CAS Number526-31-8
Synonymsa-Methylamino-b-(3-indole)propionic Acid; H-METRP-OH; L-Abrine; Abrine; EINECS 208-388-5; ABRINE,L; MFCD00005645; N-ME-TRP-OH HCL; N-ME-TRP-OH
Molecular FormulaC12H14N2O2
Molecular Weight218.25
Purity99%
Density1.3±0.1 g/cm3
Boiling Point439.1±35.0 °C at 760 mmHg
Melting Point>300 °C (dec.) (lit.)
Appearancewhite powder
EINECS208-388-5
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 526-31-8 |
| Catalog No. | 2A-9082941 |
| Chinese Name | 相思豆毒素 |
| Synonyms | a-Methylamino-b-(3-indole)propionic Acid; H-METRP-OH; L-Abrine; Abrine; EINECS 208-388-5; ABRINE,L; MFCD00005645; N-ME-TRP-OH HCL; N-ME-TRP-OH |
| Molecular Formula | C12H14N2O2 |
| Molecular Weight | 218.25 |
| Purity | 99 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 439.1±35.0 °C at 760 mmHg |
| Melting Point | >300 °C (dec.) (lit.) |
| Appearance | white powder |
| Storage Condition | Sealed and stored dry at 4 ºC |
| Application | L-(+)-Abrine, a lethal albumin found in Abrus precatorius seeds, is an acutely toxic alkaloid that can be used as a chemical marker. |
| EINECS | 208-388-5 |
| HTC | 2933990090 |
| PubChem ID | 24867181 |
| MDL Number | MFCD00005645 |
| SMILES | CN[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |
| InChI | 1S/C12H14N2O2/c1-13-11(12(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,13-14H,6H2,1H3,(H,15,16)/t11-/m0/s1 |
| InChI Key | CZCIKBSVHDNIDH-NSHDSACASA-N |
| Beilstein/REAXYS | 86638 |
| NACRES Code | NA.22 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| MSDS | msds/82941_1_526_31_8.pdf |
| Bioactivity | L-(+)-Abrine, a lethal albumin found in Abrus precatorius seeds, is an acute toxic alkaloid and chemical marker for abrin. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Others In Vitro L-(+)-Abrine is a marker for abrin poisoning. A strong indication for abrin poisoning is the presence of the chemical maker L-(+)-Abrine, which can survive metabolism in significant amounts making it detectable in human urine[1]. In Vivo Abrin is a toxic protein found in the jequirity seed. L-(+)-Abrine (L-Abrine) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. An animal study is designed to monitor the excretion and recovery of L-(+)-Abrine in 20 rats. The animals are exposed to one of three concentrations of L-(+)-Abrine, a single high concentration of L-tryptophan, or no agent (control). The low L-(+)-Abrine dose corresponds to 0.63 LD50 i.p. abrin in mice, assuming a concentration ratio of 1:4 of abrin to L-(+)-Abrine and an LD50 for abrin of 20 μg/kg. The mid and high L-(+)-Abrine (250 and 400 μg/kg) doses are included to ensure that the target analyte can be detected and tracked over the course of the experiment[2]. Animal Admin Rats[2] Twenty male Wistar rats, approximately 6-7 weeks of age and weighing approximately 175-200 g upon receipt, are used. A total of 12 rats are dosed intramuscularly with L-(+)-Abrine at 0.63, 3.13, and 5 times the expected Abrin LD50 of 20 μg/kg. Although no toxin is used here, the concentration of the biomarker is increased by a factor of 4 to estimate an equivalent level of toxin, assuming that Labrine is present in rosary peas at a concentration four times greater that the toxin abrin. A total of 12 rats are dosed intramuscularly with L-(+)-Abrine: four at approximately 50 μg/kg body weight (bw), four at 250 μg/kg bw, and four at 400 μg/kg bw. Four control rats are dosed with water, which is the vehicle for all dosing experiments. Another four rats are dosed intraperitoneally with 20,000 μg/kg L-tryptophan to verify that endogenous L-tryptophan is not metabolized to L-(+)-Abrine[2]. References [1]. Cho H, et al. A portable and chromogenic enzyme-based sensor for detection of abrin poisoning. Biosens Bioelectron. 2014 Apr 15;54:667-73. [2]. Johnson RC, et al. Quantification of L-abrine in human and rat urine: a biomarker for the toxin abrin. J Anal Toxicol. 2009 Mar;33(2):77-84. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 439.1±35.0 °C at 760 mmHg Melting Point >300 °C (dec.)(lit.) Molecular Formula C12H14N2O2 Molecular Weight 218.252 Flash Point 219.4±25.9 °C Exact Mass 218.105530 PSA 65.12000 LogP 1.18 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.649 InChIKey CZCIKBSVHDNIDH-NSHDSACASA-N SMILES CNC(Cc1c[nH]c2ccccc12)C(=O)O |
| Use of | L-(+)-Abrine, a lethal albumin found in Abrus precatorius seeds, is an acute toxic alkaloid and chemical marker for abrin. Properties Name Nα-methyl-L-tryptophan Synonym More Synonyms L-(+)-Abrine Biological Activity Description L-(+)-Abrine, a lethal albumin found in Abrus precatorius seeds, is an acute toxic alkaloid and chemical marker for abrin. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Others In Vitro L-(+)-Abrine is a marker for abrin poisoning. A strong indication for abrin poisoning is the presence of the chemical maker L-(+)-Abrine, which can survive metabolism in significant amounts making it detectable in human urine[1]. References [1]. Cho H, et al. A portable and chromogenic enzyme-based sensor for detection of abrin poisoning. Biosens Bioelectron. 2014 Apr 15;54:667-73. [2]. Johnson RC, et al. Quantification of L-abrine in human and rat urine: a biomarker for the toxin abrin. J Anal Toxicol. 2009 Mar;33(2):77-84. Chemical & Physical Properties Molecular Formula C12H14N2O2 Exact Mass 218.105530 PSA 65.12000 Index of Refraction 1.649 InChIKey CZCIKBSVHDNIDH-NSHDSACASA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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