CAS Number1649-18-9
Synonyms1-[3-(4-Fluorobenzoyl)propyl]-4-(2-pyridyl)piperazine; Suicalm; 4'-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone; 1-(4-fluoro-phenyl)-4-(4-pyridin-2-yl-piperazin-1-yl)-butan-1-one; Stresnil; Azaperon; 1-(4-Fluorophenyl)-4-(4-(2-pyridinyl)-1-piperazinyl)-1-butanone; Azaperone; Eucalmyl; 1-(4-Fluorophenyl)-4-(4-(pyridin-2-yl)piperazin-1-yl)butan-1-one; Sedaperone vet; 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone; 1-(4-fluorophenyl)-4-[4-(pyridin-2-yl)piperazin-1-yl]butan-1-one; Fluoperidol; 1-<3-(4-Fluorbenzoyl)propyl>-4-(2-pyridyl)piperazin; EINECS 216-715-8; MFCD00866692; R-1929; {4'-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone}; Azeperone; Azaperone (USP)
Molecular FormulaC19H22FN3O
Molecular Weight327.40
Purity99%
Density1.2±0.1 g/cm3
Boiling Point499.5±45.0 °C at 760 mmHg
Melting Point92-95ºC
AppearanceWhite or off-white crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1649-18-9 |
| Catalog No. | 2A-9009273 |
| Chinese Name | 阿扎哌隆 |
| Synonyms | 1-[3-(4-Fluorobenzoyl)propyl]-4-(2-pyridyl)piperazine; Suicalm; 4'-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone; 1-(4-fluoro-phenyl)-4-(4-pyridin-2-yl-piperazin-1-yl)-butan-1-one; Stresnil; Azaperon; 1-(4-Fluorophenyl)-4-(4-(2-pyridinyl)-1-piperazinyl)-1-butanone; Azaperone; Eucalmyl; 1-(4-Fluorophenyl)-4-(4-(pyridin-2-yl)piperazin-1-yl)butan-1-one; Sedaperone vet; 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone; 1-(4-fluorophenyl)-4-[4-(pyridin-2-yl)piperazin-1-yl]butan-1-one; Fluoperidol; 1-<3-(4-Fluorbenzoyl)propyl>-4-(2-pyridyl)piperazin; EINECS 216-715-8; MFCD00866692; R-1929; {4'-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone}; Azeperone; Azaperone (USP) |
| Molecular Formula | C19H22FN3O |
| Molecular Weight | 327.40 |
| Purity | 99 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 499.5±45.0 °C at 760 mmHg |
| Melting Point | 92-95ºC |
| Appearance | White or off-white crystal |
| Storage Condition | 0-6°C |
| Application | Azaperone (R-1929) is a dopamine antagonist with some antihistamine and anticholinergic properties, and has sedative and antiemetic effects. |
| HTC | 2942000000 |
| PubChem ID | 329749087 |
| MDL Number | MFCD00866692 |
| SMILES | Fc1ccc(cc1)C(=O)CCCN2CCN(CC2)c3ccccn3 |
| InChI | 1S/C19H22FN3O/c20-17-8-6-16(7-9-17)18(24)4-3-11-22-12-14-23(15-13-22)19-5-1-2-10-21-19/h1-2,5-10H,3-4,11-15H2 |
| InChI Key | XTKDAFGWCDAMPY-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/9273_1_1649_18_9.pdf |
| Use of | Azaperone (R-1929) acts as a dopamine antagonist but also has some antihistaminic and anticholinergic properties. Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. Properties Articles33 Name 1-(4-fluorophenyl)-4-(4-pyridin-2-ylpiperazin-1-yl)butan-1-one Synonym More Synonyms Azaperone Biological Activity Description Azaperone (R-1929) acts as a dopamine antagonist but also has some antihistaminic and anticholinergic properties. Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Chemical & Physical Properties Molecular Formula C19H22FN3O Exact Mass 327.174683 PSA 36.44000 Index of Refraction 1.568 Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Butyrophenone, 4'-fluoro-4-(4-(2-pyridyl)-1-piperazinyl)- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C19-H22-F-N3-O MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T6N DNTJ D3VR DF& A- BT6NJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - tremor REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1798,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - tremor REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1798,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,185,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - tremor REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1798,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - rigidity (including catalepsy) REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 35,605,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,185,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - tremor REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1798,1974 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Gastrointestinal - nausea or vomiting REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1798,1974 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Gastrointestinal - nausea or vomiting REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1798,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1798,1974 Safety Information Signal Word Danger Hazard Statements H301 Precautionary Statements Missing Phrase - N15.00950417 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves Hazard Codes Xn: Harmful; Risk Phrases R22 RTECS EU4550000 HS Code 2942000000 Synthetic Route Total: 1 Page 1-(2-Pyridinyl)... CAS#:34803-66-2 4-Chloro-p-fluo... CAS#:3874-54-2 CAS#:1649-18-9 Literature: Jaen; Caprathe; Pugsley; Wise; Akunne Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3929 - 3936 Precursor & DownStream Precursor 2 CAS#:34803-66-2 1-(2-Pyridinyl)... CAS#:3874-54-2 4-Chloro-p-fluo... DownStream 1 CAS#:2804-05-9 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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