CAS Number61-90-5
SynonymsMFCD00002617; Glusate; H-L-GLU-OH; Leucine; L-GLU; (l)-leucine; EINECS 200-522-0; H-GLU-OH; GLU; L-2-Amino-4-methylpentanoic acid; (2S)-α-Leucine; GLUTACID; 4-Methyl-L-norvaline; l-Leu; Leucinum; [3H]-L-Glutamic acid; Leucine (USP); L-Leucine; S-leucine; QVYZ1Y1&1 &&L or S Form; H-Leu-OH; (S)-2-amino-4-methyl-pentanoic acid; L-(+)-glutamic acid; (S)-(+)-Leucine; Aciglut; (S)-leucine; glutamic; L-(-)-2-Amino-4-methylpentanoic acid; LEU; Glutaton
Molecular FormulaC6H13NO2
Molecular Weight131.173
Purity98%
Density1.0±0.1 g/cm3
Boiling Point225.8±23.0 °C at 760 mmHg
Melting Point286-288 ºC
AppearanceWhite crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 61-90-5 |
| Catalog No. | 2A-9008133 |
| Chinese Name | L-亮氨酸 |
| Synonyms | MFCD00002617; Glusate; H-L-GLU-OH; Leucine; L-GLU; (l)-leucine; EINECS 200-522-0; H-GLU-OH; GLU; L-2-Amino-4-methylpentanoic acid; (2S)-α-Leucine; GLUTACID; 4-Methyl-L-norvaline; l-Leu; Leucinum; [3H]-L-Glutamic acid; Leucine (USP); L-Leucine; S-leucine; QVYZ1Y1&1 &&L or S Form; H-Leu-OH; (S)-2-amino-4-methyl-pentanoic acid; L-(+)-glutamic acid; (S)-(+)-Leucine; Aciglut; (S)-leucine; glutamic; L-(-)-2-Amino-4-methylpentanoic acid; LEU; Glutaton |
| Molecular Formula | C6H13NO2 |
| Molecular Weight | 131.173 |
| Purity | 98 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 225.8±23.0 °C at 760 mmHg |
| Melting Point | 286-288 ºC |
| Appearance | White crystalline powder |
| Water Solubility | 22.4 g/L (20 C) |
| Storage Condition | This product should be sealed, dry and protected f |
| Application | L-Leucine is an essential branched-chain amino acid (BCAA) that activates the mTOR signaling pathway [1]. |
| HTC | 29224995 |
| SMILES | CC(C)CC(N)C(=O)O |
| InChI | InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9) |
| InChI Key | ROHFNLRQFUQHCH-YFKPBYRVSA-N |
| Hazard Symbols | Transport |
| Bioactivity | L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1]. Related Catalog Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Natural Products >> Others Research Areas >> Metabolic Disease Target mTORC1 In Vitro L-Leucine (10 mM) treatment impairs endocrine progenitor cell development[1]. In E13.5 rat pancreatic explants, in absence of added L-Leucine, Ngn3 mRNA levels increased after 1 day of culture, peaked on day 3, and then decreased. When L-Leucine is added, a dramatic decrease is observed in Ngn3 mRNA levels. This decrease in Ngn3 mRNA levels was paralleled by a decrease in the number of Ngn3-expressing cells (4728±408 vs. 959±28; P<0.01). Finally, L-Leucine also caused a dose-dependent repressive effect on the mRNA levels of the three genes, namely Ngn3, its target Insm1, and insulin[1]. Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation. L-Leucine increases intracellular HIF-1α levels and activates the HIF-1α signaling pathway, and these two effects are mediated by the mTOR signaling pathway. This process results in Ngn3 repression and, consequently, decreases β-cell differentiation[1]. References [1]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 225.8±23.0 °C at 760 mmHg Melting Point 286-288 ºC Molecular Formula C6H13NO2 Molecular Weight 131.173 Flash Point 90.3±22.6 °C Exact Mass 131.094635 PSA 63.32000 LogP 0.73 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.463 InChIKey ROHFNLRQFUQHCH-YFKPBYRVSA-N SMILES CC(C)CC(N)C(=O)O Water Solubility 22.4 g/L (20 C) |
| Use of | L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1]. Properties Articles347 Name L-leucine Synonym More Synonyms L-leucine Biological Activity Description L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1]. Related Catalog Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Natural Products >> Others Research Areas >> Metabolic Disease References [1]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. Chemical & Physical Properties Molecular Formula C6H13NO2 Exact Mass 131.094635 PSA 63.32000 Index of Refraction 1.463 InChIKey ROHFNLRQFUQHCH-YFKPBYRVSA-N SMILES CC(C)CC(N)C(=O)O |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | P. Quarantine of entry animals, plants, and animal and plant products Q. Quarantine of exit animals, plants, and animal and plant products R. Hygiene supervision and inspection of imported food S. Hyg |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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