CAS Number52-39-1
Synonyms11β,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al; (11β)-11,21-dihydroxy-3,20-dioxo-Pregn-4-en-18-al; Aldocorten; Aldocortene; (11b)-11,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al; 11-β,21-Dihydroxy-3,20-dioxopregn-4-en-18-al; Aldocortin; MFCD00051136; Aldosterone; (11β)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al; d-Aldosterone; 18-Oxocorticosterone; (11b)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al; 18-Formyl-11b,21-dihydroxy-4-pregnene-3,20-dione; 11b,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al; 11β,21-Dihydroxypregn-4-ene-3,18,20-trione; Reichstein X; Elektrocortin; 4-pregnen-11,21-diol-3,20-dione-18-al; EINECS 200-139-9; Electrocortin
Molecular FormulaC21H28O5
Molecular Weight360.44
Purity≥95 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point568.1±50.0 °C at 760 mmHg
Melting Point170-172ºC
Appearancepowder
EINECS200-139-9
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 52-39-1 |
| Catalog No. | 2A-0202151 |
| Chinese Name | 醛固酮 |
| Synonyms | 11β,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al; (11β)-11,21-dihydroxy-3,20-dioxo-Pregn-4-en-18-al; Aldocorten; Aldocortene; (11b)-11,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al; 11-β,21-Dihydroxy-3,20-dioxopregn-4-en-18-al; Aldocortin; MFCD00051136; Aldosterone; (11β)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al; d-Aldosterone; 18-Oxocorticosterone; (11b)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al; 18-Formyl-11b,21-dihydroxy-4-pregnene-3,20-dione; 11b,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al; 11β,21-Dihydroxypregn-4-ene-3,18,20-trione; Reichstein X; Elektrocortin; 4-pregnen-11,21-diol-3,20-dione-18-al; EINECS 200-139-9; Electrocortin |
| Molecular Formula | C21H28O5 |
| Molecular Weight | 360.44 |
| Purity | ≥95 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 568.1±50.0 °C at 760 mmHg |
| Melting Point | 170-172ºC |
| Appearance | powder |
| Storage Condition | Store sealed at 0-4ºC. |
| Application | Aldosterone is a primary mineralocorticoid. Aldosterone is a steroid hormone synthesized and secreted by the glomerular zone (ZG) of the adrenal cortex in response to activation of the renin-angiotens |
| EINECS | 200-139-9 |
| HTC | 29372900 |
| PubChem ID | 24891458 |
| MDL Number | MFCD00051136 |
| SMILES | C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@]4(C[C@H](O)[C@H]23)C=O |
| InChI | 1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1 |
| InChI Key | PQSUYGKTWSAVDQ-ZVIOFETBSA-N |
| Beilstein/REAXYS | 3224996 |
| NACRES Code | NA.77 |
| UNSPSC | 51111800 |
| Hazard Symbols | Transport |
| MSDS | msds/9095_1_52_39_1.pdf |
| Bioactivity | Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Target Human Endogenous Metabolite In Vitro Aldosterone (1-1000 nM; 24 hours) inhibits interleukin-1β-stimulated nitrite production by vascular smooth muscle cells in a dose-dependent manner[3]. In Vivo Aldosterone (1 mg/Kg+1% NaCl; i.h.; once daily for 3 weeks) significantly increases systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP)[4]. Aldosterone (0.72 mg/kg/day; 14 days) causes a small increase ( 14 mmHg) in blood pressure in male mice[5]. Animal Model: Forty male Wistar rats[4] Dosage: 1 mg/Kg (+1% NaCl) Administration: i.h.; once daily for 3 weeks Result: Systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) were significantly higher in aldosterone-salt-treated animals. References [1]. Nanba K, et al. Aging and Adrenal Aldosterone Production. Hypertension. 2018 Feb;71(2):218-223. [2]. Cannavo A, et al. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxid Med Cell Longev. 2018 Sep 19;2018:1204598. [3]. Ikeda U, et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995 Jul 18;290(2):69-73. [4]. Martín-Fernández B, et al. Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in ratheart through mineralocorticoid receptor blockade. PLoS One. 2014 Oct 29;9(10):e111104. [5]. Dinh QN, et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res. 2016 Apr 15;1637:146-153. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 568.1±50.0 °C at 760 mmHg Melting Point 170-172ºC Molecular Formula C21H28O5 Molecular Weight 360.444 Flash Point 311.4±26.6 °C Exact Mass 360.193665 PSA 91.67000 LogP 0.73 Vapour Pressure 0.0±3.5 mmHg at 25°C Index of Refraction 1.586 InChIKey PQSUYGKTWSAVDQ-ZVIOFETBSA-N SMILES CC12CCC(=O)C=C1CCC1C2C(O)CC2(C=O)C(C(=O)CO)CCC12 |
| Use of | Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2]. Properties Articles284 Name aldosterone Synonym More Synonyms aldosterone Biological Activity Description Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Human Endogenous Metabolite In Vitro Aldosterone (1-1000 nM; 24 hours) inhibits interleukin-1β-stimulated nitrite production by vascular smooth muscle cells in a dose-dependent manner[3]. References [1]. Nanba K, et al. Aging and Adrenal Aldosterone Production. Hypertension. 2018 Feb;71(2):218-223. [2]. Cannavo A, et al. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxid Med Cell Longev. 2018 Sep 19;2018:1204598. [3]. Ikeda U, et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995 Jul 18;290(2):69-73. [4]. Martín-Fernández B, et al. Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in ratheart through mineralocorticoid receptor blockade. PLoS One. 2014 Oct 29;9(10):e111104. [5]. Dinh QN, et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res. 2016 Apr 15;1637:146-153. Chemical & Physical Properties Molecular Formula C21H28O5 Exact Mass 360.193665 PSA 91.67000 Index of Refraction 1.586 InChIKey PQSUYGKTWSAVDQ-ZVIOFETBSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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