CAS Number541-91-3
SynonymsEINECS 208-795-8; MFCD00211114; FEMA 3434; Musk; 3-Methylcyclopentadecanone; Muskone; DL-MUSCONE; dl-Muscone or 3-Methylcyclopentadecanone; Musk Ketone; moschusketone; MUSCONE; MUSCONE II
Molecular FormulaC16H30O
Molecular Weight238.41
Purity≥90.0 (GC)%
Density0.8±0.1 g/cm3
Boiling Point329.5±10.0 °C at 760 mmHg
Melting Point33ºC
AppearanceWhite to light yellow semi-solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 541-91-3 |
| Catalog No. | 2A-9008325 |
| Chinese Name | 麝香酮 |
| Synonyms | EINECS 208-795-8; MFCD00211114; FEMA 3434; Musk; 3-Methylcyclopentadecanone; Muskone; DL-MUSCONE; dl-Muscone or 3-Methylcyclopentadecanone; Musk Ketone; moschusketone; MUSCONE; MUSCONE II |
| Molecular Formula | C16H30O |
| Molecular Weight | 238.41 |
| Purity | ≥90.0 (GC) |
| Density | 0.8±0.1 g/cm3 |
| Boiling Point | 329.5±10.0 °C at 760 mmHg |
| Melting Point | 33ºC |
| Appearance | White to light yellow semi-solid |
| Storage Condition | Store in a cool, dry, well-ventilated warehouse. K |
| Application | Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits activation of NF-κB and NLRP3 inflammasome. Muscone significantly reduces inflammatory cytokines (IL-1β, TNF-α |
| HTC | 2914700090 |
| MDL Number | MFCD00211114 |
| SMILES | O=C1CC(CCCCCCCCCCCC1)C |
| InChI | 1S/C16H30O/c1-15-12-10-8-6-4-2-3-5-7-9-11-13-16(17)14-15/h15H,2-14H2,1H3 |
| InChI Key | ALHUZKCOMYUFRB-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/8325_1_541_91_3.pdf |
| Bioactivity | Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology Target NF-κB NLRP3 TNF-α IL-1β IL-6 In Vitro Muscone significantly downregulates the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in Bone marrow-derived macrophages (BMDMs). Muscone serves as a promising and effective drug for post-myocardial infarction (MI) treatment[1]. References [1]. Du Y, et al. Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome. Am J Transl Res. 2018 Dec 15;10(12):4235-4246. Chemical & Physical Properties Density 0.8±0.1 g/cm3 Boiling Point 329.5±10.0 °C at 760 mmHg Melting Point 33ºC Molecular Formula C16H30O Molecular Weight 238.409 Flash Point 145.3±11.3 °C Exact Mass 238.229660 PSA 17.07000 LogP 6.33 Vapour Pressure 0.0±0.7 mmHg at 25°C Index of Refraction 1.437 InChIKey ALHUZKCOMYUFRB-UHFFFAOYSA-N SMILES CC1CCCCCCCCCCCCC(=O)C1 Storage condition -20°C |
| Use of | Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate[1]. Properties Name 3-Methylcyclopentadecanone Synonym More Synonyms Muscone Biological Activity Description Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology In Vitro Muscone significantly downregulates the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in Bone marrow-derived macrophages (BMDMs). Muscone serves as a promising and effective drug for post-myocardial infarction (MI) treatment[1]. References [1]. Du Y, et al. Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome. Am J Transl Res. 2018 Dec 15;10(12):4235-4246. Chemical & Physical Properties Molecular Formula C16H30O Exact Mass 238.229660 PSA 17.07000 Index of Refraction 1.437 InChIKey ALHUZKCOMYUFRB-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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