CAS Number70-00-8
SynonymsViroptic; α,α,α-Trifluorothymidine; 2'-Deoxy-5-(trifluoromethyl)uridine; UNII-RMW9V5RW38; Trifluorothymidine; 1-(2-Deoxy-β-D-glycero-pentofuranosyl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione; Trifluridine; EINECS 200-722-8; 2'-Deoxy-5-trifluoromethyluridine; Virophta; a,a,a-Trifluorothymidine; MFCD00006534
Molecular FormulaC10H11F3N2O5
Molecular Weight296.20
Purity≥99 (HPLC)%
Density1.6±0.1 g/cm3
Melting Point190-193 °C (lit.)
Appearancepowder
EINECS200-722-8
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 70-00-8 |
| Catalog No. | 2A-9008872 |
| Chinese Name | 曲氟尿苷 |
| Synonyms | Viroptic; α,α,α-Trifluorothymidine; 2'-Deoxy-5-(trifluoromethyl)uridine; UNII-RMW9V5RW38; Trifluorothymidine; 1-(2-Deoxy-β-D-glycero-pentofuranosyl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione; Trifluridine; EINECS 200-722-8; 2'-Deoxy-5-trifluoromethyluridine; Virophta; a,a,a-Trifluorothymidine; MFCD00006534 |
| Molecular Formula | C10H11F3N2O5 |
| Molecular Weight | 296.20 |
| Purity | ≥99 (HPLC) |
| Density | 1.6±0.1 g/cm3 |
| Melting Point | 190-193 °C (lit.) |
| Appearance | powder |
| Water Solubility | Water solubility: soluble |
| Storage Condition | This product should be sealed and stored dry and b |
| Application | Trifluridine is an irreversible inhibitor of thymidylate synthase, thereby inhibiting DNA synthesis. Trifluridine is an antiviral drug used for herpes simplex virus (HSV) infections. |
| EINECS | 200-722-8 |
| PubChem ID | 24900027 |
| MDL Number | MFCD00006534 |
| SMILES | OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(C(=O)NC2=O)C(F)(F)F |
| InChI | 1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1 |
| InChI Key | VSQQQLOSPVPRAZ-RRKCRQDMSA-N |
| NACRES Code | NA.51 |
| UNSPSC | 41106305 |
| Hazard Symbols | Transport |
| Risk Codes | R20/21/22;R40 |
| Safety Description | S22;S36 |
| MSDS | msds/8872_1_70_00_8.pdf |
| Bioactivity | Trifluridine is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral drug for herpes simplex virus (HSV) infection. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Signaling Pathways >> Apoptosis >> Thymidylate Synthase Research Areas >> Cancer References [1]. Suzuki N, et al. Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. Int J Oncol. 2011 Jul;39(1):263-70. [2]. Suzuki N, et al. Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks. Exp Ther Med. 2011 May;2(3):393-397. [3]. Temmink OH, et al. Irinotecan-induced cytotoxicity to colon cancer cells in vitro is stimulated by pre-incubation withtrifluorothymidine. Eur J Cancer. 2007 Jan;43(1):175-83. [4]. Okayama T, et al. Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats. J Pharmacol Exp Ther. 2012 Feb;340(2):457-62. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Melting Point 190-193 °C(lit.) Molecular Formula C10H11F3N2O5 Molecular Weight 296.200 Exact Mass 296.062012 PSA 104.55000 LogP 0.07 Index of Refraction 1.534 InChIKey VSQQQLOSPVPRAZ-RRKCRQDMSA-N SMILES O=c1[nH]c(=O)n(C2CC(O)C(CO)O2)cc1C(F)(F)F Storage condition −20°C |
| Use of | Trifluridine is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral drug for herpes simplex virus (HSV) infection. Properties Name trifluridine Synonym More Synonyms Trifluorothymidine Biological Activity Description Trifluridine is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral drug for herpes simplex virus (HSV) infection. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Signaling Pathways >> Apoptosis >> Thymidylate Synthase Research Areas >> Cancer References [1]. Suzuki N, et al. Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. Int J Oncol. 2011 Jul;39(1):263-70. [2]. Suzuki N, et al. Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks. Exp Ther Med. 2011 May;2(3):393-397. [3]. Temmink OH, et al. Irinotecan-induced cytotoxicity to colon cancer cells in vitro is stimulated by pre-incubation withtrifluorothymidine. Eur J Cancer. 2007 Jan;43(1):175-83. [4]. Okayama T, et al. Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats. J Pharmacol Exp Ther. 2012 Feb;340(2):457-62. Chemical & Physical Properties Molecular Formula C10H11F3N2O5 Exact Mass 296.062012 PSA 104.55000 Index of Refraction 1.534 InChIKey VSQQQLOSPVPRAZ-RRKCRQDMSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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