CAS Number52789-62-5
Synonyms1-AMINO-8-NAPHTHOL-2,4-DISULFONIC ACID MONOSODIUM SALT; MFCD00068275; Chicago Acid Hydrate; SS Acid Hydrate; Sodium Hydrogen 4-Amino-5-hydroxy-1,3-naphthalenedisulfonate Hydrate; Monosodium 1-Amino-8-naphthol-2,4-disulfonate Hydrate; EINECS 258-185-0; 4-Amino-5-hydroxy-1,3-naphthalenedisulfonic Acid Monosodium Salt Hydrate; 2S Acid Hydrate
Molecular FormulaC10H8NNaO7S2
Molecular Weight341.29
Density1.477 g/mL at 25 °C(lit.)
Boiling Point270-272 °C(lit.)
Melting Point12-16 °C(lit.)
AppearanceSolid;Light gray to Brown to Black powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 52789-62-5 |
| Catalog No. | 2A-9084374 |
| Chinese Name | 1-氨基-8-萘酚-2,4-二磺酸一钠盐水合物 |
| Synonyms | 1-AMINO-8-NAPHTHOL-2,4-DISULFONIC ACID MONOSODIUM SALT; MFCD00068275; Chicago Acid Hydrate; SS Acid Hydrate; Sodium Hydrogen 4-Amino-5-hydroxy-1,3-naphthalenedisulfonate Hydrate; Monosodium 1-Amino-8-naphthol-2,4-disulfonate Hydrate; EINECS 258-185-0; 4-Amino-5-hydroxy-1,3-naphthalenedisulfonic Acid Monosodium Salt Hydrate; 2S Acid Hydrate |
| Molecular Formula | C10H8NNaO7S2 |
| Molecular Weight | 341.29 |
| Density | 1.477 g/mL at 25 °C(lit.) |
| Boiling Point | 270-272 °C(lit.) |
| Melting Point | 12-16 °C(lit.) |
| Appearance | Solid;Light gray to Brown to Black powder to crystal |
| Water Solubility | Insoluble |
| Storage Condition | room temperature |
| Application | CaMKP inhibitor sodium is a selective ROCK1 inhibitor with an IC50 value of 14 nM. |
| HTC | 2922199090 |
| SMILES | Nc1c(S(=O)(=O)[O-])cc(S(=O)(=O)O)c2cccc(O)c12.O.O.[Na+] |
| InChI | InChI=1S/C10H9NO7S2.2Na/c11-10-8(20(16,17)18)4-7(19(13,14)15)5-2-1-3-6(12)9(5)10;;/h1-4,12H,11H2,(H,13,14,15)(H,16,17,18);;/q;2*+1/p-2 |
| InChI Key | CFHHFSZBVRLYLD-UHFFFAOYSA-M |
| Bioactivity | CaMKP inhibitor sodium is a selective inhibitor of ROCK1 with an IC50 value of 14 nM. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK Target IC50: 14 nM (ROCK1)[1]. In Vitro CaMKP inhibitor sodium at 1 μM reduces ROCK2 activity over 20-fold, under conditions in which the only other kinase tested that is significantly inhibited is MSK1 whose activity is reduced ~5-fold. CaMKP inhibitor sodium is a more selective ROCK2 inhibitor than the widely utilized ROCK inhibitor Y-27632 as assessed on kinase-specificity panel, and does not significantly inhibit LRRK2 even at doses as high as 30 μM (500-fold higher than IC50 of inhibition of ROCK2). CaMKP inhibitor sodium slightly inhibits RSK and p70S6K with IC50 of 0.78 μM and 1.94 μM, respectively. CaMKP inhibitor sodium significantly inhibits rat aortic ring dilation with IC50 of 190 nM[2]. In Vivo CaMKP inhibitor sodium has 61% oral bioavailability in male Sprague-Dawley rats. Oral administration of CaMKP inhibitor sodium at single doses of 3-30 mg/kg dramatically reduces mean arterial pressure in the spontaneously hypertensive rats (SHRs) in a dose-dependent manner, with a maximum decrease of 50 mmHg after approximately 2 hours treatment at dose of 30 mg/kg[1]. References [1]. Goodman KB et al Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. J Med Chem. 2007 Jan 11;50(1):6-9. [2]. Nichols RJ et al Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Biochem J. 2009 Oct 23;424(1):47-60. Chemical & Physical Properties Density 1.477 g/mL at 25 °C(lit.) Boiling Point 270-272 °C(lit.) Melting Point 12-16 °C(lit.) Molecular Formula C10H8NNaO7S2 Molecular Weight 341.29 Flash Point >230 °F Exact Mass 340.96400 PSA 174.58000 LogP 3.02120 Index of Refraction n20/D 1.498(lit.) InChIKey CFHHFSZBVRLYLD-UHFFFAOYSA-M SMILES Nc1c(S(=O)(=O)[O-])cc(S(=O)(=O)O)c2cccc(O)c12.O.O.[Na+] |
| Use of | CaMKP inhibitor sodium is a selective inhibitor of ROCK1 with an IC50 value of 14 nM. Properties Name 1-Amino-8-naphthol-2,4-disulfonic Acid Monosodium Salt Hydrate Synonym More Synonyms Biological Activity Description CaMKP inhibitor sodium is a selective inhibitor of ROCK1 with an IC50 value of 14 nM. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK IC50: 14 nM (ROCK1)[1]. In Vitro CaMKP inhibitor sodium at 1 μM reduces ROCK2 activity over 20-fold, under conditions in which the only other kinase tested that is significantly inhibited is MSK1 whose activity is reduced ~5-fold. CaMKP inhibitor sodium is a more selective ROCK2 inhibitor than the widely utilized ROCK inhibitor Y-27632 as assessed on kinase-specificity panel, and does not significantly inhibit LRRK2 even at doses as high as 30 μM (500-fold higher than IC50 of inhibition of ROCK2). CaMKP inhibitor sodium slightly inhibits RSK and p70S6K with IC50 of 0.78 μM and 1.94 μM, respectively. CaMKP inhibitor sodium significantly inhibits rat aortic ring dilation with IC50 of 190 nM[2]. References [1]. Goodman KB et al Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. J Med Chem. 2007 Jan 11;50(1):6-9. [2]. Nichols RJ et al Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Biochem J. 2009 Oct 23;424(1):47-60. Chemical & Physical Properties Molecular Formula C10H8NNaO7S2 Exact Mass 340.96400 PSA 174.58000 LogP 3.02120 InChIKey CFHHFSZBVRLYLD-UHFFFAOYSA-M |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 85.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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