CAS Number2642-98-0
SynonymsChrysen-6-ylamine; 6-Amino-chrysen; Chrysen-6-ylamin; 6-AMINOCHRYSENE; Chrysenex; Chrysen-6-amine; 6-Amc; Chrysonex; 6-chrysenylamine; 6-Chrysenamine; MFCD00003699; chrysene-6-ylamine; EINECS 220-149-7
Molecular FormulaC18H13N
Molecular Weight243.30
Purity95%
Density1.3±0.1 g/cm3
Boiling Point501.2±19.0 °C at 760 mmHg
Melting Point209-211 °C (lit.)
Appearancesolid
EINECS220-149-7
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2642-98-0 |
| Catalog No. | 2A-9086095 |
| Chinese Name | 7-胺基去乙酰氧基头胞烷酸 |
| Synonyms | Chrysen-6-ylamine; 6-Amino-chrysen; Chrysen-6-ylamin; 6-AMINOCHRYSENE; Chrysenex; Chrysen-6-amine; 6-Amc; Chrysonex; 6-chrysenylamine; 6-Chrysenamine; MFCD00003699; chrysene-6-ylamine; EINECS 220-149-7 |
| Molecular Formula | C18H13N |
| Molecular Weight | 243.30 |
| Purity | 95 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 501.2±19.0 °C at 760 mmHg |
| Melting Point | 209-211 °C (lit.) |
| Appearance | solid |
| Storage Condition | Store airtight in a cool, dry warehouse. |
| Application | 6-Aminochrysene (6-Aminochrysene) is an aromatic amine chemotherapeutic agent used for splenomegaly, myeloid leukemia and breast cancer. |
| EINECS | 220-149-7 |
| HTC | 2921499090 |
| PubChem ID | 24890902 |
| MDL Number | MFCD00003699 |
| SMILES | Nc1cc2c3ccccc3ccc2c4ccccc14 |
| InChI | 1S/C18H13N/c19-18-11-17-13-6-2-1-5-12(13)9-10-15(17)14-7-3-4-8-16(14)18/h1-11H,19H2 |
| InChI Key | KIVUHCNVDWYUNP-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| MSDS | msds/86095_1_2642_98_0.pdf |
| Bioactivity | 6-Aminochrysene (6-Aminochrysene) is an aromatic amine used as a chemotherapeutic agent in the treatment of splenomegaly, myeloid leukemia, and breast cancer. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer Research Areas >> Inflammation/Immunology In Vitro 6-Aminochrysene inhibits the hydroxylation of aniline, 0-demethylation of p-nitroanisole, and N-demethylation of aminopyrine by rat liver microsomes. Pre-treatment of rats with 6-aminochrysene markedly decreases the N-demethylation in vitro but significantly increases the hydroxylation and the 0-demethylation[1]. In Vivo 6-Aminochrysene is an inhibitor of the growth of several solid experimental tumours in vivo and has a cancerostatic effect on human breast cancer[1]. Long term topical skin application of 6-Aminochrysene to mice induces development of benign skin tumors after 3 months and of skin malignancies after 7 months. Female mice respond earlier than males. Induction of skin tumors is more rapid when 6-Aminochrysene is applied ventrally instead of dorsally. Urinary excretion is about twice as high after skin application than after oral administration[2]. Animal Admin Rats: Male CD rats are pre-treated with 25, 50 and 100 mg/kg of 6-Aminochrysene intraperitoneally once daily for 3 consecutive days before sacrifice, which is performed 24 h after the last administration. Controls receive only the solvent[1]. References [1]. Russo R, et al. Effects of 6-aminochrysene on liver microsomal enzyme activity. Xenobiotica. 1976 Apr;6(4):201-5. [2]. Lambelin G, et al. Carcinogenicity of 6-aminochrysene in mice. Eur J Cancer. 1975 May;11(5):327-34. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 501.2±19.0 °C at 760 mmHg Melting Point 209-211 °C(lit.) Molecular Formula C18H13N Molecular Weight 243.303 Flash Point 286.9±16.8 °C Exact Mass 243.104797 PSA 26.02000 LogP 4.63 Vapour Pressure 0.0±1.3 mmHg at 25°C Index of Refraction 1.814 InChIKey KIVUHCNVDWYUNP-UHFFFAOYSA-N SMILES Nc1cc2c3ccccc3ccc2c2ccccc12 Storage condition 2-8°C |
| Use of | 6-Aminochrysene (6-Aminochrysene) is an aromatic amine used as a chemotherapeutic agent in the treatment of splenomegaly, myeloid leukemia, and breast cancer. Properties Articles26 Name chrysen-6-amine Synonym More Synonyms 6-Aminochrysene Biological Activity Description 6-Aminochrysene (6-Aminochrysene) is an aromatic amine used as a chemotherapeutic agent in the treatment of splenomegaly, myeloid leukemia, and breast cancer. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer Research Areas >> Inflammation/Immunology In Vitro 6-Aminochrysene inhibits the hydroxylation of aniline, 0-demethylation of p-nitroanisole, and N-demethylation of aminopyrine by rat liver microsomes. Pre-treatment of rats with 6-aminochrysene markedly decreases the N-demethylation in vitro but significantly increases the hydroxylation and the 0-demethylation[1]. References [1]. Russo R, et al. Effects of 6-aminochrysene on liver microsomal enzyme activity. Xenobiotica. 1976 Apr;6(4):201-5. [2]. Lambelin G, et al. Carcinogenicity of 6-aminochrysene in mice. Eur J Cancer. 1975 May;11(5):327-34. Chemical & Physical Properties Molecular Formula C18H13N Exact Mass 243.104797 PSA 26.02000 Index of Refraction 1.814 InChIKey KIVUHCNVDWYUNP-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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