CAS Number53164-05-9
Synonyms({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)acetic acid; 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, carboxymethyl ester; Solart; 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic Acid Carboxymethyl Ester; Acemetacinum; Tilur; [1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetoxyacetic Acid; glycolic acid ester of indomethacin; 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid carboxymethyl ester; Reudol; Rheutrop; TVX-1322; BAY f4975; Acemetacin (JAN); acemetacin; Azeat; Acemix; aximeixin; {2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}acetic acid; Acephlogont; [({1-[(4-chlorophenyl)carbonyl]-2-methyl-5-(methyloxy)-1H-indol-3-yl}acetyl)oxy]acetic acid; k-708; rheumibis; Rantudil; tv1322; Gamespir; [({1-[(4-chl
Molecular FormulaC21H18ClNO6
Molecular Weight415.82
Purity98%
Density1.4±0.1 g/cm3
Boiling Point565.5±50.0 °C at 760 mmHg
Melting Point151.5°C
AppearanceLight yellow fine crystals are obtained from petroleum ether, with a melting point of 150-153°C. Acu
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 53164-05-9 |
| Catalog No. | 2A-9009035 |
| Chinese Name | 阿西美辛 |
| Synonyms | ({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)acetic acid; 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, carboxymethyl ester; Solart; 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic Acid Carboxymethyl Ester; Acemetacinum; Tilur; [1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetoxyacetic Acid; glycolic acid ester of indomethacin; 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid carboxymethyl ester; Reudol; Rheutrop; TVX-1322; BAY f4975; Acemetacin (JAN); acemetacin; Azeat; Acemix; aximeixin; {2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}acetic acid; Acephlogont; [({1-[(4-chlorophenyl)carbonyl]-2-methyl-5-(methyloxy)-1H-indol-3-yl}acetyl)oxy]acetic acid; k-708; rheumibis; Rantudil; tv1322; Gamespir; [({1-[(4-chl |
| Molecular Formula | C21H18ClNO6 |
| Molecular Weight | 415.82 |
| Purity | 98 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 565.5±50.0 °C at 760 mmHg |
| Melting Point | 151.5°C |
| Appearance | Light yellow fine crystals are obtained from petroleum ether, with a melting point of 150-153°C. Acu |
| Storage Condition | -20°C Freezer |
| Packaging | II |
| Application | Acemetacin is a non-steroidal anti-inflammatory compound. |
| HTC | 2942000000 |
| PubChem ID | 329831163 |
| MDL Number | MFCD00151473 |
| SMILES | COc1ccc2n(c(C)c(CC(=O)OCC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3 |
| InChI | 1S/C21H18ClNO6/c1-12-16(10-20(26)29-11-19(24)25)17-9-15(28-2)7-8-18(17)23(12)21(27)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25) |
| InChI Key | FSQKKOOTNAMONP-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(a) |
| MSDS | msds/9035_1_53164_05_9.pdf |
| Bioactivity | Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.Target: COXAcemetacin is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. Acemetacin, a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. An advantage of acemetacin is that it reduces gastric damage when compared to indometacin. From Wikipedia. Related Catalog Research Areas >> Inflammation/Immunology Target COX-1:85 μM (IC50, in human intact cell) References [1]. Tavares IA, et al. Non-steroidal anti-inflammatory drugs that cause relatively little gastric damage. J Gastroenterol Hepatol. 1998 Nov;13(S3):S190-S192. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 565.5±50.0 °C at 760 mmHg Melting Point 151.5°C Molecular Formula C21H18ClNO6 Molecular Weight 415.824 Flash Point 295.8±30.1 °C Exact Mass 415.082275 PSA 94.83000 LogP 3.20 Vapour Pressure 0.0±1.6 mmHg at 25°C Index of Refraction 1.611 InChIKey FSQKKOOTNAMONP-UHFFFAOYSA-N SMILES COc1ccc2c(c1)c(CC(=O)OCC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1 Storage condition -20°C Freezer |
| Use of | Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.Target: COXAcemetacin is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. Acemetacin, a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. An advantage of acemetacin is that it reduces gastric damage when compared to indometacin. From Wikipedia. Properties Articles26 Name acemetacin Synonym More Synonyms acemetacin Biological Activity Description Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.Target: COXAcemetacin is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. Acemetacin, a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. An advantage of acemetacin is that it reduces gastric damage when compared to indometacin. From Wikipedia. Related Catalog Research Areas >> Inflammation/Immunology COX-1:85 μM (IC50, in human intact cell) References [1]. Tavares IA, et al. Non-steroidal anti-inflammatory drugs that cause relatively little gastric damage. J Gastroenterol Hepatol. 1998 Nov;13(S3):S190-S192. Chemical & Physical Properties Exact Mass 415.082275 PSA 94.83000 Index of Refraction 1.611 InChIKey FSQKKOOTNAMONP-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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