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Bergenin structure, CAS 477-90-7

Bergenin

CAS Number477-90-7

SynonymsVakerin; Ai Cha Su; Bergenitol; Bergenit; CORYLOPSIN; (+)-Bergenin; 4-Methoxy-2-[tetrahydro-3,4,5-trihydroxy-6-(hydroxymethyl)pyran-2-yl]-a-resorcylic Acid d-Lactone; BERGENIN; CUSCUTIN; Ardisic Acid B; MFCD00133120

Molecular FormulaC14H16O9

Molecular Weight328.27

Purity≥95 (LC/MS-ELSD)%

Density1.6±0.1 g/cm3

Boiling Point658.9±55.0 °C at 760 mmHg

Melting Point237-240 °C(lit.)

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9009372 Purity: ≥95 (LC/MS-ELSD)%
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Quality Control of [ 477-90-7 ] Purity: ≥95 (LC/MS-ELSD)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number477-90-7
Catalog No.2A-9009372
Chinese Name岩白菜素
SynonymsVakerin; Ai Cha Su; Bergenitol; Bergenit; CORYLOPSIN; (+)-Bergenin; 4-Methoxy-2-[tetrahydro-3,4,5-trihydroxy-6-(hydroxymethyl)pyran-2-yl]-a-resorcylic Acid d-Lactone; BERGENIN; CUSCUTIN; Ardisic Acid B; MFCD00133120
Molecular FormulaC14H16O9
Molecular Weight328.27
Purity≥95 (LC/MS-ELSD)
Density1.6±0.1 g/cm3
Boiling Point658.9±55.0 °C at 760 mmHg
Melting Point237-240 °C(lit.)
Appearancesolid
Storage ConditionBrown glass bottle with light-sealed packaging. St
ApplicationBergenin is a polyphenol with antioxidant activity. In Plasmodium activity, IC50 < 2.5 μM.
PubChem ID329824752
MDL NumberMFCD00133120
SMILESO1[C@@H]2[C@H](OC(=O)c3c2c(c(c(c3)O)OC)O)[C@H]([C@@H]([C@H]1CO)O)O
InChI1S/C14H16O9/c1-21-11-5(16)2-4-7(9(11)18)12-13(23-14(4)20)10(19)8(17)6(3-15)22-12/h2,6,8,10,12-13,15-19H,3H2,1H3/t6-,8-,10+,12+,13-/m1/s1
InChI KeyYWJXCIXBAKGUKZ-HJJNZUOJSA-N
NACRES CodeNA.25
UNSPSC12352205
MSDSmsds/9372_1_477_90_7.pdf
BioactivityBergenin, a polyphenol, is a potent antinarcotic agent with antioxidant action. IC50 value: < 2.5 μM (antiplasmodial) [3]Target:In vitro: The naloxone-precipitated withdrawal symptom (jumping frequency) was significantly ameliorated (50% of control group) by administration of bergenin (20 mg/kg) in morphine-treated mice. Furthermore, morphine-induced down-regulation of glutathione (GSH) contents was reversed by bergenin administration in the frontal cortex and liver [2].In vivo: Bergenin attenuated inflammatory cell infiltration and decreased the concentration of NO, TNF-α, IL-1β, and IL-6, which were increased in LPS-induced mouse mastitis [1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others Natural Products >> Phenylpropanoids References [1]. Gao XJ, et al. Bergenin Plays an Anti-Inflammatory Role via the Modulation of MAPK and NF-κB Signaling Pathways in a Mouse Model of LPS-Induced Mastitis. Inflammation. 2015 Jun;38(3):1142-50. [2]. Yun J, et al. Bergenin decreases the morphine-induced physical dependence via antioxidative activity in mice. Arch Pharm Res. 2015 Jun;38(6):1248-54. [3]. Uddin G, et al. Comparative antioxidant and antiplasmodial activities of 11-O-galloylbergenin and bergenin isolated from Bergenia ligulata. Trop Biomed. 2014 Mar;31(1):143-8. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 658.9±55.0 °C at 760 mmHg Melting Point 237-240 °C(lit.) Molecular Formula C14H16O9 Molecular Weight 328.271 Flash Point 250.7±25.0 °C Exact Mass 328.079437 PSA 145.91000 LogP 0.05 Vapour Pressure 0.0±2.1 mmHg at 25°C Index of Refraction 1.655 InChIKey YWJXCIXBAKGUKZ-HJJNZUOJSA-N SMILES COc1c(O)cc2c(c1O)C1OC(CO)C(O)C(O)C1OC2=O Storage condition ?20°C
Use ofProperties Articles36 Name Bengenin Synonym More Synonyms Bergenin Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others Natural Products >> Phenylpropanoids References [1]. Gao XJ, et al. Bergenin Plays an Anti-Inflammatory Role via the Modulation of MAPK and NF-κB Signaling Pathways in a Mouse Model of LPS-Induced Mastitis. Inflammation. 2015 Jun;38(3):1142-50. [2]. Yun J, et al. Bergenin decreases the morphine-induced physical dependence via antioxidative activity in mice. Arch Pharm Res. 2015 Jun;38(6):1248-54. [3]. Uddin G, et al. Comparative antioxidant and antiplasmodial activities of 11-O-galloylbergenin and bergenin isolated from Bergenia ligulata. Trop Biomed. 2014 Mar;31(1):143-8. Chemical & Physical Properties Molecular Formula C14H16O9 Exact Mass 328.079437 PSA 145.91000 Index of Refraction 1.655 InChIKey YWJXCIXBAKGUKZ-HJJNZUOJSA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified petrosine
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