CAS Number77-36-1
Synonyms2-Chloro-5-(3-hydroxy-1-oxoisoindolin-3-yl)benzenesulfonamide; Higroton; (±)-Chlorthalidone; Chlorthalidone; 2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide; MFCD00036257; 2-Chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzenesulfonamide; chlortalidone; (±)-Hygroton; 2-Chloro-5-(1-hydroxy-3-oxoisoindolin-1-yl)benzenesulfonamide; EINECS 201-022-5
Molecular FormulaC14H11ClN2O4S
Molecular Weight338.766
Purity98%
Density1.6±0.1 g/cm3
Melting Point265-267ºC (dec.)
AppearanceWhite to light yellow - white crystalline powder odorless
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 77-36-1 |
| Catalog No. | 2A-9009763 |
| Chinese Name | 氯噻酮 |
| Synonyms | 2-Chloro-5-(3-hydroxy-1-oxoisoindolin-3-yl)benzenesulfonamide; Higroton; (±)-Chlorthalidone; Chlorthalidone; 2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide; MFCD00036257; 2-Chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzenesulfonamide; chlortalidone; (±)-Hygroton; 2-Chloro-5-(1-hydroxy-3-oxoisoindolin-1-yl)benzenesulfonamide; EINECS 201-022-5 |
| Molecular Formula | C14H11ClN2O4S |
| Molecular Weight | 338.766 |
| Purity | 98 |
| Density | 1.6±0.1 g/cm3 |
| Melting Point | 265-267ºC (dec.) |
| Appearance | White to light yellow - white crystalline powder odorless |
| Water Solubility | DMSO: soluble5mg/mL, clear (warmed) |
| Storage Condition | This product should be sealed and stored in a cool |
| Application | Chlorthalidone is a thiazide diuretic used to treat high blood pressure. |
| HTC | 2935009090 |
| SMILES | NS(=O)(=O)c1cc(C2(O)NC(=O)c3ccccc32)ccc1Cl |
| InChI | InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21) |
| InChI Key | JIVPVXMEBJLZRO-UHFFFAOYSA-N |
| MSDS | msds/9763_1_77_36_1.pdf |
| Bioactivity | Chlorthalidone is a thiazide-like diuretic used to treat hypertension. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease In Vivo Chlorthalidone is a thiazide-like diuretic. After oral intake, peak serum concentrations are achieved in 2-6 hours. The half-life of Chlorthalidone is approximately 42 (range 29-55) hours, reaching 45-60 hours after long-term dosing. However, interindividual variability in the half-life of Chlorthalidone is wide. Chlorthalidone is excreted unchanged by the kidneys. The natriuretic effect of Chlorthalidone is maximal at 18 hours and lasts more than 48 hours. Comparing different doses of Chlorthalidone, it has been observed that 25 mg daily is nearly as effective as higher doses, but with less risk of hypokalemia[1]. Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. The effectiveness of Chlorthalidone or magnesium hydroxide is examined in the prevention of recurrent calcium oxalate kidney calculi. In a double-blind random allocation design daily dosages of 25 or 50 mg. Chlorthalidone, 650 or 1,300 mg. magnesium hydroxide, or an identical placebo are administered. All groups showed significantly decreased calculous events compared to the pretreatment rates. During the trial 56.1 per cent fewer calculi than predicted developed in the placebo group (p less than 0.01), whereas the groups receiving low and high dosage magnesium hydroxide showed 73.9 and 62.3 per cent fewer calculi, respectively (p less than 0.001 and less than 0.01, respectively). Chlorthalidone treatment results in a 90.1 per cent decrease from predicted rates and both dosages yielded similar results. When the treatments are compared Chlorthalidone is significantly better than the placebo or magnesium hydroxide (p less than 0.01). The large decreases in calculous events seen when placebo or ineffective therapy is given underscore the positive treatment bias that occurs when historical controls are used and they demonstrate the need for proper experimental design[2]. References [1]. Barrios V, et al. Which thiazide to choose as add-on therapy for hypertension? Integr Blood Press Control. 2014 Jul 30;7:35-47. [2]. Ettinger B, et al. Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. J Urol. 1988 Apr;139(4):679-84. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Melting Point 265-267ºC (dec.) Molecular Formula C14H11ClN2O4S Molecular Weight 338.766 Exact Mass 338.012817 PSA 117.87000 LogP -0.74 Index of Refraction 1.694 InChIKey JIVPVXMEBJLZRO-UHFFFAOYSA-N SMILES NS(=O)(=O)c1cc(C2(O)NC(=O)c3ccccc32)ccc1Cl Storage condition 2-8°C Water Solubility DMSO: soluble5mg/mL, clear (warmed) |
| Use of | Chlorthalidone is a thiazide-like diuretic used to treat hypertension. Properties Articles41 Name chlorthalidone Synonym More Synonyms Chlorthalidone Biological Activity Description Chlorthalidone is a thiazide-like diuretic used to treat hypertension. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease References [1]. Barrios V, et al. Which thiazide to choose as add-on therapy for hypertension? Integr Blood Press Control. 2014 Jul 30;7:35-47. [2]. Ettinger B, et al. Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. J Urol. 1988 Apr;139(4):679-84. Chemical & Physical Properties Exact Mass 338.012817 PSA 117.87000 LogP -0.74 Index of Refraction 1.694 InChIKey JIVPVXMEBJLZRO-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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