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Convallatoxin structure, CAS 508-75-8

Convallatoxin

CAS Number508-75-8

SynonymsCONVALLATOXIN; Convallatoxin

Molecular FormulaC29H42O10

Molecular Weight550.64

Purity90%

Density1.41 g/cm3

Boiling Point757.3ºC at 760 mmHg

Melting Point235-242ºC

Flash Point

Appearancepowder

EINECS208-086-3

MSDSChineseEnglish

Symbol6.1(b)

Signal WordWarning

Cat. No.: 2A-9009909 Purity: 90%
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Quality Control of [ 508-75-8 ] Purity: 90% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number508-75-8
Catalog No.2A-9009909
Chinese NameK-毒毛旋花子配质-3-L-鼠李糖甙
SynonymsCONVALLATOXIN; Convallatoxin
Molecular FormulaC29H42O10
Molecular Weight550.64
Purity90
Density1.41 g/cm3
Boiling Point757.3ºC at 760 mmHg
Melting Point235-242ºC
Appearancepowder
Storage Condition2-8℃, dry
PackagingIII
ApplicationConvallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin improves colitis through activation of PPARγ and inhibition of NF-κB. Convallatoxin is a P-glycoprotei
EINECS208-086-3
PubChem ID24893136
MDL NumberMFCD00069477
SMILESC[C@@H]1O[C@@H](O[C@H]2CC[C@]3(C=O)[C@H]4CC[C@]5(C)[C@H](CC[C@]5(O)[C@@H]4CC[C@]3(O)C2)C6=CC(=O)OC6)[C@H](O)[C@H](O)[C@H]1O
InChI1S/C29H42O10/c1-15-22(32)23(33)24(34)25(38-15)39-17-3-8-27(14-30)19-4-7-26(2)18(16-11-21(31)37-13-16)6-10-29(26,36)20(19)5-9-28(27,35)12-17/h11,14-15,17-20,22-25,32-36H,3-10,12-13H2,1-2H3/t15-,17-,18+,19-,20+,22-,23+,24+,25-,26+,27-,28-,29-/m0/s1
InChI KeyHULMNSIAKWANQO-JQKSAQOKSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard Symbols6.1(b)
MSDSmsds/9909_1_508_75_8.pdf
BioactivityConvallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties[1][2][3]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein In Vitro Convallatoxin induces HaCaT cell necroptosis[4]. In Vivo Convallatoxin exerts antipsoriatic activities in two mouse models of psoriasis[4]. References [1]. Li MY, et al. Convallatoxin protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB signaling through activation of PPARγ. Pharmacol Res. 2019 Sep;147:104355. [2]. Gozalpour E, et al. Convallatoxin: a new P-glycoprotein substrate. Eur J Pharmacol. 2014 Dec 5;744:18-27. [3]. Chao PK, et al. Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice. Sci Rep. 2019 Feb 20;9(1):2405. [4]. Jiang BW, et al. Convallatoxin induces HaCaT cell necroptosis and ameliorates skin lesions in psoriasis-like mouse models. Biomed Pharmacother. 2020 Jan;121:109615. Chemical & Physical Properties Density 1.41 g/cm3 Boiling Point 757.3ºC at 760 mmHg Melting Point 235-242ºC Molecular Formula C29H42O10 Molecular Weight 550.63800 Flash Point 247.1ºC Exact Mass 550.27800 PSA 162.98000 LogP 0.75000 Index of Refraction 1.622 InChIKey HULMNSIAKWANQO-JQKSAQOKSA-N SMILES CC1OC(OC2CCC3(C=O)C4CCC5(C)C(C6=CC(=O)OC6)CCC5(O)C4CCC3(O)C2)C(O)C(O)C1O
Use ofConvallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties[1][2][3]. Properties Articles29 Name convallatoxin Synonym More Synonyms CONVALLATOXIN Biological Activity Description Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties[1][2][3]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein In Vitro Convallatoxin induces HaCaT cell necroptosis[4]. In Vivo Convallatoxin exerts antipsoriatic activities in two mouse models of psoriasis[4]. References [1]. Li MY, et al. Convallatoxin protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB signaling through activation of PPARγ. Pharmacol Res. 2019 Sep;147:104355. [2]. Gozalpour E, et al. Convallatoxin: a new P-glycoprotein substrate. Eur J Pharmacol. 2014 Dec 5;744:18-27. [3]. Chao PK, et al. Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice. Sci Rep. 2019 Feb 20;9(1):2405. [4]. Jiang BW, et al. Convallatoxin induces HaCaT cell necroptosis and ameliorates skin lesions in psoriasis-like mouse models. Biomed Pharmacother. 2020 Jan;121:109615. Chemical & Physical Properties Molecular Formula C29H42O10 Exact Mass 550.27800 PSA 162.98000 LogP 0.75000 Index of Refraction 1.622 InChIKey HULMNSIAKWANQO-JQKSAQOKSA-N
Transport InfoProduct name: lily of the valley toxin
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