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TRIPROLIDINE HCL

Name: TRIPROLIDINE HCL
Brand: 2A Biotech
SKU: 2A-9091493

CAS Number550-70-9

SynonymsEINECS 208-985-0; MFCD00039044; Triprolidine Hydrochloride; Triprolidine HCl

Molecular FormulaC19H23ClN2

Molecular Weight314.85200

Purity98%

Density1.061g/cm3

Boiling Point435.4ºC at 760mmHg

Melting Point59-61ºC

MSDSChinese English

Symbol

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Cat. No.: 2A-9091493 Purity: 98%

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Quality Control of [ 550-70-9 ] Purity: 98% SDS Specification MoL

Chemical & Physical Properties
CAS Number	550-70-9
Catalog No.	2A-9091493
Chinese Name	2-(1-(4-甲基苯基)-3-(1-吡咯烷基)-1-丙烯基)吡啶盐酸盐
Synonyms	EINECS 208-985-0; MFCD00039044; Triprolidine Hydrochloride; Triprolidine HCl
Molecular Formula	C19H23ClN2
Molecular Weight	314.85200
Purity	98
Density	1.061g/cm3
Boiling Point	435.4ºC at 760mmHg
Melting Point	59-61ºC
Storage Condition	2-8°C
Packaging	III
Application	Triprolidine is an orally active, first-generation histamine H1-receptor antagonist that can be used in the study of allergic rhinitis. In rats, triprolidine blocks movement and sensation in the spina
HTC	2933990090
PubChem ID	8149574
SMILES	Cc1ccc(C(=CCN2CCCC2)c2ccccn2)cc1.Cl
InChI	InChI=1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;
InChI Key	WYUYEJNGHIOFOC-UHFFFAOYSA-N
Hazard Symbols	6.1(b)
Use of	Triprolidine is an oral active, first-generation histamine H1-receptor antagonist. Triprolidine can be used for the research of allergic rhinitis. triprolidine exhibits spinal motor and sensory block in rats[1][2][3]. Properties Name triprolidine hydrochloride (anh.) Synonym More Synonyms Triprolidine hydrochloride Biological Activity Description Triprolidine is an oral active, first-generation histamine H1-receptor antagonist. Triprolidine can be used for the research of allergic rhinitis. triprolidine exhibits spinal motor and sensory block in rats[1][2][3]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor H1 Receptor References [1]. K J Simons, et al. An investigation of the H1-receptor antagonist triprolidine: pharmacokinetics and antihistaminic effects. J Allergy Clin Immunol. 1986 Feb;77(2):326-30. [2]. D L Deal, et al. Disposition and metabolism of triprolidine in mice. Drug Metab Dispos. Nov-Dec 1992;20(6):920-7. [3]. Jann-Inn Tzeng, et al. Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats. J Pharm Pharmacol. 2018 Dec;70(12):1654-1661. Chemical & Physical Properties Exact Mass 314.15500 PSA 16.13000 LogP 4.65740 InChIKey WYUYEJNGHIOFOC-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, monohydrochloride, (E)- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T6NJ BYR D1&2- AT5NTJ &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,375,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,525,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,525,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 8,171,1953 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Behavioral - tremor Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 8,171,1953 * NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA * NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81570 No. of Facilities: 842 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 990 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81570 No. of Facilities: 178 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 2378 (estimated) No. of Female Employees: 1467 (estimated) Safety Information Hazard Codes Xn Safety Phrases 26-36 RIDADR UN 3249 WGK Germany 3 RTECS UT7658000 Packaging Group III Hazard Class 6.1(b) HS Code 2933990090 Synthetic Route Total: 1 Page triprolidine CAS#:486-12-4 Triprolidine hy... CAS#:550-70-9 2-[(Z)-1-(4-met... CAS#:13573-69-8 Triprolidine hy... CAS#:550-70-9 Precursor & DownStream Precursor 1 CAS#:486-12-4 triprolidine DownStream 0
Tax Rebate	13.0%
Supervision	None. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport Info	Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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TRIPROLIDINE HCL

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