| Chemical & Physical Properties | |
|---|---|
| CAS Number | 19881-70-0 |
| Catalog No. | 2A-9093367 |
| Chinese Name | 3-氯-2,3-双(4-甲氧苯基)丙烯醛(Windorphen) |
| Synonyms | (Z)-3-chloro-2,3-bis(4-methoxyphenyl)propenal; 3-CHLORO-2,3-DI(4-METHOXYPHENYL)ACRYLALDEHYDE |
| Molecular Formula | C34H34ClNO7 |
| Molecular Weight | 604.106 |
| Density | 1.198g/cm3 |
| Boiling Point | 468.1ºC at 760mmHg |
| Melting Point | 160-163ºC |
| Storage Condition | -20°C, sealed, dry |
| Application | Windorphen is a Wnt/β-catenin signaling inhibitor that specifically targets the function of the C-terminal transactivation domain of β-catenin-1 but not β-catenin-2. Windorphen selectively targets p30 |
| HTC | 2913000090 |
| PubChem ID | 9310838 |
| MDL Number | MFCD02726317 |
| SMILES | COc1ccc(C(Cl)=C(C=O)c2ccc(OC)cc2)cc1 |
| InChI | InChI=1S/C17H15ClO3/c1-20-14-7-3-12(4-8-14)16(11-19)17(18)13-5-9-15(21-2)10-6-13/h3-11H,1-2H3/b17-16- |
| InChI Key | VNRALGZMXHFBPG-UHFFFAOYSA-N |
| MSDS | msds/93367_1_19881_70_0.pdf |
| Bioactivity | Windorphen is a Wnt/β-catenin signal inhibitor that specifically targets the function of the c-terminal transactivation domain of β-catenin-1 but not β-catenin-2. Windorphen selectively targets p300, disrupting the association of the mammalian β-catenin with p300 but not CBP[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Wnt Signaling Pathways >> Epigenetics >> Histone Acetyltransferase References [1]. Jijun Hao, et al. Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen. Cell Rep. 2013 Sep 12;4(5):898-904. Chemical & Physical Properties Density 1.198g/cm3 Boiling Point 468.1ºC at 760mmHg Melting Point 160-163ºC Molecular Formula C17H15ClO3 Molecular Weight 302.75 Flash Point 184.7ºC Exact Mass 302.07100 PSA 35.53000 LogP 4.00980 Vapour Pressure 6.15E-09mmHg at 25°C Index of Refraction 1.579 InChIKey VNRALGZMXHFBPG-UHFFFAOYSA-N SMILES COc1ccc(C(Cl)=C(C=O)c2ccc(OC)cc2)cc1 |
| Use of | Windorphen is a Wnt/β-catenin signal inhibitor that specifically targets the function of the c-terminal transactivation domain of β-catenin-1 but not β-catenin-2. Windorphen selectively targets p300, disrupting the association of the mammalian β-catenin with p300 but not CBP[1]. Properties Name 3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde Synonym More Synonyms Windorphen Biological Activity Description Windorphen is a Wnt/β-catenin signal inhibitor that specifically targets the function of the c-terminal transactivation domain of β-catenin-1 but not β-catenin-2. Windorphen selectively targets p300, disrupting the association of the mammalian β-catenin with p300 but not CBP[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Wnt Signaling Pathways >> Epigenetics >> Histone Acetyltransferase References [1]. Jijun Hao, et al. Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen. Cell Rep. 2013 Sep 12;4(5):898-904. Chemical & Physical Properties Exact Mass 302.07100 PSA 35.53000 LogP 4.00980 Index of Refraction 1.579 InChIKey VNRALGZMXHFBPG-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary HS: 2913000090 halogenated, sulphonated, nitrated or nitrosated derivatives of products of heading 2912 Educational tariff:17.0% Tax rebate rate:9.0% Regulatory conditions:none Most favored nation tariff:5.5% General tariff:30.0% |
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