| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5874-97-5 |
| Catalog No. | 2A-9008194 |
| Chinese Name | 硫酸奥西那林 |
| Synonyms | Orciprenaline sulfate |
| Molecular Formula | C11H17NO3 · 1/2H2SO4 |
| Molecular Weight | 260.30 |
| Purity | 98 |
| Density | 1.199g/cm3 |
| Boiling Point | 417.5ºC at 760mmHg |
| Melting Point | 202-203° |
| Water Solubility | Freely soluble in water, slightly soluble in ethan |
| Storage Condition | -20°C, filled with argon |
| Application | Metaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic drug and beta2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol hemisulfate also has a |
| PubChem ID | 329750377 |
| MDL Number | MFCD00058303 |
| SMILES | OS(O)(=O)=O.CC(C)NCC(O)c1cc(O)cc(O)c1.CC(C)NCC(O)c2cc(O)cc(O)c2 |
| InChI | 1S/2C11H17NO3.H2O4S/c2*1-7(2)12-6-11(15)8-3-9(13)5-10(14)4-8;1-5(2,3)4/h2*3-5,7,11-15H,6H2,1-2H3;(H2,1,2,3,4) |
| InChI Key | MKFFGUZYVNDHIH-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/8194_1_5874_97_5.pdf |
| Bioactivity | Metaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity[1][2]. Related Catalog Research Areas >> Endocrinology Target IC50: 68 nM (β2-adrenergic receptor)[1] In Vitro Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages[1]. Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages[1]. Western Blot Analysis[1] Cell Line: THP-1 cells and bone marrow macrophages Concentration: 10 μM Incubation Time: 74 hours Result: Enhanced β-arrestin2 and its interaction with IκBα. RT-PCR[1] Cell Line: THP-1 cells and bone marrow macrophages Concentration: 10 μM Incubation Time: 74 hours Result: Led to downregulation of NF-κB. In Vivo Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications[1]. References [1]. Noh H, et al. Beta 2-adrenergic receptor agonists are novel regulators of macrophage activation in diabetic renal and cardiovascular complications. Kidney Int. 2017 Jul;92(1):101-113. [2]. Ibrahim FA, et al. Highly sensitive spectrofluorimetric method for rapid determination of orciprenaline in biological fluids and pharmaceuticals. Luminescence. 2019 Feb;34(1):77-83. Chemical & Physical Properties Density 1.199g/cm3 Boiling Point 417.5ºC at 760mmHg Melting Point 202-203° Molecular Formula C11H17NO3.1/2H2O4S Molecular Weight 520.59400 Flash Point 179.7ºC Exact Mass 520.20900 PSA 228.42000 LogP 3.46820 InChIKey MKFFGUZYVNDHIH-UHFFFAOYSA-N SMILES CC(C)NCC(O)c1cc(O)cc(O)c1.CC(C)NCC(O)c1cc(O)cc(O)c1.O=S(=O)(O)O Water Solubility Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
| Use of | Metaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity[1][2]. Properties Name Metaproterenol Hemisulfate Salt Synonym More Synonyms Orciprenaline sulfate Biological Activity Description Metaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity[1][2]. Related Catalog Research Areas >> Endocrinology IC50: 68 nM (β2-adrenergic receptor)[1] In Vivo Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications[1]. References [1]. Noh H, et al. Beta 2-adrenergic receptor agonists are novel regulators of macrophage activation in diabetic renal and cardiovascular complications. Kidney Int. 2017 Jul;92(1):101-113. [2]. Ibrahim FA, et al. Highly sensitive spectrofluorimetric method for rapid determination of orciprenaline in biological fluids and pharmaceuticals. Luminescence. 2019 Feb;34(1):77-83. Chemical & Physical Properties Exact Mass 520.20900 PSA 228.42000 LogP 3.46820 InChIKey MKFFGUZYVNDHIH-UHFFFAOYSA-N Water Solubility Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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