CAS Number41294-56-8
SynonymsEINECS 255-297-1; Bondiol; Alfarol; Alpharol; Oxydevit; Un Alfa; Etalpha; One-α; (1a,3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3-diol; 1a-Hydroxyvitamin D3; Alfacalcidiol; 1α-Hydroxycholecalciferol; 1a-Hydroxycholecalciferol; 1a-OH-CC; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β-diol; unalpha; MFCD04001508; (1S,3R,5Z,7E)-9,10-Secocholesta-5,7,10-triene-1,3-diol; 1α-Hydroxyvitamin D3; Alfacalcidol; 1-hydroxycholecalciferol
Molecular FormulaC27H44O2
Molecular Weight400.64
Purity98%
Density1.0±0.1 g/cm3
Boiling Point531.5±50.0 °C at 760 mmHg
Melting Point134-136°C
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 41294-56-8 |
| Catalog No. | 2A-9009097 |
| Chinese Name | 阿法骨化醇 |
| Synonyms | EINECS 255-297-1; Bondiol; Alfarol; Alpharol; Oxydevit; Un Alfa; Etalpha; One-α; (1a,3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3-diol; 1a-Hydroxyvitamin D3; Alfacalcidiol; 1α-Hydroxycholecalciferol; 1a-Hydroxycholecalciferol; 1a-OH-CC; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β-diol; unalpha; MFCD04001508; (1S,3R,5Z,7E)-9,10-Secocholesta-5,7,10-triene-1,3-diol; 1α-Hydroxyvitamin D3; Alfacalcidol; 1-hydroxycholecalciferol |
| Molecular Formula | C27H44O2 |
| Molecular Weight | 400.64 |
| Purity | 98 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 531.5±50.0 °C at 760 mmHg |
| Melting Point | 134-136°C |
| Appearance | solid |
| Storage Condition | Sealed, cool, dry storage |
| Packaging | I |
| Application | Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator. |
| HTC | 29361000 |
| PubChem ID | 329770599 |
| MDL Number | MFCD00868328 |
| SMILES | CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C |
| InChI | 1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1 |
| InChI Key | OFHCOWSQAMBJIW-AVJTYSNKSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(a) |
| MSDS | msds/9097_1_41294_56_8.pdf |
| Bioactivity | Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication. IC50 value: Target: VDR activatorAlfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) improves mechanical bone strength and bone mass; suppresses osteoclastic bone resorption in vivo. Related Catalog Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Metabolic Disease References [1]. Shiraishi et al (2000) Alfacalcidol inhibits bone resorption and stmulates formation in an ovariectomized rat model of osteoporosis: Distinct actions from estrogen. Journal of Bone and Mineral Research. 15 770. [2]. Ringe JD, Schacht E. et al. Prevention and therapy of osteoporosis: the roles of plain vitamin D and alfacalcidol. Rheumatol Int. 2004 Jul;24(4):189-97. [3]. Ivarsen P, Povlsen JV, Christensen KL.Effect of alfacalcidol on cardiac function in patients with chronic kidney disease stage 4 and secondary hyperparathyroidism: A pilot study.Scand J Urol Nephrol. 2012 Jun 25. [4]. Rianthavorn P,et al. Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone.J Pediatr Endocrinol Metab. 2012;25(3-4):307-12. [5]. Ringe JD, Farahmand P, Schacht E.Alfacalcidol in men with osteoporosis: a prospective, observational, 2-year trial on 214 patients.Rheumatol Int. 2012 Apr 8. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 531.5±50.0 °C at 760 mmHg Melting Point 134-136°C Molecular Formula C27H44O2 Molecular Weight 400.637 Flash Point 222.6±24.7 °C Exact Mass 400.334137 PSA 40.46000 LogP 8.31 Vapour Pressure 0.0±3.2 mmHg at 25°C Index of Refraction 1.534 InChIKey OFHCOWSQAMBJIW-BCDWVSPMSA-N SMILES C=C1C(=CC=C2CCCC3(C)C2CCC3C(C)CCCC(C)C)CC(O)CC1O Storage condition −20°C |
| Use of | Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication. IC50 value: Target: VDR activatorAlfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) improves mechanical bone strength and bone mass; suppresses osteoclastic bone resorption in vivo. Properties Articles27 Name alfacalcidol Synonym More Synonyms Alfacalcidol Biological Activity Description Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication. IC50 value: Target: VDR activatorAlfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) improves mechanical bone strength and bone mass; suppresses osteoclastic bone resorption in vivo. Related Catalog Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Metabolic Disease References [1]. Shiraishi et al (2000) Alfacalcidol inhibits bone resorption and stmulates formation in an ovariectomized rat model of osteoporosis: Distinct actions from estrogen. Journal of Bone and Mineral Research. 15 770. [2]. Ringe JD, Schacht E. et al. Prevention and therapy of osteoporosis: the roles of plain vitamin D and alfacalcidol. Rheumatol Int. 2004 Jul;24(4):189-97. [3]. Ivarsen P, Povlsen JV, Christensen KL.Effect of alfacalcidol on cardiac function in patients with chronic kidney disease stage 4 and secondary hyperparathyroidism: A pilot study.Scand J Urol Nephrol. 2012 Jun 25. [4]. Rianthavorn P,et al. Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone.J Pediatr Endocrinol Metab. 2012;25(3-4):307-12. [5]. Ringe JD, Farahmand P, Schacht E.Alfacalcidol in men with osteoporosis: a prospective, observational, 2-year trial on 214 patients.Rheumatol Int. 2012 Apr 8. Chemical & Physical Properties Molecular Formula C27H44O2 Exact Mass 400.334137 PSA 40.46000 Index of Refraction 1.534 InChIKey OFHCOWSQAMBJIW-BCDWVSPMSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Alfacalcidol) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (Alfacalcidol) IFRS: Toxic solid, organic, n.o.s. (Alfacalcidol) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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