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Calcifediol structure, CAS 19356-17-3

Calcifediol

CAS Number19356-17-3

SynonymsDidrogyl; (3S,5Z,7E,20R)-9,10-Secocholesta-5,7,10-triene-3,25-diol; 25-hydroxyvitamin D3; Ro 8-8892; 25-HCC; U 32070E; (3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3,25-diol; 25-hydroxycholecalciferol; 9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-3β,25-DIOL; MFCD00867077; CALCIDIOL; Dedrogyl; 25-hydroxyvitamin D; 25-hydroxy-cholecalciferol; 9,10-Secocholesta-5,7,10(19)-triene-3b,25-diol; Calderol; Calcifediol; U-32070E; EINECS 242-990-9; Calcidiol,Didrogyl,Hidroferol; Hidroferol

Molecular FormulaC27H44O2

Molecular Weight400.64

Purity≥98 (HPLC)%

Density1.0±0.1 g/cm3

Boiling Point529.2±33.0 °C at 760 mmHg

Melting Point74-76oC

Flash Point

Appearancepowder

EINECS242-990-9

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9009537 Purity: ≥98 (HPLC)%
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Quality Control of [ 19356-17-3 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number19356-17-3
Catalog No.2A-9009537
Chinese Name骨化二醇
SynonymsDidrogyl; (3S,5Z,7E,20R)-9,10-Secocholesta-5,7,10-triene-3,25-diol; 25-hydroxyvitamin D3; Ro 8-8892; 25-HCC; U 32070E; (3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3,25-diol; 25-hydroxycholecalciferol; 9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-3β,25-DIOL; MFCD00867077; CALCIDIOL; Dedrogyl; 25-hydroxyvitamin D; 25-hydroxy-cholecalciferol; 9,10-Secocholesta-5,7,10(19)-triene-3b,25-diol; Calderol; Calcifediol; U-32070E; EINECS 242-990-9; Calcidiol,Didrogyl,Hidroferol; Hidroferol
Molecular FormulaC27H44O2
Molecular Weight400.64
Purity≥98 (HPLC)
Density1.0±0.1 g/cm3
Boiling Point529.2±33.0 °C at 760 mmHg
Melting Point74-76oC
Appearancepowder
Storage Condition−20°C
PackagingⅡ
ApplicationCalcifediol (25-hydroxy Vitamin D3) is a prohormone obtained by hydroxylation of vitamin D3 in the liver.
EINECS242-990-9
PubChem ID24895612
MDL NumberMFCD00867077
SMILESC[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C
InChI1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
InChI KeyJWUBBDSIWDLEOM-DTOXIADCSA-N
NACRES CodeNA.79
UNSPSC12352205
Hazard SymbolsTransport
MSDSmsds/9537_1_19356_17_3.pdf
BioactivityCalcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM). Related Catalog Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Metabolic Disease Natural Products >> Others Target Human Endogenous Metabolite In Vitro Calcifediol in either liposomes or ethanolic solution has no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells. Treatment of infected, human bronchial 16-HBE cells with Calcifediol liposomes results in a significant reduction in bacterial survival[1]. References [1]. Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 529.2±33.0 °C at 760 mmHg Melting Point 74-76oC Molecular Formula C27H44O2 Molecular Weight 400.637 Flash Point 221.4±20.0 °C Exact Mass 400.334137 PSA 40.46000 LogP 7.53 Vapour Pressure 0.0±3.2 mmHg at 25°C Index of Refraction 1.536 InChIKey JWUBBDSIWDLEOM-UHFFFAOYSA-N SMILES C=C1CCC(O)CC1=CC=C1CCCC2(C)C1CCC2C(C)CCCC(C)(C)O Storage condition −20°C
Use ofCalcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM). Properties Articles74 Name calcidiol Synonym More Synonyms Calcifediol Biological Activity Description Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM). Related Catalog Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Metabolic Disease Natural Products >> Others Human Endogenous Metabolite In Vitro Calcifediol in either liposomes or ethanolic solution has no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells. Treatment of infected, human bronchial 16-HBE cells with Calcifediol liposomes results in a significant reduction in bacterial survival[1]. References [1]. Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22. Chemical & Physical Properties Molecular Formula C27H44O2 Exact Mass 400.334137 PSA 40.46000 Index of Refraction 1.536 InChIKey JWUBBDSIWDLEOM-UHFFFAOYSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1170 International Maritime Transport Danger Regulations: 1170 International Air Transport Danger Regulations: 1170 14.2 United Nations shipping name European Land Transport Danger Regulations: ETHANOL SOLUTION International Maritime Dangerous Regulations: ETHANOL SOLUTION International Air Transport Danger Regulations: Ethanol solution 14.3 Transport hazard categories European land transport Dangerous Regulations: 3 International sea transport Dangerous Regulations: 3 International air transport Dangerous Regulations: 3 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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