CAS Number1154-25-2
Synonymsethylisopropylamiloride; MFCD00151710; 3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide; 3-amino-6-chloro-n-(diaminomethylene)-5-[ethyl(isopropyl)amino]pyrazine-2-carboxamide; 3-Amino-6-chloro-N-(diaminomethylene)-5-[ethyl(isopropyl)amino]-2-pyrazinecarboxamide; EIPA
Molecular FormulaC11H18ClN7O
Molecular Weight299.76
Density1.5±0.1 g/cm3
Boiling Point543.9±60.0 °C at 760 mmHg
Melting Point202-205ºC(lit.)
AppearanceOff-white to yellow solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1154-25-2 |
| Catalog No. | 2A-9081165 |
| Chinese Name | 5-(N-乙基-N-异丙基)阿米洛利 |
| Synonyms | ethylisopropylamiloride; MFCD00151710; 3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide; 3-amino-6-chloro-n-(diaminomethylene)-5-[ethyl(isopropyl)amino]pyrazine-2-carboxamide; 3-Amino-6-chloro-N-(diaminomethylene)-5-[ethyl(isopropyl)amino]-2-pyrazinecarboxamide; EIPA |
| Molecular Formula | C11H18ClN7O |
| Molecular Weight | 299.76 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 543.9±60.0 °C at 760 mmHg |
| Melting Point | 202-205ºC(lit.) |
| Appearance | Off-white to yellow solid |
| Storage Condition | Sealed, store at 2 ºC -8 ºC |
| Packaging | III |
| Application | EIPA is a TRPP3 channel inhibitor with an IC50 value of 10.5 μM. EIPA also inhibits the increase in Na+/H+ exchangers (NHE) and macrophages. |
| HTC | 2934999090 |
| MDL Number | C11H18ClN7O |
| SMILES | CCN(c1nc(N)c(C(=O)N=C(N)N)nc1Cl)C(C)C |
| InChI | InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20) |
| InChI Key | QDERNBXNXJCIQK-UHFFFAOYSA-N |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/81165_1_1154_25_2.pdf |
| Use of | Properties Articles78 Name 5-(N-Ethyl-N-isopropyl) Amiloride Synonym More Synonyms EIPA Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer Research Areas >> Inflammation/Immunology References [2]. Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42(6):2418-2429. [3]. Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis. Chemical & Physical Properties Exact Mass 299.126129 PSA 134.01000 Index of Refraction 1.665 InChIKey QDERNBXNXJCIQK-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information Signal Word Warning Hazard Statements H315-H319-H335 Precautionary Statements P261-P305 + P351 + P338 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xi: Irritant; RIDADR UN 2811 Packaging Group III Hazard Class 6.1(b) HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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