CAS Number24280-93-1
SynonymsMycophenolic acid; melbex; 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid; EINECS 246-119-3; micofenolicoacido; 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-4-hexenoic acid; Micophenolic acid; Mycophenolinsure; Mycophenolic; mycophenolate; MFCD00036814; 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Molecular FormulaC17H20O6
Molecular Weight320.34
Purity98%
Density1.3±0.1 g/cm3
Boiling Point611.6±55.0 °C at 760 mmHg
Melting Point141°C
AppearanceWhite to off-white powder
EINECS246-119-3
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 24280-93-1 |
| Catalog No. | 2A-9008326 |
| Chinese Name | 霉酚酸 |
| Synonyms | Mycophenolic acid; melbex; 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid; EINECS 246-119-3; micofenolicoacido; 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-4-hexenoic acid; Micophenolic acid; Mycophenolinsure; Mycophenolic; mycophenolate; MFCD00036814; 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid |
| Molecular Formula | C17H20O6 |
| Molecular Weight | 320.34 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 611.6±55.0 °C at 760 mmHg |
| Melting Point | 141°C |
| Appearance | White to off-white powder |
| Water Solubility | methanol: 50 mg/mL, clear, colorless to faintly ye |
| Storage Condition | 2-8℃ |
| Packaging | III |
| Application | Mycophenolic acid (MPA) is an immunosuppressant with anti-proliferative activity. |
| EINECS | 246-119-3 |
| HTC | 2932209090 |
| SMILES | CC1=C2COC(=O)C2=C(C(=C1OC)C/C=C(\C)/CCC(=O)O)O |
| InChI | InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+ |
| InChI Key | HPNSFSBZBAHARI-RUDMXATFSA-N |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| Risk Codes | R22 |
| MSDS | msds/8326_1_24280_93_1.pdf |
| Bioactivity | Mycophenolic acid is an an immunosuppresant drug and has potent anti-proliferative activity.Target: OthersMycophenolic acid(MPA) is an immunosuppressant drug used to prevent rejection in organ transplantation. It inhibits an enzyme needed for the growth of T cells and B cells. MPA did not block the initial phase of viral translation but did interfere with viral protein synthesis in the amplification phase. Quantitative RT-PCR demonstrated that MPA prevented the accumulation of viral positive- and negative-strand RNA as the infection proceeded. MPA inhibits flavivirus infection by preventing synthesis and accumulation of viral RNA [1]. The effects of mycophenolic acid (MPA) on DEN replication in monkey kidney (LLC-MK2) cells were examined. MPA (IC(50)=0.4±0.3 microM) inhibited DEN2 replication. Quantitative real-time RT-PCR of viral RNA and plaque assays of virions from DEN2-infected and MPA (10 microM) -treated cells showed a fivefold increase in defective viral RNA production by cells treated with each drug. suggesting that one mode of antiviral action of MPA is by inhibition of inosine monophosphate dehydrogenase and thereby depletion of the intracellular GTP pool [2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology References [1]. Diamond, M.S., M. Zachariah, and E. Harris, Mycophenolic acid inhibits dengue virus infection by preventing replication of viral RNA. Virology, 2002. 304(2): p. 211-21. [2]. Takhampunya, R., et al., Inhibition of dengue virus replication by mycophenolic acid and ribavirin. J Gen Virol, 2006. 87(Pt 7): p. 1947-52. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 611.6±55.0 °C at 760 mmHg Melting Point 141°C Molecular Formula C17H20O6 Molecular Weight 320.337 Flash Point 225.8±25.0 °C Exact Mass 320.125977 PSA 93.06000 LogP 2.92 Vapour Pressure 0.0±1.8 mmHg at 25°C Index of Refraction 1.585 InChIKey HPNSFSBZBAHARI-RUDMXATFSA-N SMILES COc1c(C)c2c(c(O)c1CC=C(C)CCC(=O)O)C(=O)OC2 Storage condition 2-8°C Water Solubility methanol: 50 mg/mL, clear, colorless to faintly yellow |
| Use of | Properties Articles205 Name Mycophenolic acid Synonym More Synonyms Mycophenolic acid Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology References [1]. Diamond, M.S., M. Zachariah, and E. Harris, Mycophenolic acid inhibits dengue virus infection by preventing replication of viral RNA. Virology, 2002. 304(2): p. 211-21. [2]. Takhampunya, R., et al., Inhibition of dengue virus replication by mycophenolic acid and ribavirin. J Gen Virol, 2006. 87(Pt 7): p. 1947-52. Chemical & Physical Properties Molecular Formula C17H20O6 Exact Mass 320.125977 PSA 93.06000 Index of Refraction 1.585 InChIKey HPNSFSBZBAHARI-RUDMXATFSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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