CAS Number42540-40-9
SynonymsMandokef; Cefam; cephamandole nafate; EINECS 255-877-4; Cefamandole nafate; O-Formylcefamandole sodium; Bergacef; Cedol; Cemandil; CefamandoleNafate; Cefamandole formate sodium; Mandol; Cemandil sodium salt; Cefaseptolo; Sodium O-formylcefamandole; Mandolsan; UNII-8HDO7941DO; Cefamandole formate sodium salt; Kefadol; MFCD00864877; Cefamandole (nafate)
Molecular FormulaC19H17N6O6S2Na
Molecular Weight512.49
Purity98%
Melting Point190-193ºC
Appearancewhite solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 42540-40-9 |
| Catalog No. | 2A-9009626 |
| Chinese Name | 头孢孟多酯钠 |
| Synonyms | Mandokef; Cefam; cephamandole nafate; EINECS 255-877-4; Cefamandole nafate; O-Formylcefamandole sodium; Bergacef; Cedol; Cemandil; CefamandoleNafate; Cefamandole formate sodium; Mandol; Cemandil sodium salt; Cefaseptolo; Sodium O-formylcefamandole; Mandolsan; UNII-8HDO7941DO; Cefamandole formate sodium salt; Kefadol; MFCD00864877; Cefamandole (nafate) |
| Molecular Formula | C19H17N6O6S2Na |
| Molecular Weight | 512.49 |
| Purity | 98 |
| Melting Point | 190-193ºC |
| Appearance | white solid |
| Storage Condition | -20?C Freezer, Under Inert Atmosphere |
| Application | Cefamandole sodium salt is a second-generation broad-spectrum cephalosporin antibiotic. |
| HTC | 3003201900 |
| PubChem ID | 329774810 |
| MDL Number | MFCD00864877 |
| SMILES | [Na+].Cn1nnnc1SCC2=C(N3C(SC2)[C@H](NC(=O)[C@H](OC=O)c4ccccc4)C3=O)C([O-])=O |
| InChI | 1S/C19H18N6O6S2.Na/c1-24-19(21-22-23-24)33-8-11-7-32-17-12(16(28)25(17)13(11)18(29)30)20-15(27)14(31-9-26)10-5-3-2-4-6-10;/h2-6,9,12,14,17H,7-8H2,1H3,(H,20,27)(H,29,30);/q;+1/p-1/t12-,14-,17-;/m1./s1 |
| InChI Key | ICZOIXFFVKYXOM-YCLOEFEOSA-M |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/9626_1_42540_40_9.pdf |
| Use of | Cefamandole nafate is a second-generation broad-spectrum cephalosporin antibiotic. Properties Name cefamandole nafate Synonym More Synonyms Cefamandole nafate Biological Activity Description Cefamandole nafate is a second-generation broad-spectrum cephalosporin antibiotic. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Chemical & Physical Properties Molecular Formula C19H17N6NaO6S2 Exact Mass 512.054871 PSA 210.04000 InChIKey FUWWBXJEMYXCMO-YCLOEFEOSA-N Storage condition -20?C Freezer, Under Inert Atmosphere Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((formyloxy)phenylacetyl)amino)-3- (((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, monosodium salt, (6R-(6-alpha,7-beta(R)))- CAS REGISTRY NUMBER : 42540-40-9 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C19-H18-N6-O6-S2.Na MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Musculoskeletal - joints REFERENCE : SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 78,1268,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - man DOSE/DURATION : 400 ug/kg/1W-I TOXIC EFFECTS : Liver - jaundice, other or unclassified REFERENCE : DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 19,553,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Blood - change in clotting factors REFERENCE : AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 146,1125,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - man DOSE/DURATION : TOXIC EFFECTS : Blood - change in clotting factors REFERENCE : AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 146,1125,1986 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Blood - pigmented or nucleated red blood cells Blood - other changes Blood - changes in erythrocyte (RBC) count REFERENCE : JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Blood - pigmented or nucleated red blood cells Blood - other changes Blood - changes in erythrocyte (RBC) count REFERENCE : JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3878 No. of Facilities: 599 (estimated) No. of Industries: 1 No. of Occupations: 7 No. of Employees: 29927 (estimated) No. of Female Employees: 24672 (estimated) Safety Information GHS07, GHS08 Signal Word Danger Hazard Statements H315-H317-H319-H334-H335 Precautionary Statements P261-P280-P284-P304 + P340-P305 + P351 + P338-P342 + P311 Hazard Codes Xn Safety Phrases 26-36 RIDADR NONH for all modes of transport WGK Germany 3 RTECS XI0380000 HS Code 3003201900 Synthetic Route [6R-[6alpha,7be... CAS#:57268-80-1 Cefamandole nafate CAS#:42540-40-9 CAS#:24209-38-9 Cefamandole nafate CAS#:42540-40-9 (R)-methyl mandelate CAS#:20698-91-3 Cefamandole nafate CAS#:42540-40-9 Precursor & DownStream Precursor 4 CAS#:57268-80-1 [6R-[6alpha,7be... CAS#:24209-38-9 CAS#:20698-91-3 (R)-methyl mandelate CAS#:65338-32-1 cefamandole DownStream 0 |
| Transport Info | Product Name: Cefamandoxate Sodium |
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