CAS Number115-33-3
Synonyms3,3-bis-(4-acetoxy-phenyl)-indolin-2-one; Izafenin; 3,3-bis[4-(acetyloxy)phenyl]-1,3-dihydro-2H-indol-2-one; Darmoletten; Diphesatine; Acetalax; Contax; Promassolax; 3,3-bis(4-acetoxyphenyl)oxindole; Brocatine; Isaphenin; OXYPHENISATIN ACETATE; EINECS 204-083-6; Diphesatin; 3,3-Bis-(4-acetoxy-phenyl)-indolin-2-on; oxyphenisatine di(acetate)
Molecular FormulaC24H19NO5
Molecular Weight401.41100
Purity98.00%%
Density1.282 g/cm3
Boiling Point566.5ºC at 760 mmHg
Melting Point244℃
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 115-33-3 |
| Catalog No. | 2A-9093685 |
| Chinese Name | 双醋酚丁 |
| Synonyms | 3,3-bis-(4-acetoxy-phenyl)-indolin-2-one; Izafenin; 3,3-bis[4-(acetyloxy)phenyl]-1,3-dihydro-2H-indol-2-one; Darmoletten; Diphesatine; Acetalax; Contax; Promassolax; 3,3-bis(4-acetoxyphenyl)oxindole; Brocatine; Isaphenin; OXYPHENISATIN ACETATE; EINECS 204-083-6; Diphesatin; 3,3-Bis-(4-acetoxy-phenyl)-indolin-2-on; oxyphenisatine di(acetate) |
| Molecular Formula | C24H19NO5 |
| Molecular Weight | 401.41100 |
| Purity | 98.00% |
| Density | 1.282 g/cm3 |
| Boiling Point | 566.5ºC at 760 mmHg |
| Melting Point | 244℃ |
| Storage Condition | 2-8℃ |
| Application | Oxyphenisatin acetate is a prodrug of oxyphenisatin, which was often used as a laxative. |
| HTC | 2933790090 |
| PubChem ID | 107784 |
| SMILES | CC(=O)Oc1ccc(C2(c3ccc(OC(C)=O)cc3)C(=O)Nc3ccccc32)cc1 |
| InChI | InChI=1S/C24H19NO5/c1-15(26)29-19-11-7-17(8-12-19)24(18-9-13-20(14-10-18)30-16(2)27)21-5-3-4-6-22(21)25-23(24)28/h3-14H,1-2H3,(H,25,28) |
| InChI Key | PHPUXYRXPHEJDF-UHFFFAOYSA-N |
| Use of | Oxyphenisatin acetate, the pro-drug of oxyphenisatin, is used to be a laxative. Properties Name [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate Synonym More Synonyms Oxyphenisatin acetate Biological Activity Description Oxyphenisatin acetate, the pro-drug of oxyphenisatin, is used to be a laxative. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Others In Vitro Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. In the estrogen receptor (ER) positive MCF7 and T47D cells, oxyphenisatin acetate induces TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Ten micromoles per liter Oxyphenisatin acetate treatment results in autophagy and mitochondrial dysfunction[1]. References [1]. Morrison BL, et al. Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis. Cancer Med. 2013 Oct;2(5):687-700. Chemical & Physical Properties Molecular Formula C24H19NO5 Exact Mass 401.12600 PSA 81.70000 LogP 3.96170 Index of Refraction 1.611 InChIKey PHPUXYRXPHEJDF-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information HS Code 2933790090 Synthetic Route Oxyphenisatine CAS#:125-13-3 Oxyphenisatin a... CAS#:115-33-3 CAS#:91-56-5 phenyl acetate CAS#:122-79-2 Oxyphenisatin a... CAS#:115-33-3 Oxyphenisatine CAS#:125-13-3 Ethanoic anhydride CAS#:108-24-7 Oxyphenisatin a... CAS#:115-33-3 Literature: Hoffmann-La Roche and Co. Patent: DE406210 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 14, p. 1412 Full Text Show Details Hoffmann-La Roche and Co. Patent: DE447539 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 15, p. 1693 Full Text Show Details Hoffmann-La Roche and Co. Patent: DE482435 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 2519 Precursor & DownStream Precursor 7 CAS#:125-13-3 Oxyphenisatine CAS#:91-56-5 CAS#:122-79-2 phenyl acetate CAS#:108-24-7 Ethanoic anhydride DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 9.0% Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
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