CAS Number117467-28-4
SynonymsMeiact; Spectracef; Cefditoren pivoxil; Cefditoren pivoxyl; MFCD00933166; Cefditoren Pivaloyloxymethyl Ester; Cefditoren (Pivoxil)
Molecular FormulaC25H28N6O7S3
Molecular Weight620.72
Purity≥98 (HPLC)%
Density1.6±0.1 g/cm3
Melting Point207-209ºC
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 117467-28-4 |
| Catalog No. | 2A-9009632 |
| Chinese Name | 头孢妥仑匹酯 |
| Synonyms | Meiact; Spectracef; Cefditoren pivoxil; Cefditoren pivoxyl; MFCD00933166; Cefditoren Pivaloyloxymethyl Ester; Cefditoren (Pivoxil) |
| Molecular Formula | C25H28N6O7S3 |
| Molecular Weight | 620.72 |
| Purity | ≥98 (HPLC) |
| Density | 1.6±0.1 g/cm3 |
| Melting Point | 207-209ºC |
| Appearance | powder |
| Water Solubility | Water solubility: insoluble; slightly soluble: met |
| Storage Condition | -20?C Freezer |
| Application | Cefditoren is a new third-generation cephalosporin antibiotic with broad-spectrum activity against both Gram-positive and Gram-negative bacteria. |
| HTC | 2941905990 |
| SMILES | [s]1c(nc(c1)\C(=N\OC)\C(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)OCOC(=O)C(C)(C)C)\C=C/c4[s]cnc4C)N |
| InChI | 1S/C25H28N6O7S3/c1-12-15(41-10-27-12)7-6-13-8-39-21-17(29-19(32)16(30-36-5)14-9-40-24(26)28-14)20(33)31(21)18(13)22(34)37-11-38-23(35)25(2,3)4/h6-7,9-10,17,21H,8,11H2,1-5H3,(H2,26,28)(H,29,32)/b7-6-,30-16-/t17-,21-/m1/s1 |
| InChI Key | AFZFFLVORLEPPO-UVYJNCLZSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 51111800 |
| MSDS | msds/9632_1_117467_28_4.pdf |
| Bioactivity | Cefditoren pivoxil is a new-third generation cephalosporin antibiotic that has a broad spectrum of activity against Gram-positive and Gram-negative bacteria, including common respiratory and skin pathogens.Target: AntibacterialCefditoren pivoxil, a new-third generation cephalosporin antibiotic that has recently been granted approval in Spain, shows important activity over a large part of the pathogens causing skin, soft tissue and respiratory tract infections, including Gram-negative and Gram-positive bacteria. Cefditoren is also marketed under the name Meiact. Cefditoren has a broad spectrum of activity and has been used to treat bacterial infections of the skin and respiratory tract including bronchitis, pneumonia, and tonsillitis. The following represents MIC susceptibility data for a few medically significant microorganisms.Cefditoren has shown excellent in vitro activity against the Gram-positive pathogens penicillin-susceptible and -intermediate Streptococcus pneumoniae, S. pyogenes and methicillin-susceptible Staphylococcus aureus. Cefditoren was inactive against methicillin-resistant S. aureus. Of the important Gram-negative pathogens, cefditoren had potent antibacterial effects against beta-lactamase-positive and -negative Haemophilus influenzae, H. parainfluenzae and beta-lactamase-positive and -negative Moraxella catarrhalis. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Hernández-Martin J, et al. Cefditoren pivoxil: A new oral cephalosporin for skin, soft tissue and respiratory tract infections. Rev Esp Quimioter. 2006 Sep;19(3):231-46. [2]. Darkes MJ, et al. Cefditoren pivoxil. Drugs. 2002;62(2):319-36; discussion 337-8. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Melting Point 207-209ºC Molecular Formula C25H28N6O7S3 Molecular Weight 620.721 Exact Mass 620.118164 PSA 257.18000 LogP 2.74 Index of Refraction 1.710 InChIKey AFZFFLVORLEPPO-SJESJDBISA-N SMILES CON=C(C(=O)NC1C(=O)N2C(C(=O)OCOC(=O)C(C)(C)C)=C(C=Cc3scnc3C)CSC12)c1csc(N)n1 Storage condition -20?C Freezer |
| Use of | Cefditoren pivoxil is a new-third generation cephalosporin antibiotic that has a broad spectrum of activity against Gram-positive and Gram-negative bacteria, including common respiratory and skin pathogens.Target: AntibacterialCefditoren pivoxil, a new-third generation cephalosporin antibiotic that has recently been granted approval in Spain, shows important activity over a large part of the pathogens causing skin, soft tissue and respiratory tract infections, including Gram-negative and Gram-positive bacteria. Cefditoren is also marketed under the name Meiact. Cefditoren has a broad spectrum of activity and has been used to treat bacterial infections of the skin and respiratory tract including bronchitis, pneumonia, and tonsillitis. The following represents MIC susceptibility data for a few medically significant microorganisms.Cefditoren has shown excellent in vitro activity against the Gram-positive pathogens penicillin-susceptible and -intermediate Streptococcus pneumoniae, S. pyogenes and methicillin-susceptible Staphylococcus aureus. Cefditoren was inactive against methicillin-resistant S. aureus. Of the important Gram-negative pathogens, cefditoren had potent antibacterial effects against beta-lactamase-positive and -negative Haemophilus influenzae, H. parainfluenzae and beta-lactamase-positive and -negative Moraxella catarrhalis. Properties Name cefditoren pivoxil Synonym More Synonyms Cefditoren pivoxil Biological Activity Description Cefditoren pivoxil is a new-third generation cephalosporin antibiotic that has a broad spectrum of activity against Gram-positive and Gram-negative bacteria, including common respiratory and skin pathogens.Target: AntibacterialCefditoren pivoxil, a new-third generation cephalosporin antibiotic that has recently been granted approval in Spain, shows important activity over a large part of the pathogens causing skin, soft tissue and respiratory tract infections, including Gram-negative and Gram-positive bacteria. Cefditoren is also marketed under the name Meiact. Cefditoren has a broad spectrum of activity and has been used to treat bacterial infections of the skin and respiratory tract including bronchitis, pneumonia, and tonsillitis. The following represents MIC susceptibility data for a few medically significant microorganisms.Cefditoren has shown excellent in vitro activity against the Gram-positive pathogens penicillin-susceptible and -intermediate Streptococcus pneumoniae, S. pyogenes and methicillin-susceptible Staphylococcus aureus. Cefditoren was inactive against methicillin-resistant S. aureus. Of the important Gram-negative pathogens, cefditoren had potent antibacterial effects against beta-lactamase-positive and -negative Haemophilus influenzae, H. parainfluenzae and beta-lactamase-positive and -negative Moraxella catarrhalis. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Hernández-Martin J, et al. Cefditoren pivoxil: A new oral cephalosporin for skin, soft tissue and respiratory tract infections. Rev Esp Quimioter. 2006 Sep;19(3):231-46. [2]. Darkes MJ, et al. Cefditoren pivoxil. Drugs. 2002;62(2):319-36; discussion 337-8. Chemical & Physical Properties Molecular Formula C25H28N6O7S3 Exact Mass 620.118164 PSA 257.18000 Index of Refraction 1.710 InChIKey AFZFFLVORLEPPO-SJESJDBISA-N Storage condition -20?C Freezer |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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