CAS Number51146-57-7
SynonymsInoven; Lebrufen; (RS)-ibuprofen; Ibumetin; Femadon; 2-(4-Isobutylphenyl)propionic acid; QVY1&R D1Y1&1; l-Ibuprofen; Para-Isobutylhydratropic Acid; Ibuprofen; (2R)-2-(4-Isobutylphenyl)propanoic acid; (R)-2-(4-Isobutylphenyl)propanoic acid; (±)-ibuprofen; Novogent N; Ibutid; fenbid; 2-(4-Isobutylphenyl)propanoic acid; MOTRIN; Dolgirid; (R)-Ibuprofen; Amibufen; (-)-ibuprofen; Nurofen; (R)-(-)-Ibuprofen; Racemic ibuprofen; (2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid; Advil; Brufen; Dolo-Dolgit; Seclodin
Molecular FormulaC13H18O2
Molecular Weight206.281
Purity98%%
Density1.0±0.1 g/cm3
Boiling Point319.6±11.0 °C at 760 mmHg
Melting Point41-42ºC
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 51146-57-7 |
| Catalog No. | 2A-9091544 |
| Chinese Name | (R)-布洛芬 |
| Synonyms | Inoven; Lebrufen; (RS)-ibuprofen; Ibumetin; Femadon; 2-(4-Isobutylphenyl)propionic acid; QVY1&R D1Y1&1; l-Ibuprofen; Para-Isobutylhydratropic Acid; Ibuprofen; (2R)-2-(4-Isobutylphenyl)propanoic acid; (R)-2-(4-Isobutylphenyl)propanoic acid; (±)-ibuprofen; Novogent N; Ibutid; fenbid; 2-(4-Isobutylphenyl)propanoic acid; MOTRIN; Dolgirid; (R)-Ibuprofen; Amibufen; (-)-ibuprofen; Nurofen; (R)-(-)-Ibuprofen; Racemic ibuprofen; (2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid; Advil; Brufen; Dolo-Dolgit; Seclodin |
| Molecular Formula | C13H18O2 |
| Molecular Weight | 206.281 |
| Purity | 98% |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 319.6±11.0 °C at 760 mmHg |
| Melting Point | 41-42ºC |
| Appearance | solid |
| Storage Condition | room temperature |
| Application | (R)-(-)-Ibuprofen is the R-isomer of Ibuprofen, which has no effect on COX and can inhibit the activation of NF-κB; (R)-(-)-Ibuprofen has anti-inflammatory and analgesic effects. |
| HTC | 2916399090 |
| PubChem ID | 841635 |
| SMILES | CC(C)Cc1ccc(C(C)C(=O)O)cc1 |
| InChI | InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m1/s1 |
| InChI Key | HEFNNWSXXWATRW-SNVBAGLBSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/91544_1_51146_57_7.pdf |
| Bioactivity | (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects. Related Catalog Research Areas >> Inflammation/Immunology Target NF-κB In Vitro (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, with no inhibitory effect on COX, but is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids[1]. (R)-(-)-Ibuprofen (1 μM) significantly reduces NF-κB activation and completely prevents NF-κB induction at 10 μM. (R)-(-)-Ibuprofen inhibits NF-κB luciferase activity with an IC50 of 121.8 μM, weaker than that of S(+)-ibuprofen (IC50, 61.7 μM). Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF[2]. References [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [2]. Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123(4):645-52. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 319.6±11.0 °C at 760 mmHg Melting Point 41-42ºC Molecular Formula C13H18O2 Molecular Weight 206.281 Flash Point 216.7±14.4 °C Exact Mass 206.130676 PSA 37.30000 LogP 3.72 Vapour Pressure 0.0±0.7 mmHg at 25°C Index of Refraction 1.519 InChIKey HEFNNWSXXWATRW-SNVBAGLBSA-N SMILES CC(C)Cc1ccc(C(C)C(=O)O)cc1 |
| Use of | (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects. Properties Name levibuprofen Synonym More Synonyms (R)-(-)-Ibuprofen Biological Activity Description (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects. Related Catalog Research Areas >> Inflammation/Immunology References [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [2]. Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123(4):645-52. Chemical & Physical Properties Molecular Formula C13H18O2 Exact Mass 206.130676 PSA 37.30000 Index of Refraction 1.519 InChIKey HEFNNWSXXWATRW-SNVBAGLBSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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