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Hydroxybrasilein structure, CAS 475-25-2

Hydroxybrasilein

CAS Number475-25-2

Synonymshydroxybrazilein; Haematein; EINECS 207-492-8

Molecular FormulaC16H12O6

Molecular Weight300.27

Purity

Density1.77g/cm3

Boiling Point753.1ºC at 760mmHg

Melting Point180ºC

Flash Point

Appearancedark brown crystalline powder

EINECS

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Cat. No.: 2A-9081619 Purity:
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Quality Control of [ 475-25-2 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number475-25-2
Catalog No.2A-9081619
Chinese Name氧化苏木精
Synonymshydroxybrazilein; Haematein; EINECS 207-492-8
Molecular FormulaC16H12O6
Molecular Weight300.27
Density1.77g/cm3
Boiling Point753.1ºC at 760mmHg
Melting Point180ºC
Appearancedark brown crystalline powder
Storage Condition2-8°C, dry, sealed
ApplicationHematein is the oxidation product of hematoxylin and can be used as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylatio
MDL NumberC16H12O6
SMILESOc1ccc2c(OCC3(O)CC4=CC(=O)C(=CC4=C23)O)c1O
InChIInChI=1S/C16H12O6/c17-10-2-1-8-13-9-4-12(19)11(18)3-7(9)5-16(13,21)6-22-15(8)14(10)20/h1-4,17,19-21H,5-6H2
InChI KeyInChIKey=HLUCICHZHWJHLL-UHFFFAOYSA-N
Hazard Symbolstransportation
MSDSmsds/81619_1_475_25_2.pdf
BioactivityHematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Wnt Signaling Pathways >> PI3K/Akt/mTOR >> Akt Target CKII:0.74 μM (IC50) Akt Wnt In Vitro Hematein (10-100 μM; 14 days) inhibits cells growth in A427 lung cancer cells[1]. Hematein (50 and 100 μM; 48 hours) induces apoptosis in A427 lung cancer cells[1]. Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation[1]. Cell Viability Assay[1] Cell Line: A427 (HTB-53) cell line Concentration: 10-100 μM Incubation Time: 14 days Result: Inhibited cells growth. Apoptosis Analysis[1] Cell Line: A427 (HTB-53) cell line Concentration: 50 and 100 μM Incubation Time: 48 hours Result: Induced apoptosis in A427 lung cancer cells. Western Blot Analysis[1] Cell Line: A427 (HTB-53) cell line Concentration: 50 and 100 μM Incubation Time: 48 hours Result: Inhibited CK2-specific Akt phosphorylation. In Vivo Hematein (intraperitoneal injections; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth in A427 lung cancer cell xenografts[1]. Animal Model: Female athymic BALB/c nude mice (6-week-old) [1] Dosage: 50 mg/kg Administration: Intraperitoneal injections; twice a week for 6 weeks Result: Inhibited tumor growth in A427 lung cancer cell xenografts. References [1]. Shirai, K., & Matsuoka, M. (1996). Structure and properties of hematein derivatives. Dyes and Pigments, 32(3), 159-169. [2]. Hung MS, et al. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograftmodel.Int J Oncol. 2013 Nov;43(5):1517-22. Chemical & Physical Properties Density 1.77g/cm3 Boiling Point 753.1ºC at 760mmHg Melting Point 180ºC Molecular Formula C16H12O6 Molecular Weight 300.26300 Flash Point 289ºC Exact Mass 300.06300 PSA 107.22000 LogP 1.32960 Vapour Pressure 1.32E-17mmHg at 25°C Index of Refraction 1.765
Use ofHematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2]. Properties Articles24 Name 3,4,6a,10-tetrahydroxy-6,7-dihydroindeno[2,1-c]chromen-9-one Synonym More Synonyms Hematein Biological Activity Description Hematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Wnt Signaling Pathways >> PI3K/Akt/mTOR >> Akt CKII:0.74 μM (IC50) References [1]. Shirai, K., & Matsuoka, M. (1996). Structure and properties of hematein derivatives. Dyes and Pigments, 32(3), 159-169. [2]. Hung MS, et al. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograftmodel.Int J Oncol. 2013 Nov;43(5):1517-22. Chemical & Physical Properties Molecular Formula C16H12O6 Exact Mass 300.06300 PSA 107.22000 LogP 1.32960 Index of Refraction 1.765
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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