CAS Number1684-40-8
Synonyms1,2,3,4-Tetrahydroacridin-9-amine hydrochloride (1:1); 1,2,3,4-Tetrahydroacridin-9-aminhydrochlorid; 9-Acridinamine, 1,2,3,4-tetrahydro-, hydrochloride, hydrate (1:1:2); 1,2,3,4-tetrahydroacridin-9-amine hydrochloride; Cognex; 9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate; 1,2,3,4-Tetrahydro-9-acridinamine hydrochloride (1:1); THA; 1,2,3,4-tetrahydroacridin-9-amine,hydrochloride; 1,2,3,4-Tetrahydro-9-acridinamine hydrochloride dihydrate; EINECS 216-867-5; MFCD00012657; 9-Acridinamine, 1,2,3,4-tetrahydro-, hydrochloride (1:1); 1,2,3,4-tétrahydroacridin-9-amine chlorhydrate; Tacrin hydrochloride
Molecular FormulaC13H15N2Cl1
Molecular Weight234.73
Boiling Point409.4ºC at 760mmHg
Melting Point280-284 °C(lit.)
AppearanceLight yellow solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1684-40-8 |
| Catalog No. | 2A-9083784 |
| Chinese Name | 9-氨基-1,2,3,4-四氢吖啶盐酸盐水合物 |
| Synonyms | 1,2,3,4-Tetrahydroacridin-9-amine hydrochloride (1:1); 1,2,3,4-Tetrahydroacridin-9-aminhydrochlorid; 9-Acridinamine, 1,2,3,4-tetrahydro-, hydrochloride, hydrate (1:1:2); 1,2,3,4-tetrahydroacridin-9-amine hydrochloride; Cognex; 9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate; 1,2,3,4-Tetrahydro-9-acridinamine hydrochloride (1:1); THA; 1,2,3,4-tetrahydroacridin-9-amine,hydrochloride; 1,2,3,4-Tetrahydro-9-acridinamine hydrochloride dihydrate; EINECS 216-867-5; MFCD00012657; 9-Acridinamine, 1,2,3,4-tetrahydro-, hydrochloride (1:1); 1,2,3,4-tétrahydroacridin-9-amine chlorhydrate; Tacrin hydrochloride |
| Molecular Formula | C13H15N2Cl1 |
| Molecular Weight | 234.73 |
| Boiling Point | 409.4ºC at 760mmHg |
| Melting Point | 280-284 °C(lit.) |
| Appearance | Light yellow solid |
| Storage Condition | Store airtight at 2-8°C |
| Packaging | II |
| Application | Tacrine hydrochloride is a potent inhibitor of AChE and BChE with IC50 values of 31 nM and 25.6 nM respectively. Tacrine hydrochloride is also an NMDAR inhibitor with an IC50 value of 26 μM. Tacrine |
| HTC | 2933990090 |
| MDL Number | MFCD00012657 |
| SMILES | Cl.Nc1c2c(nc3ccccc13)CCCC2 |
| InChI | InChI=1S/C13H14N2.ClH/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;/h1,3,5,7H,2,4,6,8H2,(H2,14,15);1H |
| InChI Key | ZUFVXZVXEJHHBN-UHFFFAOYSA-N |
| Hazard Symbols | 6.1(a) |
| MSDS | msds/83784_1_1684_40_8.pdf |
| Use of | Tacrine hydrochloride is a potent inhibitor of both AChE and BChE, with IC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer's disease[1][2]. Properties Name 9-Amino-1,2,3,4-tetrahydroacridine Hydrochloride Dihydrate Synonym More Synonyms Tacrine hydrochloride Biological Activity Description Tacrine hydrochloride is a potent inhibitor of both AChE and BChE, with IC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer's disease[1][2]. Related Catalog Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> AChE IC50: 31 nM (AChE), 25.6 nM (BChE), 26 μM (NMDAR)[1][2] References [2]. Horak M, et, al. The pharmacology of tacrine at N-methyl-d-aspartate receptors. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75: 54-62. [3]. The protective role of tacrine and donepezil in the retina of acetylcholinesterase knockout mice. Yi YM, et, al. Int J Ophthalmol. 2015 Oct 18; 8(5): 884-90. Chemical & Physical Properties Exact Mass 270.113495 PSA 38.91000 LogP 4.07900 InChIKey ZUFVXZVXEJHHBN-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Acridine, 1,2,3,4-tetrahydro-9-amino-, monohydrochloride CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T C666 BN&&TJ IZ &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5600 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07602 Safety Information Signal Word Danger Hazard Statements H301-H315-H319-H335 Precautionary Statements Missing Phrase - N15.00950417-P305 + P351 + P338 Hazard Codes T: Toxic;Xn: Harmful; Safety Phrases S26-S36-S45 WGK Germany 3 RTECS AR9532500 Packaging Group II Hazard Class 6.1(a) HS Code 2933990090 Synthetic Route Total: 1 Page CAS#:321-64-2 Tacrine hydroch... CAS#:1684-40-8 Literature: European Journal of Medicinal Chemistry, , vol. 77, p. 343 - 350 Precursor & DownStream Precursor 1 CAS#:321-64-2 DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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