CAS Number51-40-1
SynonymsNorepinephrine Bitartrate; l-noradrenalinetartrate; noradrenaline bitartrate; Levarterenolbitartrate; MFCD00036384; 4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol 2,3-dihydroxysuccinate (1:1); Leverterenol bitartrate; noradrenalinetartrate; 4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol 2,3-dihydroxysuccinate (1:1); 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, 2,3-dihydroxybutanedioate (1:1) (salt); L-ARTERENOL BITARTRATE; Noradrenalineacidtartrate; 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol 2,3-dihydroxybutanedioate (1:1); NORADRENALINE; EINECS 200-095-0; Levoarterenol bitartrate
Molecular FormulaC12H17NO9
Molecular Weight337.28
Boiling Point442.6ºC at 760 mmHg
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 51-40-1 |
| Catalog No. | 2A-9091941 |
| Chinese Name | L-去甲肾上腺素酒石酸氢盐 |
| Synonyms | Norepinephrine Bitartrate; l-noradrenalinetartrate; noradrenaline bitartrate; Levarterenolbitartrate; MFCD00036384; 4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol 2,3-dihydroxysuccinate (1:1); Leverterenol bitartrate; noradrenalinetartrate; 4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol 2,3-dihydroxysuccinate (1:1); 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, 2,3-dihydroxybutanedioate (1:1) (salt); L-ARTERENOL BITARTRATE; Noradrenalineacidtartrate; 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol 2,3-dihydroxybutanedioate (1:1); NORADRENALINE; EINECS 200-095-0; Levoarterenol bitartrate |
| Molecular Formula | C12H17NO9 |
| Molecular Weight | 337.28 |
| Boiling Point | 442.6ºC at 760 mmHg |
| Appearance | solid |
| Storage Condition | room temperature |
| Packaging | III |
| Application | Norepinephrine tartrate (Levarterenol tartrate) is a natural stress hormone and neurotransmitter. It is a β1-selective adrenergic receptor agonist with an EC50 value of 5.37 μM. |
| HTC | 2922210000 |
| PubChem ID | 56451796 |
| MDL Number | MFCD00150449 |
| SMILES | O.O[C@H]([C@@H](O)C(O)=O)C(O)=O.NC[C@H](O)c1ccc(O)c(O)c1 |
| InChI | 1S/C8H11NO3.C4H6O6.H2O/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10;/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10);1H2/t8-;1-,2-;/m01./s1 |
| InChI Key | LNBCGLZYLJMGKP-LUDZCAPTSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 12352106 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/91941_1_51_40_1.pdf |
| Use of | Norepinephrine tartrate (Levarterenol tartrate), a naturally occurring chemical in the body that acts as both a stress hormone and neurotransmitter, is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM. Properties Name l-Noradrenaline tartrate Synonym More Synonyms Noradrenaline tartrate Biological Activity Description Norepinephrine tartrate (Levarterenol tartrate), a naturally occurring chemical in the body that acts as both a stress hormone and neurotransmitter, is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM. Related Catalog Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor EC50: 5.37 μM (β1-selective adrenergic receptor)[1]. In Vitro Norepinephrine (NE) bitartrate monohydrate is generally considered to be a β1-subtype selective adrenergic agonist. Norepinephrine (NE) also has direct activity at the β2-adrenoceptor in higher concentrations[1]. Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment[2]. Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[2]. RT-PCR[2] Cell Line: Subcutaneous preadipocytes Adipocytes. Concentration: 10 μM. Incubation Time: 6 hours. Result: AT2 activation suppressed Norepinephrine induced UCP1 in white adipocytes (iWA) References [1]. MacGregor DA, et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200. [2]. Littlejohn NK, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-60. Chemical & Physical Properties Molecular Formula C12H17NO9 Exact Mass 319.090332 PSA 201.77000 InChIKey WNPNNLQNNJQYFA-YIDNRZKSSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : Z1YQR CQ DQ &OVYQYQVO HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3987 ug/kg TOXIC EFFECTS : Behavioral - excitement TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 26800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1025 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes MUTATION DATA TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11,523,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5302 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 314 (estimated) Safety Information Hazard Codes T+ RIDADR UN 3249 Packaging Group III Hazard Class 6.1(b) HS Code 2922210000 |
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