| Chemical & Physical Properties | |
|---|---|
| CAS Number | 57602-02-5 |
| Catalog No. | 2A-9080717 |
| Chinese Name | 1,14-二溴-3,6,9,12-四恶十四烷 |
| Synonyms | 1,14-Dibromo-3,6,9,12-tetraoxatetradecane; 1,2-bis[2-(2-bromoethoxy)ethoxy]ethane |
| Molecular Formula | C10H20O4Br2 |
| Molecular Weight | 364.07 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 373.2±32.0 °C at 760 mmHg |
| Storage Condition | room temperature, dry |
| Application | Bromo-PEG4-bromide is a PROTAC linker, belonging to the PEG class. Bromo-PEG4-bromide can be used to synthesize PROTAC molecules. |
| HTC | 2909199090 |
| MDL Number | MFCD07369317 |
| SMILES | BrCCOCCOCCOCCOCCBr |
| InChI Key | VYNNYZUBABMNTB-UHFFFAOYSA-N |
| MSDS | msds/80717_1_57602_02_5.pdf |
| Use of | Bromo-PEG4-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Properties Name 1,14-Dibromo-3,6,9,12-tetraoxatetradecane Synonym More Synonyms Bromo-PEG4-bromide Biological Activity Description Bromo-PEG4-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Mulyana Y, et al. Oligonuclear polypyridylruthenium(II) complexes incorporating flexible polar and non-polar bridges: synthesis, DNA-binding and cytotoxicity. Dalton Trans. 2011 Feb 21;40(7):1510-23. [2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. Chemical & Physical Properties Molecular Formula C10H20Br2O4 Exact Mass 361.972809 PSA 36.92000 Index of Refraction 1.489 InChIKey VYNNYZUBABMNTB-UHFFFAOYSA-N SMILES BrCCOCCOCCOCCOCCBr Safety Information Hazard Codes Xi HS Code 2909199090 Synthetic Route Pentaethylene glycol CAS#:4792-15-8 Bromo-PEG4-bromide CAS#:57602-02-5 Literature: Biron, Eric; Otis, Francois; Meillon, Jean-Christophe; Robitaille, Martin; Lamothe, Julie; Van Hove, Patrick; Cormier, Marie-Eve; Voyer, Normand Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 6 p. 1279 - 1290 Pentaethylene G... CAS#:109789-39-1 Bromo-PEG4-bromide CAS#:57602-02-5 Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 3 p. 557 - 560 Steroids, , vol. 71, # 10 p. 911 - 921 Ms-PEG4-Ms CAS#:55400-73-2 Bromo-PEG4-bromide CAS#:57602-02-5 Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 2 p. 636 - 643 Precursor & DownStream Precursor 5 CAS#:4792-15-8 Pentaethylene glycol CAS#:109789-39-1 Pentaethylene G... CAS#:55400-73-2 Ms-PEG4-Ms CAS#:5197-65-9 Chloro-PEG5-chloride DownStream 2 CAS#:212262-08-3 3,6,9,12-tetrao... CAS#:89141-20-8 2-[2-[2-[2-(2-s... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 5.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
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