CAS Number38966-21-1
Synonyms9-dimethanol,tetradecahydro-3,9-11a-methano-11ah-cyclohepta(a)naphthalene-4; Aphidicholin; Apchidicolin; MFCD00083214; APC; Aphidicolin from Nigrospora sphaerica; APHIDICOLIN; UNII:6B3F8QW8TU; aphidocolin; (3a,4a,5a,17a)-3,17-Dihydroxy-4-methyl-9,15-cyclo- C,18-dinor-14,15-secoandrostane-4,17-dimethanol
Molecular FormulaC20H34O4
Molecular Weight338.48
Purity≥98 (HPLC)%
Density1.2±0.1 g/cm3
Boiling Point507.8±50.0 °C at 760 mmHg
Melting Point227-233 °C (lit.)
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 38966-21-1 |
| Catalog No. | 2A-9083770 |
| Chinese Name | 阿非科林 |
| Synonyms | 9-dimethanol,tetradecahydro-3,9-11a-methano-11ah-cyclohepta(a)naphthalene-4; Aphidicholin; Apchidicolin; MFCD00083214; APC; Aphidicolin from Nigrospora sphaerica; APHIDICOLIN; UNII:6B3F8QW8TU; aphidocolin; (3a,4a,5a,17a)-3,17-Dihydroxy-4-methyl-9,15-cyclo- C,18-dinor-14,15-secoandrostane-4,17-dimethanol |
| Molecular Formula | C20H34O4 |
| Molecular Weight | 338.48 |
| Purity | ≥98 (HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 507.8±50.0 °C at 760 mmHg |
| Melting Point | 227-233 °C (lit.) |
| Appearance | powder |
| Storage Condition | This product should be sealed and stored dry at 4° |
| Application | Aphidicolin is an inhibitor of DNA polymerase alpha and delta and prevents mitotic cell division by interfering with the activity of DNA polymerase. Aphidicolin is an antibiotic produced by Cephalospo |
| PubChem ID | 57653817 |
| MDL Number | MFCD00083214 |
| SMILES | [H][C@@]12CC[C@@]3([H])[C@](C)(CO)[C@H](O)CC[C@]3(C)[C@]14CC[C@](O)(CO)[C@]([H])(C2)C4 |
| InChI | 1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1 |
| InChI Key | NOFOAYPPHIUXJR-APNQCZIXSA-N |
| Beilstein/REAXYS | 4689958 |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/83770_1_38966_21_1.pdf |
| Bioactivity | Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering with the activity of DNA polymerase[1].Aphidicolin is an antibiotic produced by the mold Cephalosporium aphidicola. Aphidicolin is a potent inhibitor of cellular deoxyribonucleic acid synthesis and inhibits the growth of herpes simplex virus[2].Aphidicolin potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line[3]. Related Catalog Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Inflammation/Immunology References [1]. Dresler SL, et al. Involvement of DNA polymerase delta in DNA repair synthesis in human fibroblasts at late times after ultraviolet irradiation. Biochemistry. 1988 Aug 23;27(17):6379-83. [2]. Bucknall RA, et al. Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola. Antimicrob Agents Chemother. 1973 Sep;4(3):294-8. [3]. Kuwakado K, et al. Aphidicolin potentiates apoptosis induced by arabinosyl nucleosides in human myeloid leukemiacell lines. Biochem Pharmacol. 1993 Dec 3;46(11):1909-16. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 507.8±50.0 °C at 760 mmHg Melting Point 225-233ºC Molecular Formula C20H34O4 Molecular Weight 338.482 Flash Point 230.4±24.7 °C Exact Mass 338.245697 PSA 80.92000 LogP 1.69 Vapour Pressure 0.0±3.0 mmHg at 25°C Index of Refraction 1.586 InChIKey NOFOAYPPHIUXJR-APNQCZIXSA-N SMILES CC1(CO)C(O)CCC2(C)C1CCC1CC3CC12CCC3(O)CO |
| Use of | Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering with the activity of DNA polymerase[1].Aphidicolin is an antibiotic produced by the mold Cephalosporium aphidicola. Aphidicolin is a potent inhibitor of cellular deoxyribonucleic acid synthesis and inhibits the growth of herpes simplex virus[2].Aphidicolin potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line[3]. Properties Articles1469 Name aphidicolin Synonym More Synonyms (+)-Aphidicolin Biological Activity Description Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering with the activity of DNA polymerase[1].Aphidicolin is an antibiotic produced by the mold Cephalosporium aphidicola. Aphidicolin is a potent inhibitor of cellular deoxyribonucleic acid synthesis and inhibits the growth of herpes simplex virus[2].Aphidicolin potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line[3]. Related Catalog Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Inflammation/Immunology References [1]. Dresler SL, et al. Involvement of DNA polymerase delta in DNA repair synthesis in human fibroblasts at late times after ultraviolet irradiation. Biochemistry. 1988 Aug 23;27(17):6379-83. [2]. Bucknall RA, et al. Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola. Antimicrob Agents Chemother. 1973 Sep;4(3):294-8. [3]. Kuwakado K, et al. Aphidicolin potentiates apoptosis induced by arabinosyl nucleosides in human myeloid leukemiacell lines. Biochem Pharmacol. 1993 Dec 3;46(11):1909-16. Chemical & Physical Properties Molecular Formula C20H34O4 Exact Mass 338.245697 PSA 80.92000 Index of Refraction 1.586 InChIKey NOFOAYPPHIUXJR-APNQCZIXSA-N |
| Transport Info | Product Name: Efedikonine |
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