CAS Number20448-79-7
Synonyms2-aminonorbornane-2-carboxylic acid; MFCD00167580; b-BCH; 2-AMINO-2-NORBORNANE-CARBOXYLIC ACID
Molecular FormulaC8H13NO2
Molecular Weight155.19400
Density1.256g/cm3
Boiling Point295.5ºC at 760 mmHg
Melting Point>300 °C(lit.)
AppearanceWhite to off-white powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 20448-79-7 |
| Catalog No. | 2A-9081437 |
| Chinese Name | 2-氨基二环[2.2.1]庚烷-2-羧酸 |
| Synonyms | 2-aminonorbornane-2-carboxylic acid; MFCD00167580; b-BCH; 2-AMINO-2-NORBORNANE-CARBOXYLIC ACID |
| Molecular Formula | C8H13NO2 |
| Molecular Weight | 155.19400 |
| Density | 1.256g/cm3 |
| Boiling Point | 295.5ºC at 760 mmHg |
| Melting Point | >300 °C(lit.) |
| Appearance | White to off-white powder |
| Storage Condition | Sealed, cool, dry place |
| Application | LAT1-IN-1 (BCH) is a selective competitive inhibitor of L-type amino acid transporter 1 (LAT1), which can significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, thereby inhibit |
| HTC | 2922499990 |
| SMILES | NC1(C(=O)O)CC2CCC1C2 |
| InChI | InChI=1S/C8H13NO2/c9-8(7(10)11)4-5-1-2-6(8)3-5/h5-6H,1-4,9H2,(H,10,11) |
| InChI Key | MPUVBVXDFRDIPT-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/81437_2_20448_79_7.pdf |
| Bioactivity | LAT1-IN-1 (BCH) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis[1][2][3]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Target LAT1[1] In Vitro LAT1-IN-1 (1-100 mM; 3 days; KYSE30 and KYSE150 esophageal cancer cells) treatment suppresses cell proliferation in a dose-dependent manner[1]. LAT1-IN-1 (30 mM; 24 and 48 hours; KYSE30 and KYSE150 cells) treatment significantly increases cell population in the G0/G1 phase in both KYSE30 and KYSE150 cells, indicating that LAT1-IN-1 induces cell cycle arrest at G1 phase[1]. LAT1-IN-1 (30 mM; 0-24 hours; KYSE30 and KYSE150 cells) treatment decreases phosphorylation of 4E-BP1 and p70S6K at 30 minutes and the decrease is continued for 24 hours. The amount of mTOR, 4E-BP1, and p70S6K proteins is slightly decreased[1]. Cell Proliferation Assay[1] Cell Line: KYSE30 and KYSE150 esophageal cancer cells Concentration: 1 mM, 3 mM, 5 mM, 10 mM, 20 mM, 30 mM, 40 mM, 50 mM, or 100 mM Incubation Time: 3 days Result: Cell proliferation was suppressed in a dose-dependent manner. Cell Cycle Analysis[1] Cell Line: KYSE30 and KYSE150 cells Concentration: 30 mM Incubation Time: 24 and 48 hours Result: Cell cycle arrest. Western Blot Analysis[1] Cell Line: KYSE30 and KYSE150 cells Concentration: 30 mM Incubation Time: 0 hour, 0.5 hour, 1 hour, 3 hours, 6 hours, 24 hours Result: Phosphorylation of 4E-BP1 and p70S6K was decreased. The amount of mTOR, 4E-BP1, and p70S6K proteins was slightly decreased. In Vivo LAT1-IN-1 (200 mg/kg; intravenous injection; daily; for 14 days; male BALB/c nude mice) treatment significantly delays tumor growth and decreases glucose metabolism, indicating that LAT1 inhibition potentially suppresses esophageal cancer growth in vivo[1]. Animal Model: Male BALB/c nude mice (5-week-old) with KYSE150 cells[1] Dosage: 200 mg/kg Administration: Intravenous injection; daily; for 14 days Result: Significantly delayed tumor growth and decreased glucose metabolism. References [1]. Ohshima Y, et al. Efficacy of system l amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma. Cancer Sci. 2016 Oct;107(10):1499-1505. [2]. Singh N, et al. Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods. Int J Mol Sci. 2018 Dec 21;20(1). [3]. Wang Q, et al. L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. Am J Cancer Res. 2015 Mar 15;5(4):1281-94. eCollection 2015. Chemical & Physical Properties Density 1.256g/cm3 Boiling Point 295.5ºC at 760 mmHg Melting Point >300 °C(lit.) Molecular Formula C8H13NO2 Molecular Weight 155.19400 Flash Point 132.5ºC Exact Mass 155.09500 PSA 63.32000 LogP 1.28880 Vapour Pressure 0.000369mmHg at 25°C Index of Refraction 1.559 InChIKey MPUVBVXDFRDIPT-UHFFFAOYSA-N SMILES NC1(C(=O)O)CC2CCC1C2 |
| Use of | LAT1-IN-1 (BCH) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis[1][2][3]. Properties Articles37 Name 3-aminobicyclo[2.2.1]heptane-3-carboxylic acid Synonym More Synonyms BCH Biological Activity Description LAT1-IN-1 (BCH) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis[1][2][3]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer References [1]. Ohshima Y, et al. Efficacy of system l amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma. Cancer Sci. 2016 Oct;107(10):1499-1505. [2]. Singh N, et al. Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods. Int J Mol Sci. 2018 Dec 21;20(1). [3]. Wang Q, et al. L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. Am J Cancer Res. 2015 Mar 15;5(4):1281-94. eCollection 2015. Chemical & Physical Properties Molecular Formula C8H13NO2 Exact Mass 155.09500 PSA 63.32000 LogP 1.28880 Index of Refraction 1.559 InChIKey MPUVBVXDFRDIPT-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | P. Quarantine of entry animals, plants, and animal and plant products Q. Quarantine of exit animals, plants, and animal and plant products R. Hygiene supervision and inspection of imported food S. Hyg |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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