CAS Number99-24-1
SynonymsMethyl gallate; MFCD00002194; 3,4,5-Trihydroxybenzoic acid methyl ester; Benzoic acid, 3,4,5-trihydroxy-, methyl ester; Methyl 3,4,5-trihydroxybenzoate; EINECS 202-741-7
Molecular Formula(HO)3C6H2CO2CH3
Molecular Weight184.15
Purity98%
Density1.5±0.1 g/cm3
Boiling Point450.1±40.0 °C at 760 mmHg
Melting Point201-203 °C (lit.)
AppearanceWhite to slightly beige crystalline powder
EINECS202-741-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 99-24-1 |
| Catalog No. | 2A-9008284 |
| Chinese Name | 没食子酸甲酯 |
| Synonyms | Methyl gallate; MFCD00002194; 3,4,5-Trihydroxybenzoic acid methyl ester; Benzoic acid, 3,4,5-trihydroxy-, methyl ester; Methyl 3,4,5-trihydroxybenzoate; EINECS 202-741-7 |
| Molecular Formula | (HO)3C6H2CO2CH3 |
| Molecular Weight | 184.15 |
| Purity | 98 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 450.1±40.0 °C at 760 mmHg |
| Melting Point | 201-203 °C (lit.) |
| Appearance | White to slightly beige crystalline powder |
| Water Solubility | SOLUBLE IN HOT WATER |
| Storage Condition | Store in a cool, ventilated warehouse. Keep away f |
| Application | Methyl gallate is a plant phenol with antioxidant, anticancer and anti-inflammatory activities. Methyl gallate also inhibits bacterial activity. |
| EINECS | 202-741-7 |
| HTC | 2918290000 |
| PubChem ID | 24856570 |
| MDL Number | MFCD00002194 |
| SMILES | COC(=O)c1cc(O)c(O)c(O)c1 |
| InChI | 1S/C8H8O5/c1-13-8(12)4-2-5(9)7(11)6(10)3-4/h2-3,9-11H,1H3 |
| InChI Key | FBSFWRHWHYMIOG-UHFFFAOYSA-N |
| Beilstein/REAXYS | 2113180 |
| NACRES Code | NA.23 |
| UNSPSC | 12162002 |
| Hazard Symbols | Xi |
| Risk Codes | R22;R36/37/38;R43 |
| Safety Description | S26;S36/37 |
| MSDS | msds/8284_1_99_24_1.pdf |
| Bioactivity | Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Cardiovascular Disease Research Areas >> Cancer Research Areas >> Infection Natural Products >> Phenols Target Bacterial[1] In Vitro The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutans and . sobrinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth of Lactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL)[1]. Methyl gallate, in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-term H2O2 treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from being depleted following an exposure of H2O2 (8.0 mM) for a 3 h period[2]. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. Furthermore, forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate[3]. Cell Assay KB cells, a human mouth epithelial cell line, are treated with Methyl gallate (1-8 mg/mL) for 24 h. Cytotoxicity of Methyl gallate is assessed by a modified MTT assay[1]. References [1]. Kang MS, et al. Inhibitory effect of methyl gallate and gallic acid on oral bacteria. J Microbiol. 2008 Dec;46(6):744-50. [2]. Hsieh TJ, et al. Protective effect of methyl gallate from Toona sinensis (Meliaceae) against hydrogen peroxide-induced oxidative stress and DNA damage in MDCK cells. Food Chem Toxicol. 2004 May;42(5):843-50. [3]. Lee H, et al. Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells. J Immunol. 2010 Dec 1;185(11):6698-705. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 450.1±40.0 °C at 760 mmHg Melting Point 201-204 °C Molecular Formula C8H8O5 Molecular Weight 184.146 Flash Point 190.8±20.8 °C Exact Mass 184.037170 PSA 86.99000 LogP 1.54 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.631 InChIKey FBSFWRHWHYMIOG-UHFFFAOYSA-N SMILES COC(=O)c1cc(O)c(O)c(O)c1 Storage condition 2-8°C Water Solubility SOLUBLE IN HOT WATER |
| Use of | Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity. Properties Articles40 Name Methyl Gallate Synonym More Synonyms Methyl gallate Biological Activity Description Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Cardiovascular Disease Research Areas >> Cancer Research Areas >> Infection Natural Products >> Phenols Bacterial[1] References [1]. Kang MS, et al. Inhibitory effect of methyl gallate and gallic acid on oral bacteria. J Microbiol. 2008 Dec;46(6):744-50. [2]. Hsieh TJ, et al. Protective effect of methyl gallate from Toona sinensis (Meliaceae) against hydrogen peroxide-induced oxidative stress and DNA damage in MDCK cells. Food Chem Toxicol. 2004 May;42(5):843-50. [3]. Lee H, et al. Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells. J Immunol. 2010 Dec 1;185(11):6698-705. Chemical & Physical Properties Molecular Formula C8H8O5 Exact Mass 184.037170 PSA 86.99000 Index of Refraction 1.631 InChIKey FBSFWRHWHYMIOG-UHFFFAOYSA-N Water Solubility SOLUBLE IN HOT WATER |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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