CAS Number52497-36-6
Synonyms2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid; MFCD03412037; (2S,3S,4R)-3-(carboxymethyl)-4-propan-2-ylpyrrolidine-2-carboxylic acid; Dihydrokainic acid
Molecular FormulaC10H17NO4
Molecular Weight215.25
Purity≥98 (HPLC)%
Density1.187g/cm3
Boiling Point416.6ºC at 760mmHg
Melting Point285 °C (dec.)
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 52497-36-6 |
| Catalog No. | 2A-9084547 |
| Chinese Name | 二氢红藻氨酸 |
| Synonyms | 2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid; MFCD03412037; (2S,3S,4R)-3-(carboxymethyl)-4-propan-2-ylpyrrolidine-2-carboxylic acid; Dihydrokainic acid |
| Molecular Formula | C10H17NO4 |
| Molecular Weight | 215.25 |
| Purity | ≥98 (HPLC) |
| Density | 1.187g/cm3 |
| Boiling Point | 416.6ºC at 760mmHg |
| Melting Point | 285 °C (dec.) |
| Appearance | powder |
| Storage Condition | Keep the container sealed and stored in a cool, dr |
| Application | Dihydrokainic acid (DHK) is an inhibitor of the glutamate transporter GLT1 (EAAT2). Dihydrokainic acid impairs novel object recognition (NOR) memory in mice. Dihydrokainic acid also has epileptogenic |
| HTC | 2933990090 |
| PubChem ID | 24277981 |
| MDL Number | MFCD03412037 |
| SMILES | CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |
| InChI | 1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 |
| InChI Key | JQPDCKOQOOQUSC-OOZYFLPDSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352106 |
| Hazard Symbols | transportation |
| MSDS | msds/84547_1_52497_36_6.pdf |
| Bioactivity | Dihydrokainic acid (DHK) is a glutamate transporter GLT1 (EAAT2) inhibitor. Dihydrokainic acid impairs novel object recognition (NOR) memory performance in mice. Dihydrokainic acid also shows epileptogenic effects[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> EAAT2 Research Areas >> Neurological Disease Target GLT1[1] References [1]. Tian SW, et al. Glutamate transporter GLT1 inhibitor dihydrokainic acid impairs novel object recognition memory performance in mice. Physiol Behav. 2019 Feb 1;199:28-32. [2]. Butcher SP, et al. On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat. Neuropharmacology. 1988 Apr;27(4):375-81. Chemical & Physical Properties Density 1.187g/cm3 Boiling Point 416.6ºC at 760mmHg Melting Point 285 °C (dec.) Molecular Formula C10H17NO4 Molecular Weight 215.25 Exact Mass 215.11600 PSA 86.63000 LogP 0.73470 Index of Refraction 1.492 InChIKey JQPDCKOQOOQUSC-OOZYFLPDSA-N SMILES CC(C)C1CNC(C(=O)O)C1CC(=O)O Storage condition 2-8°C |
| Use of | Dihydrokainic acid (DHK) is a glutamate transporter GLT1 (EAAT2) inhibitor. Dihydrokainic acid impairs novel object recognition (NOR) memory performance in mice. Dihydrokainic acid also shows epileptogenic effects[1]. Properties Articles37 Name dihydrokainic acid Synonym More Synonyms Dihydrokainic acid Biological Activity Description Dihydrokainic acid (DHK) is a glutamate transporter GLT1 (EAAT2) inhibitor. Dihydrokainic acid impairs novel object recognition (NOR) memory performance in mice. Dihydrokainic acid also shows epileptogenic effects[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> EAAT2 Research Areas >> Neurological Disease References [1]. Tian SW, et al. Glutamate transporter GLT1 inhibitor dihydrokainic acid impairs novel object recognition memory performance in mice. Physiol Behav. 2019 Feb 1;199:28-32. [2]. Butcher SP, et al. On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat. Neuropharmacology. 1988 Apr;27(4):375-81. Chemical & Physical Properties Molecular Formula C10H17NO4 Exact Mass 215.11600 PSA 86.63000 LogP 0.73470 Index of Refraction 1.492 InChIKey JQPDCKOQOOQUSC-OOZYFLPDSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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