CAS Number514-78-3
SynonymsMFCD00016364; Canthaxanthin; all-trans-Canthaxanthin; EINECS 208-187-2
Molecular FormulaC40H52O2
Molecular Weight564.84
Purity≥95.0 (HPLC)%
Density1.0±0.1 g/cm3
Boiling Point717.0±40.0 °C at 760 mmHg
Appearancepowder or crystals
EINECS208-187-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 514-78-3 |
| Catalog No. | 2A-9009560 |
| Chinese Name | 斑蝥黄(反式) |
| Synonyms | MFCD00016364; Canthaxanthin; all-trans-Canthaxanthin; EINECS 208-187-2 |
| Molecular Formula | C40H52O2 |
| Molecular Weight | 564.84 |
| Purity | ≥95.0 (HPLC) |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 717.0±40.0 °C at 760 mmHg |
| Appearance | powder or crystals |
| Storage Condition | Store in a cool, dry, well-ventilated warehouse. K |
| Packaging | II |
| Application | Canthaxanthin is a red-orange carotenoid with multiple biological activities, such as antioxidant and anti-tumor activities. |
| EINECS | 208-187-2 |
| HTC | 3204199000 |
| PubChem ID | 329749552 |
| MDL Number | MFCD00016364 |
| SMILES | CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C(=O)CCC1(C)C)\C=C\C=C(C)\C=C\C2=C(C)C(=O)CCC2(C)C |
| InChI | 1S/C40H52O2/c1-29(17-13-19-31(3)21-23-35-33(5)37(41)25-27-39(35,7)8)15-11-12-16-30(2)18-14-20-32(4)22-24-36-34(6)38(42)26-28-40(36,9)10/h11-24H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+ |
| InChI Key | FDSDTBUPSURDBL-DKLMTRRASA-N |
| Beilstein/REAXYS | 1898520 |
| NACRES Code | NA.32 |
| UNSPSC | 12352202 |
| Hazard Symbols | 6.1 |
| MSDS | msds/9560_1_514_78_3.pdf |
| Bioactivity | Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Terpenoids and Glycosides Research Areas >> Cancer Research Areas >> Inflammation/Immunology In Vitro Canthaxanthin enrichment of LDL has the potential to protect cholesterol from oxidation. In addition to its free radical scavenging and antioxidant properties (e.g., the induction of catalase and superoxide dismutase), canthaxanthin shows immunomodulatory activity (e.g. enhancing the proliferation and function of immune competent cells) and plays important role in gap junction communication (e.g. induction of the transmembrane protein connexin)[1]. At concentrations of 0.1 to 1 x 1000 μM, canthaxanthin significantly reduces the overall number of tumor cells. The greatest inhibition is observed at a canthaxanthin concentration of 1000 after 72 h and 96 h of incubation[2]. In Vivo Canthaxanthin alters the protective ability of tissues against oxidative stress. Canthaxanthin treatment for 15 d at the dose of 14 μg/kg body weight results in hepatic incorporation of the carotenoid, which is maximum in liver and reaches 0.52 ± 0.05 nmol/g liver. Glutathione peroxidase activity is 35% lower and catalase (59%) and manganese superoxide dismutase (28%) activities are higher in canthaxanthin-treated mice than in controls[3]. Canthaxanthin inhibit the growth of mammary tumors in mice and the anti-tumor activity is also influenced by the supplemental dose[4]. Diet supplementation with canthaxanthin for 3 weeks prior to the carcinogen results in a 65% reduction in the number of mammary cancers by a mechanism not involving pro-vitamin A activity[5]. Animal Admin Mice: Female 6-wk-old Balb/c mice are randomly divided into two groups (n = 10/group). The control group receives olive oil alone (vehicle) and the canthaxanthin-treated group receives canthaxanthin at a dose of 14 μg/kg body weight per day. At the end of the treatment, mice are killed by cervical dislocation and liver is excised, frozen in liquid nitrogen and stored at −80°C[3]. References [1]. Esatbeyoglu T, et al. Canthaxanthin: From molecule to function. Mol Nutr Food Res. 2017 Jun;61(6). [2]. Huang DS, et al. Inhibitory effects of canthaxanthin on in vitro growth of murine tumor cells. Cancer Lett. 1992 Aug 31;65(3):209-13. [3]. Palozza P, et al. Canthaxanthin supplementation alters antioxidant enzymes and iron concentration in liver of Balb/c mice. J Nutr. 2000 May;130(5):1303-8. [4]. Chew BP, et al. A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. Anticancer Res. 1999 May-Jun;19(3A):1849-53. [5]. Grubbs CJ, et al. Effect of canthaxanthin on chemically induced mammary carcinogenesis. Oncology. 1991;48(3):239-45. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 717.0±40.0 °C at 760 mmHg Molecular Formula C40H52O2 Molecular Weight 564.840 Flash Point 253.9±24.3 °C Exact Mass 564.396729 PSA 34.14000 LogP 10.69 Vapour Pressure 0.0±2.3 mmHg at 25°C Index of Refraction 1.575 Storage condition 0-6°C |
| Use of | Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties. Properties Articles29 Name canthaxanthin Synonym More Synonyms Canthaxanthin Biological Activity Description Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Terpenoids and Glycosides Research Areas >> Cancer Research Areas >> Inflammation/Immunology In Vitro Canthaxanthin enrichment of LDL has the potential to protect cholesterol from oxidation. In addition to its free radical scavenging and antioxidant properties (e.g., the induction of catalase and superoxide dismutase), canthaxanthin shows immunomodulatory activity (e.g. enhancing the proliferation and function of immune competent cells) and plays important role in gap junction communication (e.g. induction of the transmembrane protein connexin)[1]. At concentrations of 0.1 to 1 x 1000 μM, canthaxanthin significantly reduces the overall number of tumor cells. The greatest inhibition is observed at a canthaxanthin concentration of 1000 after 72 h and 96 h of incubation[2]. References [1]. Esatbeyoglu T, et al. Canthaxanthin: From molecule to function. Mol Nutr Food Res. 2017 Jun;61(6). [2]. Huang DS, et al. Inhibitory effects of canthaxanthin on in vitro growth of murine tumor cells. Cancer Lett. 1992 Aug 31;65(3):209-13. [3]. Palozza P, et al. Canthaxanthin supplementation alters antioxidant enzymes and iron concentration in liver of Balb/c mice. J Nutr. 2000 May;130(5):1303-8. [4]. Chew BP, et al. A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. Anticancer Res. 1999 May-Jun;19(3A):1849-53. [5]. Grubbs CJ, et al. Effect of canthaxanthin on chemically induced mammary carcinogenesis. Oncology. 1991;48(3):239-45. Chemical & Physical Properties Molecular Formula C40H52O2 Exact Mass 564.396729 PSA 34.14000 LogP 10.69 Index of Refraction 1.575 |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Cambendazole | 26097-80-3 | 2A-9009553 |
| Camostat | 59721-28-7 | 2A-9009554 |
| Camptothecin, 9-nitro-20(S) | 104195-61-1 | 2A-9009555 |
| Cananga oil | 8006-81-3 | 2A-9009556 |
| Canrenone | 976-71-6 | 2A-9009559 |
| Capobenic acid | 21434-91-3 | 2A-9009562 |
| Capromab | 151763-64-3 | 2A-9009563 |
| Capsanthin | 465-42-9 | 2A-9009564 |
| Captafol | 2425-06-1 | 2A-9009565 |
| Carafiban | 177563-40-5 | 2A-9009568 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS