CAS Number54-25-1
Synonyms6-azur; AZURIDINE; ribo-azuracil; 6-azuridine; 6-AZAURIDINE; 6-aza-uridine; 6-Azauracil Ribozide; MFCD00006472; 2-(β-D-Ribofuranosyl)-1,2,4-triazine-3,5(2H,4H)-dione; 6-phosphonouridine 5′-monophosphate; azauridine; azur; EINECS 200-199-6; ribo-Azauracil; 2-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2H--[1,2,4]triazine-3,5-dione; 2-b-D-Ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione
Molecular FormulaC8H11N3O6
Molecular Weight245.19
Purity≥99 (TLC)%
Density2.1±0.1 g/cm3
Melting Point157-159 °C (lit.)
Appearancepowder
EINECS200-199-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 54-25-1 |
| Catalog No. | 2A-9009006 |
| Chinese Name | 6-氮杂尿苷 |
| Synonyms | 6-azur; AZURIDINE; ribo-azuracil; 6-azuridine; 6-AZAURIDINE; 6-aza-uridine; 6-Azauracil Ribozide; MFCD00006472; 2-(β-D-Ribofuranosyl)-1,2,4-triazine-3,5(2H,4H)-dione; 6-phosphonouridine 5′-monophosphate; azauridine; azur; EINECS 200-199-6; ribo-Azauracil; 2-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2H--[1,2,4]triazine-3,5-dione; 2-b-D-Ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione |
| Molecular Formula | C8H11N3O6 |
| Molecular Weight | 245.19 |
| Purity | ≥99 (TLC) |
| Density | 2.1±0.1 g/cm3 |
| Melting Point | 157-159 °C (lit.) |
| Appearance | powder |
| Storage Condition | Store dry at 4℃. |
| Application | 6-Azuridine is a purine nucleoside analog. Purine nucleoside analogues have broad antitumor activity and target indolent lymphoid malignancies. The anti-cancer mechanism in this process relies on inhi |
| EINECS | 200-199-6 |
| PubChem ID | 24890597 |
| MDL Number | MFCD00006472 |
| SMILES | OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2N=CC(=O)NC2=O |
| InChI | 1S/C8H11N3O6/c12-2-3-5(14)6(15)7(17-3)11-8(16)10-4(13)1-9-11/h1,3,5-7,12,14-15H,2H2,(H,10,13,16)/t3-,5-,6-,7-/m1/s1 |
| InChI Key | WYXSYVWAUAUWLD-SHUUEZRQSA-N |
| NACRES Code | NA.51 |
| UNSPSC | 41106305 |
| Hazard Symbols | Transport |
| MSDS | msds/9006_1_54_25_1.pdf |
| Bioactivity | 6-Azuridine (6-Azauridine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others References [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. Chemical & Physical Properties Density 2.1±0.1 g/cm3 Melting Point 157-159 °C(lit.) Molecular Formula C8H11N3O6 Molecular Weight 245.19 Exact Mass 245.064789 PSA 137.67000 LogP -1.96 Index of Refraction 1.795 InChIKey WYXSYVWAUAUWLD-SHUUEZRQSA-N SMILES O=c1cnn(C2OC(CO)C(O)C2O)c(=O)[nH]1 Storage condition 2-8°C |
| Use of | 6-Azuridine (6-Azauridine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. Properties Articles32 Name 6-azauridine Synonym More Synonyms 6-AZAURIDINE Biological Activity Description 6-Azuridine (6-Azauridine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others References [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. Chemical & Physical Properties Molecular Formula C8H11N3O6 Exact Mass 245.064789 PSA 137.67000 LogP -1.96 Index of Refraction 1.795 InChIKey WYXSYVWAUAUWLD-SHUUEZRQSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip. |
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