![5-CHLORO-3-[(3,5-DIMETHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE structure, CAS 1055412-47-9](/structures/100000/93341_1_1055412_47_9.png)
CAS Number1055412-47-9
Synonyms5-Chloro-3-[(3,5-dimethylpyrrol-2-yl)methylene]-2-indolinone; 1H-Indole-2-carboxylic acid,5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]; 5-chloro-3-(3,5-dimethylphenyl-sulfonyl)indole-2-carboxylic acid; 5-chloro-3-(3,5-dimethyl-1H-pyrrol-2-yl-methylene)-1,3-dihydro-indol-2-one; 5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-1H-indole-2-carboxylic acid; 3-[(3,5-dimethylphenyl)sulfonyl]-1H-indole-2-carboxylic acid; SU 5614; SU5614
Molecular FormulaC15H13O1N2Cl1
Molecular Weight272.73
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1055412-47-9 |
| Catalog No. | 2A-9093341 |
| Chinese Name | SU-5614游离态 |
| Synonyms | 5-Chloro-3-[(3,5-dimethylpyrrol-2-yl)methylene]-2-indolinone; 1H-Indole-2-carboxylic acid,5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]; 5-chloro-3-(3,5-dimethylphenyl-sulfonyl)indole-2-carboxylic acid; 5-chloro-3-(3,5-dimethyl-1H-pyrrol-2-yl-methylene)-1,3-dihydro-indol-2-one; 5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-1H-indole-2-carboxylic acid; 3-[(3,5-dimethylphenyl)sulfonyl]-1H-indole-2-carboxylic acid; SU 5614; SU5614 |
| Molecular Formula | C15H13O1N2Cl1 |
| Molecular Weight | 272.73 |
| Storage Condition | 2-8°C, dry and sealed |
| Application | (Z)-SU5614 is a potent FLT3 inhibitor that selectively induces growth arrest, apoptosis and cell cycle arrest in Ba/F3 and AML cell lines expressing constitutively activated FLT3 [1]. |
| HTC | 2933990090 |
| PubChem ID | 11643921 |
| MDL Number | MFCD08443928 |
| InChI | InChI=1S/C15H13ClN2O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,1-2H3,(H,18,19)/b12-7- |
| InChI Key | XLBQNZICMYZIQT-GHXNOFRVSA-N |
| MSDS | msds/93341_1_1055412_47_9.pdf |
| Use of | (Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3[1]. Properties Name 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one Synonym More Synonyms SU 5614 Biological Activity Description (Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3[1]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3 References [1]. Spiekermann K, et al. The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3. Blood. 2003 Feb 15;101(4):1494-504. Chemical & Physical Properties Exact Mass 272.07200 PSA 48.38000 LogP 3.86270 Safety Information Hazard Statements H413 RIDADR NONH for all modes of transport HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| 4-acetamido-2,5-dimethoxybenzenesulphonyl chloride | 13279-58-8 | 2A-9093336 |
| N-NITROSODIETHYLAMINE | 55-18-5 | 2A-9093337 |
| cadmium selenide sulphide | 11112-63-3 | 2A-9093338 |
| SRPK inhibitor | 218156-96-8 | 2A-9093339 |
| NQDI 1 | 175026-96-7 | 2A-9093340 |
| PR-619 | 2645-32-1 | 2A-9093342 |
| RI-1 | 415713-60-9 | 2A-9093343 |
| N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide | 72926-24-0 | 2A-9093344 |
| AMMONIUM CERIUM(IV) SULFATE | 7637-03-8 | 2A-9093345 |
| Benzeneacetamide, -alpha--cyano- | 771-84-6 | 2A-9093346 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS