CAS Number78957-84-3
Synonyms1-Butanaminium, 4-[[(5-chloro-1-naphthalenyl)sulfonyl]amino]-, chloride (1:1); N-(4-Aminobutyl)-5-chloronaphthalene-1-sulfonamide hydrochloride (1:1); N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride; 4-{[(5-Chloro-1-naphthyl)sulfonyl]amino}-1-butanaminium chloride; N-(4-Aminobutyl)-5-chloro-1-naphthalenesulphonamide hydrochloride; OR0190T; Calmodulin antagonist-1
Molecular FormulaC14H18Cl2N2O2S
Molecular Weight349.28
Boiling Point501.5ºC at 760 mmHg
Melting Point243-246ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 78957-84-3 |
| Catalog No. | 2A-9084369 |
| Chinese Name | N-(4-氨基丁基)-5-氯-1-萘磺酰胺盐酸盐 |
| Synonyms | 1-Butanaminium, 4-[[(5-chloro-1-naphthalenyl)sulfonyl]amino]-, chloride (1:1); N-(4-Aminobutyl)-5-chloronaphthalene-1-sulfonamide hydrochloride (1:1); N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride; 4-{[(5-Chloro-1-naphthyl)sulfonyl]amino}-1-butanaminium chloride; N-(4-Aminobutyl)-5-chloro-1-naphthalenesulphonamide hydrochloride; OR0190T; Calmodulin antagonist-1 |
| Molecular Formula | C14H18Cl2N2O2S |
| Molecular Weight | 349.28 |
| Boiling Point | 501.5ºC at 760 mmHg |
| Melting Point | 243-246ºC |
| Storage Condition | -20°C, dry, sealed |
| Application | Calmodulin Antagonist-1 (W-7) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated calcium-phosphodiesterase (PDE) (IC50=28μM). Calmodulin antagonist-1 also inhibits |
| HTC | 2935009090 |
| SMILES | Cl.NCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12 |
| InChI Key | IKMXJMNRHREPOD-UHFFFAOYSA-N |
| Use of | Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated Ca2+-phosphodiesterase (PDE) (IC50=28 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca2+-PDE (IC50=375 μM) in a competitive fashion with respect to cyclic GMP and the Ki value is 300 μM[1]. Properties Name N-(4-aminobutyl)-5-chloronaphthalene-1-sulfonamide,hydrochloride Synonym More Synonyms Calmodulin antagonist-1 Biological Activity Description Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated Ca2+-phosphodiesterase (PDE) (IC50=28 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca2+-PDE (IC50=375 μM) in a competitive fashion with respect to cyclic GMP and the Ki value is 300 μM[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Neuronal Signaling >> CaMK References [1]. Itoh H, et al. Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase. J Biochem. 1984;96(6):1721-1726. Chemical & Physical Properties Exact Mass 348.046600 PSA 80.57000 LogP 5.48440 InChIKey IKMXJMNRHREPOD-UHFFFAOYSA-N Safety Information HS Code 2935009090 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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