Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > (2R,3R,4R,5R)-2-(ACETOXYMETHYL)-5-(2-AMINO-6-CHLORO-9H-PURIN-9-YL)TETRAHYDROFURAN-3,4-DIYL DIACETATE

(2R,3R,4R,5R)-2-(ACETOXYMETHYL)-5-(2-AMINO-6-CHLORO-9H-PURIN-9-YL)TETRAHYDROFURAN-3,4-DIYL DIACETATE

Name: (2R,3R,4R,5R)-2-(ACETOXYMETHYL)-5-(2-AMINO-6-CHLORO-9H-PURIN-9-YL)TETRAHYDROFURAN-3,4-DIYL DIACETATE
Brand: 2A Biotech
SKU: 2A-0095118

CAS Number16321-99-6

Synonyms2',3',5'-Tri-O-acetyl-2-amino-6-chloropurine Riboside; 2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine; [(2R,3S,4S,5R)-3,4-diacetyloxy-5-(2-amino-6-chloropurin-9-yl)oxolan-2-yl]methyl acetate

Molecular FormulaC16H18O7N5Cl1

Molecular Weight427.8

Purity96+%

Density1.7g/cm3

Boiling Point637ºC at 760mmHg

Melting Point146.0 to 150.0 °C

AppearanceSolid;Light orange to Yellow to Green powder to crystal

EINECS0

MSDSChinese English

Cat. No.: 2A-0095118 Purity: 96+%

Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Quality Control of [ 16321-99-6 ] Purity: 96+% SDS Specification MoL

Chemical & Physical Properties
CAS Number	16321-99-6
Catalog No.	2A-0095118
Chinese Name	2',3',5'-三-O-乙酰-2-氨基-6-氯嘌呤核苷
Synonyms	2',3',5'-Tri-O-acetyl-2-amino-6-chloropurine Riboside; 2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine; [(2R,3S,4S,5R)-3,4-diacetyloxy-5-(2-amino-6-chloropurin-9-yl)oxolan-2-yl]methyl acetate
Molecular Formula	C16H18O7N5Cl1
Molecular Weight	427.8
Purity	96+
Density	1.7g/cm3
Boiling Point	637ºC at 760mmHg
Melting Point	146.0 to 150.0 °C
Appearance	Solid;Light orange to Yellow to Green powder to crystal
Storage Condition	room temperature, dry
Application	2′,3′,5′-Tri-O-acetyl-6-chloroguanosine diacetate is a purine nucleoside analog. Purine nucleoside analogues have broad antitumor activity and target indolent lymphoid malignancies. The anti-cancer me
EINECS	0
HTC	0
UN(IATA)	0
PubChem ID	15827441
MDL Number	MFCD03425473
SMILES	CC(=O)OCC1OC(n2cnc3c(Cl)nc(N)nc32)C(OC(C)=O)C1OC(C)=O
InChI	InChI=1S/C16H18ClN5O7/c1-6(23)26-4-9-11(27-7(2)24)12(28-8(3)25)15(29-9)22-5-19-10-13(17)20-16(18)21-14(10)22/h5,9,11-12,15H,4H2,1-3H3,(H2,18,20,21)
InChI Key	HLVGVJFVAKPFOZ-SDBHATRESA-N
MSDS	msds/95118_1_16321_99_6.pdf
Bioactivity	2′,3′,5′-Tri-O-acetyl-6-chloroguanosine diacetate is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog References [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. Chemical & Physical Properties Density 1.7g/cm3 Boiling Point 637ºC at 760mmHg Melting Point 146.0 to 150.0 °C Molecular Formula C16H18ClN5O7 Molecular Weight 427.80 Flash Point 339ºC Exact Mass 427.08900 PSA 157.75000 LogP 0.96700 Vapour Pressure 4E-16mmHg at 25°C Index of Refraction 1.69 InChIKey HLVGVJFVAKPFOZ-SDBHATRESA-N SMILES CC(=O)OCC1OC(n2cnc3c(Cl)nc(N)nc32)C(OC(C)=O)C1OC(C)=O
Use of	2′,3′,5′-Tri-O-acetyl-6-chloroguanosine diacetate is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. Properties Name (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2-amino-6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate Synonym More Synonyms Biological Activity Description 2′,3′,5′-Tri-O-acetyl-6-chloroguanosine diacetate is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog References [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. Chemical & Physical Properties Exact Mass 427.08900 PSA 157.75000 LogP 0.96700 Index of Refraction 1.69 InChIKey HLVGVJFVAKPFOZ-SDBHATRESA-N
Transport Info	Product name: 2',3',5'-Tri-O-acetyl-2-amino-6-chloropurine nucleoside

Related Products in Pharmaceutical Intermediates
(2R,3R)-TERT-BUTYL 3-AMINO-2-HYDROXY-3-PHENYLPROPANOATE	135981-02-1	2A-0095108
(2R,3R,4R)-2-(((TERT-BUTYLDIPHENYLSILYL)OXY)METHYL)-3,4-DIHYDRO-2H-PYRAN-3,4-DIOL	137893-35-7	2A-0095109
(2R,3R,4R)-2-(((TRIISOPROPYLSILYL)OXY)METHYL)-3,4-DIHYDRO-2H-PYRAN-3,4-DIOL	166021-01-8	2A-0095110
(2R,3R,4R)-4-((TERT-BUTYLDIMETHYLSILYL)OXY)-2-(((TERT-BUTYLDIMETHYLSILYL)OXY)METHYL)-3,4-DIHYDRO-2H-PYRAN-3-YL ACETATE	132891-79-3	2A-0095112
(2R,3R,4R,5R)-2-(2-ACETAMIDO-6-CHLORO-9H-PURIN-9-YL)-5-(ACETOXYMETHYL)TETRAHYDROFURAN-3,4-DIYL DIACETATE	137896-02-7	2A-0095117
(2R,3R,4R,5R)-2-(ACETOXYMETHYL)-5-(4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)TETRAHYDROFURAN-3,4-DIYL DIACETATE	16754-79-3	2A-0095119
(2R,3R,4R,5R)-2-METHOXYTETRAHYDRO-2H-PYRAN-3,4,5-TRIOL	17289-61-1	2A-0095121
(2R,3R,4R,5R,6S)-6-METHYLTETRAHYDRO-2H-PYRAN-2,3,4,5-TETRAOL	6014-42-2	2A-1095130
(2R,3R,4R,5S)-6-(ETHYLAMINO)HEXANE-1,2,3,4,5-PENTAOL	14216-22-9	2A-0095132
(2R,3R,4R,5S,6S)-2-(ACETOXYMETHYL)-6-(4-CHLORO-3-(4-ETHOXYBENZYL)PHENYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIYL TRIACETATE	461432-25-7	2A-1095135
Browse all Pharmaceutical Intermediates products »

(2R,3R,4R,5R)-2-(ACETOXYMETHYL)-5-(2-AMINO-6-CHLORO-9H-PURIN-9-YL)TETRAHYDROFURAN-3,4-DIYL DIACETATE

Inquiry Form