immunopharmacol. 2001 Nov;1(12):2109-15. [2]. Chan J, et al. Glucocorticoid-induced apoptosis in human decidua: a novel role for 11beta-hydroxysteroid dehydrogenase in late gestation. J Endocrinol. 2007 Oct;195(1):7-15. [3]. Rusu VM, et al. In vivo effects of cortisone on the B cell line in chickens. J Immunol. 1975 Nov;115(5):1370-4. [4]. Kisch AL, et al. Synergistic nephrotoxicity of amphotericin B and cortisone acetate in mice. J Infect Dis. 1978 Jun;137(6):789-94. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 577.3±50.0 °C at 760 mmHg Melting Point 237-240 °C(lit.) Molecular Formula C23H30O6 Molecular Weight 402.481 Flash Point 197.3±23.6 °C Exact Mass 402.204254 PSA 97.74000 LogP 2.53 Vapour Pressure 0.0±3.6 mmHg at 25°C Index of Refraction 1.566 InChIKey ITRJWOMZKQRYTA-RFZYENFJSA-N SMILES CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(=O)CC21C Stability Stable. Incompatible with strong oxidizing agents. |
| Use of | Properties Articles36 Name Cortisone acetate Synonym More Synonyms Cortisone acetate Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Cancer References [1]. Hirano T, et al. Cortisone counteracts apoptosis-inducing effect of cortisol in human peripheral-blood mononuclear cells. Int Immunopharmacol. 2001 Nov;1(12):2109-15. [2]. Chan J, et al. Glucocorticoid-induced apoptosis in human decidua: a novel role for 11beta-hydroxysteroid dehydrogenase in late gestation. J Endocrinol. 2007 Oct;195(1):7-15. [3]. Rusu VM, et al. In vivo effects of cortisone on the B cell line in chickens. J Immunol. 1975 Nov;115(5):1370-4. [4]. Kisch AL, et al. Synergistic nephrotoxicity of amphotericin B and cortisone acetate in mice. J Infect Dis. 1978 Jun;137(6):789-94. Chemical & Physical Properties Molecular Formula C23H30O6 Exact Mass 402.204254 PSA 97.74000 Index of Refraction 1.566 InChIKey ITRJWOMZKQRYTA-RFZYENFJSA-N Stability Stable. Incompatible with strong oxidizing agents. |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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