CAS Number218156-96-8
Synonyms3,4-Dipropoxy-3-cyclobuten-1,2-dion; 4-Pyridinecarboxamide (N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]; squaric acid dibutyl ester; N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide; 1,2-di-n-propoxy-cyclobutenedione; di-n-propyl squarate; (SRPIN)340 N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide; N4-[2-piperidino-5-(trifluoromethyl)phenyl]isonicotinamide; 3-Cyclobutene-1,2-dione,3,4-dipropoxy; SRPIN-340; SRPIN340
Molecular FormulaC18H18F3N3O
Molecular Weight349.35
Purity≥98 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point395.9±42.0 °C at 760 mmHg
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 218156-96-8 |
| Catalog No. | 2A-9093339 |
| Chinese Name | SRPKINHIBITOR |
| Synonyms | 3,4-Dipropoxy-3-cyclobuten-1,2-dion; 4-Pyridinecarboxamide (N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]; squaric acid dibutyl ester; N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide; 1,2-di-n-propoxy-cyclobutenedione; di-n-propyl squarate; (SRPIN)340 N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide; N4-[2-piperidino-5-(trifluoromethyl)phenyl]isonicotinamide; 3-Cyclobutene-1,2-dione,3,4-dipropoxy; SRPIN-340; SRPIN340 |
| Molecular Formula | C18H18F3N3O |
| Molecular Weight | 349.35 |
| Purity | ≥98 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 395.9±42.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | SRPIN340 is an ATP-competitive SRPK inhibitor that inhibits the activity of SRPK1 with a Ki value of 0.89 μM. |
| PubChem ID | 329825465 |
| MDL Number | MFCD00116244 |
| SMILES | O=C(C1=CC=NC=C1)NC2=C(N3CCCCC3)C=CC(C(F)(F)F)=C2 |
| InChI | 1S/C18H18F3N3O/c19-18(20,21)14-4-5-16(24-10-2-1-3-11-24)15(12-14)23-17(25)13-6-8-22-9-7-13/h4-9,12H,1-3,10-11H2,(H,23,25) |
| InChI Key | DWFGGOFPIISJIT-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 51111800 |
| Hazard Symbols | transportation |
| MSDS | msds/93339_1_218156_96_8.pdf |
| Bioactivity | SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> SRPK Research Areas >> Cancer Target Ki: 0.89 μM (SRPK1)[1] In Vitro SRPIN340 is a serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1. SRPIN340 also inhibits SRPK2, but shows no significant inhibition on other SRPK, such as Clk1 and Clk4. SRPIN340 promotes degradation of SRp75, which is necessary for HIV expression. SRPIN340 suppresses the propagation of Sindbis virus (IC50, 60 μM) as well as severe acute respiratory syndrome virus[1]. SRPIN340 shows inhibitory effect on leukemia cell lines, such as AML HL60, ALL-T Molt4 and Jurkat, with IC50s of 44.7 μM, 92.2 μM and 82.3 μM, respectively[2]. Cell Assay Leukemic cells (5 × 104 cells/well) and isolated PBMCs (8 × 104 cells/well) are seeded in 96-well plates. Each well contained 100 μL of complete RPMI medium and 100 μL of SRPIN340 solution at different concentrations. The compound is diluted in RPMI medium with 10% fetal bovine serum and 0.4% DMSO (v/v). After 48 h of culture, MTT (5 mg/mL) is added to the wells (3 h, 37°C). The plates are centrifuged at room temperature for 30 min 500 ×g, followed by the removal of the MTT solution and the addition of 100 μL/well of DMSO to solubilize the formazan. Absorbance is measured at 540 nm in a microplate reader. Each experimental procedure is performed in triplicate[2]. References [1]. Fukuhara T, et al. Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11329-33. [2]. Siqueira RP, et al. Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340). PLoS One. 2015 Aug 5;10(8):e0134882. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 395.9±42.0 °C at 760 mmHg Molecular Formula C18H18F3N3O Molecular Weight 349.350 Flash Point 193.3±27.9 °C Exact Mass 349.140198 PSA 45.23000 LogP 4.15 Appearance of Characters light yellow solid Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.578 InChIKey DWFGGOFPIISJIT-UHFFFAOYSA-N SMILES O=C(Nc1cc(C(F)(F)F)ccc1N1CCCCC1)c1ccncc1 Storage condition -20℃ |
| Use of | SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1. Properties Name N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide Synonym More Synonyms SRPIN340 Biological Activity Description SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> SRPK Research Areas >> Cancer Ki: 0.89 μM (SRPK1)[1] In Vitro SRPIN340 is a serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1. SRPIN340 also inhibits SRPK2, but shows no significant inhibition on other SRPK, such as Clk1 and Clk4. SRPIN340 promotes degradation of SRp75, which is necessary for HIV expression. SRPIN340 suppresses the propagation of Sindbis virus (IC50, 60 μM) as well as severe acute respiratory syndrome virus[1]. SRPIN340 shows inhibitory effect on leukemia cell lines, such as AML HL60, ALL-T Molt4 and Jurkat, with IC50s of 44.7 μM, 92.2 μM and 82.3 μM, respectively[2]. References [1]. Fukuhara T, et al. Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11329-33. [2]. Siqueira RP, et al. Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340). PLoS One. 2015 Aug 5;10(8):e0134882. Chemical & Physical Properties Molecular Formula C18H18F3N3O Exact Mass 349.140198 PSA 45.23000 Appearance of Characters light yellow solid Index of Refraction 1.578 InChIKey DWFGGOFPIISJIT-UHFFFAOYSA-N Storage condition -20℃ |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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