CAS Number5370-01-4
Synonymsmexitil; Cirumimeru; 1-(2,6-dimethylphenoxy)propan-2-amine hydrochloride; ko1173; Katen; Mexiletine hydrochloride; MFCD00216024; 1-(2,6-Dimethylphenoxy)propan-2-aminium chloride; Ritalmex; 1-(2,6-dimethylphenoxy)propan-2-aminhydrochlorid; EINECS 226-362-1; Mexilitene; 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (1:1); Mexiletene hydrochloride; 1-(2,6-Dimethylphenoxy)propan-2-amine hydrochloride (1:1); 2-Propanamine, 1-(2,6-dimethylphenoxy)-, hydrochloride (1:1); UNII:606D60IS38; 1-(2,6-Dimethylphenoxy)-2-propylamine Hydrochloride; MEXILITINE HCL; Olzoron; 1-(2,6-diméthylphénoxy)propan-2-amine chlorhydrate; Mexiletine HCl; Toy
Molecular FormulaC11H18O1N1Cl1
Molecular Weight215.72
Purity97%
Density0.979 g/cm3
Boiling Point271.5ºC at 760 mmHg
Melting Point200-203°C
AppearanceWhite to off-white solid
EINECS226-362-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5370-01-4 |
| Catalog No. | 2A-9008316 |
| Chinese Name | 盐酸美西律 |
| Synonyms | mexitil; Cirumimeru; 1-(2,6-dimethylphenoxy)propan-2-amine hydrochloride; ko1173; Katen; Mexiletine hydrochloride; MFCD00216024; 1-(2,6-Dimethylphenoxy)propan-2-aminium chloride; Ritalmex; 1-(2,6-dimethylphenoxy)propan-2-aminhydrochlorid; EINECS 226-362-1; Mexilitene; 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (1:1); Mexiletene hydrochloride; 1-(2,6-Dimethylphenoxy)propan-2-amine hydrochloride (1:1); 2-Propanamine, 1-(2,6-dimethylphenoxy)-, hydrochloride (1:1); UNII:606D60IS38; 1-(2,6-Dimethylphenoxy)-2-propylamine Hydrochloride; MEXILITINE HCL; Olzoron; 1-(2,6-diméthylphénoxy)propan-2-amine chlorhydrate; Mexiletine HCl; Toy |
| Molecular Formula | C11H18O1N1Cl1 |
| Molecular Weight | 215.72 |
| Purity | 97 |
| Density | 0.979 g/cm3 |
| Boiling Point | 271.5ºC at 760 mmHg |
| Melting Point | 200-203°C |
| Appearance | White to off-white solid |
| Water Solubility | ethanol: 50 mg/mL |
| Storage Condition | 2-8°C |
| Application | Mexiletine hydrochloride is a sodium ion channel blocker and Class IB antiarrhythmic compound. |
| EINECS | 226-362-1 |
| HTC | 2922199090 |
| MDL Number | MFCD00216024 |
| SMILES | Cc1cccc(C)c1OCC(C)N.Cl |
| InChI | InChI=1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H |
| InChI Key | NFEIBWMZVIVJLQ-UHFFFAOYSA-N |
| Hazard Symbols | Xn |
| Risk Codes | R22;R36/37/38 |
| Safety Description | S26;S36 |
| MSDS | msds/8316_1_5370_01_4.pdf |
| Bioactivity | Mexiletine hydrochloride is a non-selective voltage-gated sodium channel blocker; Class IB anti-arrhythmic compound. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cardiovascular Disease References [1]. Desaphy JF, et al. Effect of mexiletine on sea anemone toxin-induced non-inactivating sodium channels of rat skeletal muscle: a model of sodium channel myotonia. Neuromuscul Disord. 1999 May;9(3):182-9. [2]. Mori K, et al. Inhibitory effects of class I and IV antiarrhythmic drugs on the Na+-activated K+ channel current in guinea pig ventricular cells. Naunyn Schmiedebergs Arch Pharmacol. 1998 Dec;358(6):641-8. Chemical & Physical Properties Density 0.979 g/cm3 Boiling Point 271.5ºC at 760 mmHg Melting Point 200-203°C Molecular Formula C11H18ClNO Molecular Weight 215.720 Flash Point 112.2ºC Exact Mass 215.107697 PSA 35.25000 LogP 3.53170 InChIKey NFEIBWMZVIVJLQ-UHFFFAOYSA-N SMILES Cc1cccc(C)c1OCC(C)N.Cl Storage condition 2-8°C Water Solubility ethanol: 50 mg/mL |
| Use of | Mexiletine hydrochloride is a non-selective voltage-gated sodium channel blocker; Class IB anti-arrhythmic compound. Properties Articles35 Name mexiletine hydrochloride Synonym More Synonyms Mexiletine hydrochloride Biological Activity Description Mexiletine hydrochloride is a non-selective voltage-gated sodium channel blocker; Class IB anti-arrhythmic compound. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cardiovascular Disease References [1]. Desaphy JF, et al. Effect of mexiletine on sea anemone toxin-induced non-inactivating sodium channels of rat skeletal muscle: a model of sodium channel myotonia. Neuromuscul Disord. 1999 May;9(3):182-9. [2]. Mori K, et al. Inhibitory effects of class I and IV antiarrhythmic drugs on the Na+-activated K+ channel current in guinea pig ventricular cells. Naunyn Schmiedebergs Arch Pharmacol. 1998 Dec;358(6):641-8. Chemical & Physical Properties Exact Mass 215.107697 PSA 35.25000 LogP 3.53170 InChIKey NFEIBWMZVIVJLQ-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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